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Yingying Tong

As seen in: Nature, Wiley Online Library, MDPI, Cell Metabolism, Cell Press
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Articles

Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion

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By Dong Guo, Ying Meng, Qingqing Yang, Shudi Luo, Xiaoming Jiang, Yanhua Zheng, Lihui Wu, Suyao Li, Hongfei Jiang, Shan Li, Zheng Wang, Min Li, Qingang Wu, Liwei Xiao, Rongxuan Zhu, Xuxiao He, Yanyan Hu, Hong Zhao, Xianglai Ye, Yingying Tong, Jing Fang, Daqian Xu, Jun Xu, Ying Yuan, Zhimin Lu
| Cell Press Verified
Keywords lactate STING PKM2 LDHA EGFRvIII PD-1 immune evasion Get full text access Log in, subscribe or purchase for full access. References 1. Li, T. ∙ Chen, Z.J. The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer J. Exp. Med. 2018; 215:1287-1299 2. Roers, A. ∙ Hiller, B. ∙ Hornung, V. Recognition of Endogenous Nucleic Acids by the Innate Immune System Immunity. 2016; 44:739-754 3. Sun, L. ∙ Wu, J. ∙ Du, F. ...
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OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth

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By Dong Guo, Qiujing Yu, Yingying Tong, Xu Qian, Ying Meng, Xiaoming Jiang, Lihui Wu, Qingqing Yang, Suyao Li, Qingang Wu, Liwei Xiao, Xuxiao He, Rongxuan Zhu, Guijun Liu, Dou Nie, Shudi Luo, Leina Ma, Ren-an Jin, Zhihua Liu, Xiao Liang, Dong Yan, Zhimin Lu
| Cell Press Verified
Keywords OXCT1 SUCLA2 succinylation succinyl-CoA ketone body ketolysis tumorigenesis Introduction Cancer metabolism is programmed to facilitate the survival and proliferation of cancer cells in the non-native tumor microenvironment.1 A rapidly growing tumor inevitably encounters energy stresses, and ketone bodies can be used as an energy source to fuel cell growth of different types of cancers, such as melanoma, hairy cell leukemia, hepatocellular carcinoma (HCC), prostate cancer, and breast...
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OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth

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By Dong Guo, Qiujing Yu, Yingying Tong, Xu Qian, Ying Meng, Xiaoming Jiang, Lihui Wu, Qingqing Yang, Qingang Wu, Liwei Xiao, Xuxiao He, Rongxuan Zhu, Guijun Liu, Dou Nie, Shudi Luo, Leina Ma, Zhihua Liu, Xiao Liang, Dong Yan, Zhimin Lu, Suyao Li, Ren-an Jin
| Cell Press Verified
Keywords OXCT1 SUCLA2 succinylation succinyl-CoA ketone body ketolysis tumorigenesis Get full text access Log in, subscribe or purchase for full access. References 1. Lyssiotis, C.A. ∙ Cantley, L.C. Acetate fuels the cancer engine Cell. 2014; 159:1492-1494 2. Huang, D. ∙ Li, T. ∙ Wang, L. ... Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress Cell Res. 2016; 26:1112-1130 3. Saraon, P. ∙ Cretu, D. ∙ Musrap, N. ...
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