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Yinwen Zhang on Muck Rack

Yinwen Zhang

As seen in: PLOS, PNAS, BioRxiv, Optica
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Articles

Dynamic evolution of the heterochromatin sensing histone demethylase IBM1

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By Yinwen Zhang, Hosung Jang, Ziliang Luo, Yinxin Dong
| PLOS
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Zhang Y, Jang H, Luo Z, Dong Y, Xu Y, Kantamneni Y, et al. (2024) Dynamic evolution of the heterochromatin sensing histone demethylase IBM1. PLoS Genet 20(7): e1011358.
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Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid.

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By Min Pan, Yinwen Zhang, William Wright, Xueying Liu
| BioRxiv
Abstract Retinoic acid (RA) is a standard-of-care neuroblastoma drug thought to be effective by inducing differentiation. Curiously, RA has little effect on primary human tumors during upfront treatment but can eliminate neuroblastoma cells from the bone marrow during post-chemo consolidation therapy - a discrepancy that has never been explained.
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Dynamic evolution of the heterochromatin sensing histone demethylase IBM1

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By Yinwen Zhang, Robert J Schmitz, Hosung Jang, Ziliang Luo
| BioRxiv
Abstract Heterochromatin constitutes a fundamental aspect of genomes that is crucial for maintaining genome stability. In flowering plants, maintenance of heterochromatin relies on a positive feedback loop involving the histone 3 lysine nine methyltransferase (H3K9), KRYPTONITE (KYP), and the DNA methyltransferase, CHROMOMETHYLASE3 (CMT3). An H3K9 demethylase, INCREASED IN BONSAI METHYLATION 1 (IBM1), has evolved to modulate the activity of KYP-CMT3 within transcribed genes.
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