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Yingqin Li

As seen in: Nature
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Articles

Multi-omic characterization of nasopharyngeal carcinoma delineates the subtype-specific landscape of response to induction chemotherapy

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By Yingqin Li, Dongxue Wang, Zaoqu Liu, Xianfeng Shao, Yuheng Zhao, Xinxin Zhang, Jiaxi Shen, Xu Liu, YUAN ZHANG, Xiaoyu Liang, Yaoyi Li, Huimin Huang, Linhai Xie, Gaoyuan Wang, Kaixuan Li, Qianying Yang, Linglong Tang, Lei Chen, Yin Zhao, Sha Xu, Ying Sun, Jia-Xing Yue, Na Liu, Aihua Sun, Jun Ma, Fuchu He, Chunxian Ou, Qingmei He, Yelin Liang
| Nature Verified
Abstract Gemcitabine and cisplatin (GP) serve as first-line induction chemotherapy (IC) for nasopharyngeal carcinoma (NPC), yet predictive markers are lacking. Here we performed multi-omics profiling, including proteomics, phosphoproteomics, genomics and transcriptomics, on 240 patients with NPC who were receiving GP-IC or concurrent chemoradiotherapy (CCRT) alone. Through multi-omic integration, we identified three proteomic subtypes with distinct therapeutic vulnerabilities.
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Enzymatically Synthesized Poly(amino-co-ester) Polyplexes for Systemic Delivery of pcDNA-miRNA-214 to Suppress Colorectal Cancer Liver Metastasis

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By Zhe Yang, Wei Wei, Yingqin Li, Huiyan Luo
| Royal Society of Chemistry Verified
Liver metastases from colorectal cancer (CRC) are the major cause of cancer-related deaths in CRC patients. In our previous study, microRNA-214 (miR-214) was identified in CRC patients as a novel regulator of CRC liver metastasis, which could be serve as a therapeutic target to inhibit the CRC proliferation and metastasis. In this study, we aim to develop a new CRC treatment strategy based on miR-214 gene therapy using biodegradable non-viral gene vector.
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Microarray Expression Profiling of Long Non-Coding RNAs Involved in Nasopharyngeal Carcinoma Metastasis

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By Xin Wen, Xinran Tang, Yingqin Li, Xianyue Ren
| MDPI
Increasing evidence has demonstrated a significant role for long non-coding RNAs (lncRNAs) in tumorigenesis. However, their functions in nasopharyngeal carcinoma (NPC) metastasis remain largely unknown. In this study, a model comparing high and low metastatic NPC cell lines (5-8F vs. 6-10B and S18 vs. S26) was constructed to determine the expression profile of lncRNAs using the microarray analysis, and we found 167 lncRNAs and 209 mRNAs were differentially expressed.
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