Zhanyan Fu

Abstract Belief updating is thought to be impaired in schizophrenia, leading to delusions. The neural substrates underlying belief updating are unknown, in part due to a lack of appropriate animal models and behavior readouts. We generated mice bearing a schizophrenia-associated point mutation in Grin2a (Grin2aY700X+/−) and developed a computationally trackable foraging task to assess belief-driven decision strategies in mice.

ResourceVolume 43, Issue 12115037Open access 1Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA 2Yang Tan Collective and McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Publication History: Received June 8, 2023; Revised September 27, 2024; Accepted November 14, 2024; Published online December 3, 2024 DOI:...

Introduction Fragile X syndrome (FXS) is one of the most common heritable neurodevelopmental disorders, which is characterized by intellectual disability, epilepsy, and behavioral symptoms such as anxiety and hyperactivity (Bhakar et al., 2012; Nelson et al., 2013). The etiology stems from a trinucleotide expansion mutation in the 5′ untranslated region of the FMR1 gene, thus leading to the loss of fragile X messenger ribonucleoprotein (FMRP) (Verkerk et al., 1991).