Zhen Cui
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Articles by Zhen Cui
Structural mechanisms for ATP-mediated inhibition of human NLRP6 inflammasome
Abstract Inflammasomes ignite innate immune defense in response to infectious pathogens and noninfectious dangers, primarily through sensors composed of nucleotide-binding domain (NBD), leucine-rich repeat (LRR)-containing (NLR) family proteins. NLRP6 is an inflammasome sensor that plays critical roles in regulating intestinal inflammation, and its overactivation is linked to autoinflammatory diseases such as inflammatory bowel disease.
MUC13 promotes cisplatin resistance in intrahepatic cholangiocarcinoma through regulation by histone H3K18 lactylation
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Abstract Cisplatin resistance remains a major clinical challenge in intrahepatic cholangiocarcinoma (iCCA); however, its underlying mechanisms are poorly understood. Building on our previous study that identified Mucin 13 (MUC13) as an oncogenic driver, we aimed to investigate its contribution to cisplatin resistance.
By Zhijie Yin, Qingfu Lang, Jia Sun, Yinfan Wang, Chen Jia, Boxin Chen, Zhen Cui, Ze Wang, Wenjun Chen, Zejun Luo, Ming Yang Verified, Tiemin Pei
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Nature
Verified
Histone lactylation-driven IGF2BP3 promotes intrahepatic cholangiocarcinoma progression via SPP1/CD44-dependent macrophage polarization
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Abstract The tumor microenvironment is a critical regulator of cancer progression. Histone lactylation, a novel post-translational modification, has emerged as a key player in various tumors and is closely linked to macrophage polarization within the immune tumor microenvironment. Here, we delineated the signaling axis through which histone lactylation, specifically H3K18la, orchestrates crosstalk between intrahepatic cholangiocarcinoma cells and the tumor microenvironment (TME).
By Zhijie Yin, Jia Sun, Yinfan Wang, Boxin Chen, Chen Jia, Zhen Cui, Ze Wang, Wenjun Chen, Zejun Luo, Ming Yang Verified, Ming Zhao, Peng Xiao, Qingfu Lang, Tiemin Pei
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Nature
Verified
Automatic pain assessment from facial action units in ICU patients via various machine learning models
Abstract Pain represents a critical vital sign monitored in intensive care unit (ICU) patients. The facial action coding system (FACS) defines facial action units (AUs) and provides a structured framework for pain recognition. Currently, the most broadly used pain assessment method is the pain intensity scale developed by Prkachin and Solomon (PSPI), which relies on predefined AUs to quantify facial expressions.
Effects of ground motion spectral characteristics on RC frame fragility considering liquefaction
Abstract Seismic liquefaction represents a persistent and complex engineering challenge in soil dynamics. Post-earthquake damage investigations have shown that damage to buildings caused by site liquefaction constitutes a significant proportion of all seismic damage.
Multivariate Analysis of Shock Risk and Model Development and Validation in Elderly Patients Following Hip Fracture Surgery in the Intensive Care Unit (ICU): A Retrospective Cohort Study
Xue Wang, Zhen Cui, Mengqi Tong, Miaomiao Yu, Ying Bai Department of Critical Care Medicine, Beijing Jishuitan Hospital Affiliated to Capital Medical University, Beijing, People’s Republic of China Correspondence: Ying Bai, Department of Critical Care Medicine, Beijing Jishuitan Hospital Affiliated to Capital Medical University, Beijing, People’s Republic of China, Email [email protected] Purpose: This study aimed to identify risk factors for postoperative shock and develop and validate a...
Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron
Main text (Cell 185, 860–871.e1–e4; March 3, 2022) In the originally published version of this paper, the authors noted errors in several parts of the manuscript.
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Editor’s summary Somewhat lacking in good looks, the naked mole rat gets attention because it is very long lived and highly resistant to cancer. Chen et al. revealed a molecular mechanism that contributes to successful aging in these rodents: a change in the enzyme cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS), which is known to sense cytosolic DNA and initiate immune defense responses (see the Perspective by Martinez et al.).
