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Jiayin Yang on Muck Rack

Jiayin Yang

As seen in: Nature, Wiley Online Library, MDPI, BMC Cancer, Cell Metabolism, Cell Press, JoVE- Journal of Visualized Experiments
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Articles

Btg2 inhibits Fmo1 UFMylation thus exacerbating ferroptosis and apoptosis in hepatic ischemia-reperfusion injury

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By Dadi Peng, Yihua Wang, Dengliang Lei, Kezhen Zong, Shanshan Li, Yunhai Luo, Qiuying Li, Liqing Jiang, Weifeng Huang, Huarong Yu, Jiayin Yang, Zuotian Huang, Zhongjun Wu, Yulin Ou
| Nature Verified
Abstract Hepatic ischemia‒reperfusion injury (HIRI) represents a frequently occurring pathological condition during liver surgery, yet the mechanisms governing HIRI remain inadequately comprehended. Here, we investigate the role of B-cell translocation gene 2 (Btg2) in HIRI. Btg2 is upregulated following HIRI. A 70% HIRI model using hepatocyte-specific Btg2 transgenic and systemic Btg2 knockout mice reveals that Btg2 deteriorates hepatic inflammation and apoptosis.
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Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates

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By Lixiao Liu, Zikai Zheng, Wanbang You, Peng Yang, Yifan Wen Verified, Yicheng Qiao, Shuai Ma, Shuo Zhang, Gang Xu, Chencan Ma, Ao Tian, Mengmeng Jiang, Tongtong Zhang, Lingling Geng, Jingyi Li, Xiaoyan Sun, Feibo Wang, Muzhao Xiong, Yuanhan Yang, Xiaoyong Lu, Xiaoyu Jiang, Xueda Dong, Zhiyi Zhang, Ying Huang, Baohu Zhang, Qin Qiao, Shuhui Sun, Yanling Fan, Yusheng Cai, Kaowen Yan, Yiyuan Zhang, Ying Jing, Yaobin Jing, Qiaoran Wang, Jinghui Lei, Ansheng Tan, Zichu Han, Pradeep Reddy, Amin Haghani, Concepcion Rodriguez Esteban, Feng Zhang, Zhili Liu, Ning Liu, Si Qi Wang, Steve Horvath, Jiayin Yang, Weiqi Zhang, Jing Qu, Guang-Hui Liu
| Cell Metabolism Verified
ArticleVolume 38, Issue 4p673-693.e17 Affiliations & Notes 1China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China 2State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China 3University of Chinese Academy of Sciences, Beijing 100049, China 4State Key Laboratory of Cognitive Science and Mental Health, Institute of Biophysics, Chinese Academy of...
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Arginase 1 promotes hepatic lipogenesis by regulating ERK2/PPARγ signaling in a non-canonical manner - Nature Communications

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By Mingyang Shao, Xiaoyue Cao, Yuwei Chen, Ziqi Zhu, Yuke Shu, Qing Tao, Qing Xu, Tingting Ma, Zhenru Wu, Menglin Chen, Yongjie Zhou, Rong Yao, Junhua Gong, Jiayin Yang, Yujun Shi
| Nature Verified
Abstract Obesity and related metabolic disorders, including metabolic dysfunction-associated steatohepatitis (MASLD), have reached epidemic proportions worldwide. We unveil a previously unknown moonlighting role for arginase 1 (Arg1) in facilitating hepatic lipogenesis. Male mice lacking hepatic Arg1 exhibit diminished lipid accumulation in both liver and adipocytes, an effect mirrored in genetically- or diet-induced obesity models following Arg1 inhibitor treatment.
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