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Closing Knowledge Gaps on Global Budget of Nitrogen Oxides (NO x ) by Quantifying Indirect Emissions From Anthropogenic Nitrogen
1 Introduction Short-lived reactive nitrogen (N) trace gases, particularly nitrogen oxides (NOx) including nitric oxide (NO) and nitrogen dioxide (NO2), are key precursors of fine particulate matter (PM2.5) and tropospheric ozone and therefore play critical roles in affecting air pollution, atmospheric chemistry, human health, and ecosystem functioning (e.g., Gong et al. 2024; IPCC 2021; Moënne-Loccoz and Fee 2010; Medinets et al. 2015; Wang et al. 2022).
Integrated metabolomics and network pharmacology reveals that icariin antagonizes malignant phenotypes in triple-negative breast cancer via AKT1/SRC/NFKB1-mediated PI3K‒AKT pathway inhibition
Abstract Breast cancer is a highly prevalent cancer among women worldwide. The triple-negative breast cancer (TNBC) subtype has a particularly poor prognosis, is characterized by high invasiveness and low survival rates, and is currently a major challenge in the clinical treatment of breast cancer. This study aims to analyze the drug metabolism pathways of TNBC and provide a preclinical foundation for potential therapeutic strategies.
Foliar metal micronutrients reshape rhizosphere soil multifunctionality by filtering microbial life-history strategies
Abstract Foliar application of metal micronutrients is increasingly adopted in intensive cultivation systems, yet its potential ecological risks to rhizosphere functions remain poorly understood. Here, using the medicinal plant Panax notoginseng as a model, we conducted a gradient foliar amendment experiment with iron (Fe), zinc (Zn), and copper (Cu) to evaluate how aboveground metal inputs regulate rhizosphere soil multifunctionality (MF) through microbial life-history strategies.
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