DNA Nanotechnology‐Engineered Supramolecular Hydrogel Biosensor for Cancer Diagnosis via Extracellular Vesicles
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm70537-sup-0001-SuppMat.pdf4.7 MB Supporting Information References 1, , , Nat. Rev. Clin. Oncol. 2021, 18, 297. 2a) , , , , , , , , Mol. Cancer 2022, 21, 56; b) , , , , , , , J. Am. Chem. Soc. 2020, 142, 4996; c) , , , , , , , , , , , , , , , , , Nat. Commun. 2021, 12, 2536. 3a) , , , , Nat. Rev. Mol. Cell Biol. 2023, 24, 454; b) , , , , , , , , , , Acta Pharm. Sin. B.
Iron-Catalyzed [3 + 2] Annulation of O-Acyl Oximes with 2-Hydroxy-1-Naphthoates for the Synthesis of Benzo[g]indoles
Organic Letters Cite this: Org. Lett. 2025, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
The Ecological Risks of Heavy Metals in the Estuarine Wetland Ecosystem and Their Impacts on Human Health: A Case from Yellow River Delta National Nature Reserve, China
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Mechanical Properties of Marble Under Triaxial and Cyclic Loading Based on Discrete Elements
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Self-powered photodetector of GaN/Sc2CCl2 heterojunction with high carrier mobility and polarization sensitivity
Self-powered photodetector of GaN/Sc2CCl2 heterojunction with high carrier mobility and polarization sensitivity This study is based on first-principles calculations to investigate the GaN/Sc2CCl2 heterojunction, and its electrical properties, optical properties, and photogalvanic effect under linearly polarized light are calculated.
Mechanical Response Study of a Cross-Fault Water Conveyance Tunnel under the Combined Action of Faulting Dislocation and Seismic Loading
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Energy absorption properties of origami‐based re‐entrant honeycomb sandwich structures with CFRP subjected to low‐velocity impact
This paper investigates a honeycomb sandwich structure that draws inspiration from the craft of origami. A specific folding pattern was applied to the honeycomb to create the origami-based re-entrant honeycomb (ORH), aimed at improving the energy absorption properties of the sandwich structure. The study on the energy absorption properties of structures under low-velocity impact (LVI) utilized both experimental and numerical approaches.
Highly Sensitive and Selective Defect WS2 Chemical Sensor for Detecting HCHO Toxic Gases
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
LightRoseTTA: High-efficient and Accurate Protein Structure Prediction Using an Ultra-Lightweight Deep Graph Model
Abstract Accurately predicting protein structure, from amino acid sequences to three-dimensional structures, is of great significance in biological research. To tackle this issue, a representative deep big model, RoseTTAFold, has been proposed with promising success. Here, we report an ultra-lightweight deep graph network, named LightRoseTTA, to achieve accurate and high-efficient prediction for proteins.
Cobalt‐Catalyzed Annulation of o‐Phenylenediamines and Internal Alkynes: Efficient Synthesis of Quinoxaline Derivatives
A cobalt-catalyzed annulation of o-phenylenediamines and internal alkynes for the synthesis of quinoxalines is developed. This method provides a variety of quinoxalines in good to high yields under a simple and mild reaction conditions with molecular O as a terminal oxidant. Preliminary mechanistic studies show that a novel reaction mechanism is involved in the current reaction, which is different from the previous reported dicarbonyl compound mechanism via the oxidation of the alkyne.
