Yinghong Yang

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1. Introduction Coenzyme Q10 (CoQ10) is a vitamin-like, fat-soluble organic compound and it was identified for the first time by Frederick Crane of Wisconsin (USA) in 1957 [1,2]. It comprises a quinone group and a side-chain of 10 units of isoprene (). It can be synthesized by human cells and is ubiquitously present in cell membranes [3,4].

Background: Bladder cancer is one of the most common type of cancers globally, and the majority of cases belong to urothelial bladder carcinoma (UBC) type. Current researches have demonstrated that multiple genomic abnormalities are related to the sensitivity of cisplatin-based chemotherapy in bladder cancer patients. Previous findings have indicated a controversial role of Ubiquitin Carboxy-Terminal Hydrolase L1 (UCHL1) in malignancy, so we aimed to further explore the role of UCHL1 in UBC.