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Yingfeng Tu

As seen in: Color Research & Application, Nature, Wiley Online Library, ACS Publications, Flipboard, Royal Society of Chemistry, Cell Press, Chemistry World
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Articles

XunZi, an AI biologist, reveals disease-modifying targets

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By Xinhe Huang, Junhong Qin, Fei Tang, Chenyu Yang, Linhua Xu, Dan Liu, Kang Chen, Chi Zhang, Miaomiao Chen, Yujie Gou, Jiayi Zhang, Yongze Ma, Lin Zhao, Yingfeng Tu, Peng Lei, Yu Xue, Da Jia, Junfen Wei
| Nature Verified
Abstract Hypothesis generation in biomedicine is constrained by human cognitive limitations in synthesizing insights from fragmented biomedical knowledge and multimodal data sources. Here we introduce XunZi, an AI biologist that integrates logical reasoning and multimodal data fusion to autonomously generate de novo therapeutic target hypotheses with testable mechanisms.
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Photochemical nanomotors reverse anxiety- and depressive-related behaviors in rodents via spatiotemporal polarity dynamics tuning - Nature Communications

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By Bin Lin Chen, Miaomiao Ding, Ye Feng, Chao Gao, Haixin Tan, Hao Tian, Daniela A. Wilson, Yecheng Zhou, Yingfeng Tu, Fei Peng, Jinghui Rong
| Nature Verified
Abstract Anxiety and mood disorders, notably major depressive disorder characterized by suppressed neuronal excitability, involve disruption of endogenous molecular polarity homeostasis. Conventional monoamine antidepressants, constrained by delayed therapeutic onset and high risk of drug resistance, neglect and fail to address this pathological feature. Here, we report IC@His-ICG, a near-infrared-responsive photochemical nanomotor that enables polarity switching.
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Chemotactic Zn micromotor for treatment of high blood ammonia-associated hepatic encephalopathy - Nature Communications

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By Daniela A. Wilson, Yingfeng Tu
| Nature Verified
Abstract Hepatic fibrosis involves hepatocyte damage, causing blood ammonia accumulation, which exacerbates liver pathology and crosses the blood-brain barrier, inducing hepatic encephalopathy. It is meaningful to construct a therapeutic platform for targeted ammonia clearance. In this work, a biocompatible water-powered Zn micromotor is constructed as an ammonia chemotaxis platform, which can be actuated by the water splitting reaction and the self-generated Zn2+ gradient.
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