Yingchun Zhang
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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
ZCCHC4 promotes replication-dependent histone mRNA translation through interaction with the eIF3 complex
Abstract Histone synthesis is tightly coupled with DNA replication to ensure proper chromatin assembly and genome stability. To meet the sharply elevated demand for histones during S phase, eukaryotic cells employ specialized mechanisms to translate replication-dependent (RD) histone mRNAs. These mRNAs possess distinctive features, such as specific UTR structures and the absence of poly(A) tails.
Gut bacterial vesicles from the E. coli Δ aroD mutant extend C. elegans lifespan
Abstract While bacterial membrane-derived vesicles (MDVs) are known for immune functions, this study reveals their anti-aging properties. MDVs from E. coli ΔaroD extend lifespan and alleviate aging phenotypes in Caenorhabditis elegans. We identified Novel27, a miRNA-like sRNA in these MDVs, which increases longevity by 32.8% by directly downregulating the target gene unc-13. These findings reveal a novel MDV-mediated anti-aging mechanism and establish unc-13 as a key regulator of longevity.
Integrated Network Pharmacology and Machine Learning to Reveal the Mechanisms of Schisandrin A Against Triple-Negative Breast Cancer
1 Introduction Malignant tumours represent a significant public health challenge, posing a substantial threat to global health. In 2022, breast cancer emerged as the most prevalent malignancy in terms of both incidence and mortality among females worldwide, with an age-standardized incidence rate of 46.8 per 100,000 individuals and an age-standardized mortality rate of 12.7 per 100,000 individuals [1].
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