Yingxiao Zhang
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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
Targeting FoxO1/3a, NF-κB, and mTOR signaling attenuates muscle atrophy in sepsis
Abstract Sepsis frequently leads to skeletal muscle atrophy, but its molecular mechanisms remain unclear. Using a mouse model of cecal ligation and puncture and LPS-treated C2C12 myotubes, we found that sepsis activates autophagy, the ubiquitin-proteasome system (UPS), and calpain pathways, resulting in muscle wasting and functional decline. These changes were linked to upregulated FoxO1/3a and NF-κB signaling and suppressed mTOR activity.
Student Interest Drives Modernization of Climate Science Curriculum: Engaging with Community Partners Outside the Classroom
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Bidirectional effect of uric acid on C2C12 myotubes and its partial mechanism
Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
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