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Articles by Yingping Hou
SCOPE-C reveals long-range enhancer networks emerging as key regulators during human cortical neurogenesis
Keywords 3D genome enhancer network cortical neurogenesis human brain evolution Get full text access Log in, subscribe or purchase for full access. References 1. Geschwind, D.H. ∙ Rakic, P. Cortical Evolution: Judge the Brain by Its Cover Neuron. 2013; 80:633-647 2. Won, H. ∙ Huang, J. ∙ Opland, C.K. ... Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility Nat. Commun. 2019; 10, 2396 3. Rakic, P. ∙ Ayoub, A.E. ∙ Breunig, J.J. ...
Long-Range Enhancer Networks Gradually Emerge as Key Regulators During Human Cortical Neurogenesis
Abstract The chromatin in the human brain cortex shows more enhancer-enhancer contacts than in macaques and mice, yet the organization of these contacts across cellular states and their mechanisms remain unclear. Here, we developed SCOPE-C, a cost-effective technique designed for mapping DNase I Hypersensitive Sites and their spatial interactions, with the potential for scalability to single-cell resolution.
Transcription-coupled structural dynamics of topologically associating domains regulate replication origin efficiency - Genome Biology
Yongzheng Li1,2 na1, Boxin Xue1,3 na1, Mengling Zhang1 na1, Liwei Zhang4, Yingping Hou5, Yizhi Qin1, Haizhen Long4, Qian Peter Su1,6, Yao Wang1, Xiaodong Guan1, Yanyan Jin7, Yuan Cao1, Guohong Li4,8 & Yujie Sun ORCID: orcid.org/0000-0002-9489-48201,9 Genome Biology volume 22, Article number: 206 (2021) Cite this article Abstract Background Metazoan cells only utilize a small subset of the potential DNA replication origins to duplicate the whole genome in each cell cycle.
3D Genome of macaque fetal brain reveals evolutionary innovations during primate corticogenesis
Highlights • Construction of a high-resolution Hi-C map of macaque fetal brain • Cross-species 3D genome analyses uncover human-specific chromatin structures • The subplate lamina shows human-specific regulatory changes during corticogenesis • The human-specific loop regulating EPHA7 affects neuron dendrite development Summary Elucidating the regulatory mechanisms of human brain evolution is essential to understanding human cognition and mental disorders.
Spying on Protein Interactions in Living Cells with Reconstituted Scarlet Light
BiFC (Bimolecular fluorescence complementation) assay and BiFC combining with FRET (Fluorescence resonance energy transfer) technique have become important tools for molecular interaction studies in live cells.
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