Cobalt‐Catalyzed Annulation of o‐Phenylenediamines and Internal Alkynes: Efficient Synthesis of Quinoxaline Derivatives
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Study of Mechanical Response of Tunnels Crossing Active Faults in Different Burial Depths
4. Analysis of Mechanical Response Characteristics of Cross-Fault Tunnels at Different Burial Depths To investigate the mechanical response characteristics of tunnels crossing active faults at varying burial depths, we conducted a comparative analysis of displacement patterns, stress, and strain responses for tunnel depths ranging from 100 m to 1200 m. It allowed us to summarize the damage patterns of tunnels under the influence of fault displacement at different burial depths.
g-ZnO/Si9C15: a S-scheme heterojunction with high carrier mobility for photo-electro catalysis of water splitting
g-ZnO/Si9C15: a S-scheme heterojunction with high carrier mobility for photo-electro catalysis of water splitting† The g-ZnO/Si9C15 heterojunction is designed, and its stability, electronic properties and photo-electro catalytic properties, and the impact of biaxial strain on the electronic and photocatalytic properties are investigated. The g-ZnO/Si9C15 heterojunction has a staggered (type-II) band structure (band gap is 1.770 eV), following the S-scheme mechanism.
Improving the Pulse-Limited Footprint Resolution of GNSS-R Based on the Novel Joint Bandwidth Method
1. Introduction In recent years, GNSS signals have been found to be applicable to various environmental remote sensing technologies. For example, Martin-Neira (1993), Katzberg et al. (1996), and Garrison et al. (1997, 1998) found that the multipath effect of GNSS signals reflected from the sea surface can serve as a new tool for ocean remote sensing [1,2,3,4].
DeepTPpred: A Deep Learning Approach with Matrix Factorization for Predicting Therapeutic Peptides by Integrating Length Information
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Adsorption of Metal Atoms on SiC Monolayer
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Lei Jiang *, Yanbo Dong and Zhen Cui * School of Automation and Information Engineering, Xi’an University of Technology, Xi’an 710048, China * Authors to whom correspondence should be addressed.
Effects of Different Trace Elements on Ecophysiological Characteristics of Ligustrum obtusifolium Saplings
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Compressive Strength Prediction of Rice Husk Ash Concrete Using a Hybrid Artificial Neural Network Model
5. Results and Discussion After training the proposed models, the predictive performance of each model was properly evaluated. Figure 7 shows the prediction curves of all models for estimating the compressive strength of RHA concrete in the training phase. The difference between the prediction curve of the empirical model and the training curve was the greatest among all models.
Low-Velocity Impact Resistance of 3D Re-Entrant Honeycomb Sandwich Structures with CFRP Face Sheets
Abstract : Lightweight sandwich structures have been receiving significant attention. By studying and imitating the structure of biomaterials, its application in the design of sandwich structures has also been found to be feasible. With inspiration from the arrangement of fish scales, a 3D re-entrant honeycomb was designed. In addition, a honeycomb stacking method is proposed.
DLoopCaller: A deep learning approach for predicting genome-wide chromatin loops by integrating accessible chromatin landscapes
The generation of training samples The data inputs of DLoopCaller mainly include three parts: the original Hi-C matrix, some verified positive interactions involving targeted regions or proteins of interest by biologically enriched experiments such as ChIA-PET/HiChIP and Capture Hi-C, and the corresponding accessible chromatin landscapes, which were then used to generate training samples for training model.
Affective video recommender systems: A survey
Introduction Emotion or affection is a mental state which is unconscious and spontaneously arises accompanied by physiological and psychological status changes in human organs and tissues, e.g., heart rate, facial expression, brain, etc. (Shu et al., 2018b). Emotions are universal and have proved to be a highly multidisciplinary research field, from psychology, sociology, and neuroscience to computer science (Baveye et al., 2018).
Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron
Highlights Omicron spike stably maintains an active conformation for receptor recognition Improved stability of Omicron enhances attachment but compromises viral fusion Mutations perturb the conformation of antigenic sites recognized by most antibodies Structurally restrained regions of RBM can be targets for COVID-19 countermeasures SUMMARY The SARS-CoV-2 Omicron with increased fitness is spreading rapidly worldwide.
Investigating the Deformation and Failure Mechanism of a Submarine Tunnel with Flexible Joints Subjected to Strike-Slip Faults
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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