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Keywords aging senescence biomarker stem cell intervention rejuvenation gene editing FOXO3 brain reproductive system Introduction Aging, an unavoidable trajectory, precipitates tissue and physiological deterioration, leading to conditions such as neurodegenerative diseases, reduced fertility, and cardiovascular problems.1,2,3,4,5,6,7,8,9,10,11 Emerging research implicates the decline of stem cell populations and a diminishing regenerative potential as pivotal to the aging...
Lumbar disc (LD) herniation and aging are prevalent conditions that can result in substantial morbidity. This study aimed to clarify the mechanisms connecting the LD aging and herniation, particularly focusing on cellular senescence and molecular alterations in the nucleus pulposus (NP). We performed a detailed analysis of NP samples from a diverse cohort, including individuals of varying ages and those with diagnosed LD herniation.
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