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Articles by Zhou He
Efficient and precise large-scale genomic duplication using amplification editing
Abstract Genomic duplication is a common type of structural variation that has important roles in gene dosage regulation and contributes to the development of various human diseases including cancer and inherited disorders. However, current genome-editing technologies are limited in their ability to introduce precise and efficient DNA duplications.
COPD/OSA phenotypes and inpatient outcome patterns among primary total hip arthroplasty hospitalizations: a national inpatient sample study, 2016–2022
Abstract Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) are common among patients undergoing total hip arthroplasty (THA), but whether COPD-only, OSA-only, and coexisting COPD + OSA define distinct inpatient risk phenotypes remains unclear. This retrospective cohort study used the 2016–2022 National Inpatient Sample to identify adult primary THA hospitalizations. Hospitalizations were categorized as no COPD/no OSA, COPD only, OSA only, or COPD + OSA overlap.
Quadruple pegRNA enables programmable and efficient large genomic insertion
Abstract Precise, site-specific insertion of large gene sequences holds great promise for the treatment of diverse genetic disorders. Although prime editing using paired guide RNAs (pegRNAs) can mediate targeted integration, insertion efficiency drops sharply for payloads exceeding 300 base pairs1,2,3. Here we present a rationally designed quadruple pegRNA strategy (QuadPE) for efficient and programmable insertion of large DNA fragments.
Top Natural Sweeteners Manufacturers Continue to Gain Ground as the Global Market Shifts Toward Healthier Ingredients
CHENGDU CITY, CHINA, March 9, 2026 /EINPresswire.com/ -- The global food and beverage industry is undergoing a significant transformation. Consumers in markets across North America, Europe, and Asia-Pacific are actively reducing their intake of refined sugar, and this shift has created strong demand for natural sweeteners. As a result, the manufacturers behind these ingredients are playing an increasingly important role in the supply chain.
Group 13 Lewis acid-mediated formation of 5-oxazolone derivatives from tert-butyl isocyanoacetate†
Group 13 Lewis acid-mediated formation of 5-oxazolone derivatives from tert-butyl isocyanoacetate† Tert-butyl isocyanoacetate 1 reacted with B(C₆F₅)₃ to give a Lewis acid-base adduct 2. GaCl₃ and GaI₃ promoted cyclization affording the N-bound Lewis acid adducts of the cyclized product 5-oxazolone derivatives 3 and 4 resulting from isocyano insertion into the ester C–O bond, with loss of isobutylene.
A Highly Stabilized Current Source Topology with Slope Compensation for a High-Power Microwave Guiding Coil
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Enhanced Unmanned Surface Vehicle Path Planning Based on the Pair Barracuda Swarm Optimization Algorithm: Implementation and Performance in Thousand Island Lake
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Advanced Modulation Formats for 400 Gbps Optical Networks and AI-Based Format Recognition
1. Introduction The pervasive intelligence of future 6G networks will enable wireless networks to accurately sense the environment, providing massive and reliable data for real-time decision-making by network artificial intelligence. This organic empowerment of communication and sensing will be one of the core functionalities of 6G technology [1].
A Novel Snow Leopard Optimization for High-Dimensional Feature Selection Problems
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Enhanced Monte‐Carlo tree search for dynamic flexible job shop scheduling with transportation time constraints
With the increasing uncertainty and complexity of industrial production, dynamic events are inevitably happened during the production process. This paper deals with the transportation time constrained dynamic flexible job shop scheduling problem with machine breakdown, new jobs arrival, jobs cancellation, and processing time change of operations. Considering the actual production situation, a makespan rescheduling model based on transportation time is established.
Amplification editing enables efficient and precise duplication of DNA from short sequence to megabase and chromosomal scale
Anzalone A.V. Koblan L.W. Liu D.R. Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors. Nat. Biotechnol. 2020; 38: 824-844 Hsu P.D. Lander E.S. Zhang F. Development and applications of CRISPR-Cas9 for genome engineering. Cell. 2014; 157: 1262-1278 Doudna J.A. Charpentier E. Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science. 2014; 3461258096 Base editing: precision chemistry on the genome and transcriptome of living cells. Nat. Rev. Genet.
Performance Evaluation and Influencing Factors of Scientific Communication in Research Institutions
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Data-Driven Algorithms for Two-Location Inventory Systems
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Blockchain-Embedded Strategic Options for Satellite Operators: Sell, SataaS, or Dual?
1. Introduction 1.1. Importance of the Topic Satellite-as-a-service (SataaS) presents a novel development within the satellite industry, departing from the traditional framework of satellite ownership and operation. This emerging paradigm entails subscribing to satellite services as needed, capitalizing on contemporary satellite technologies like miniaturization, constellation deployments, and cloud-based infrastructure. The mechanism of SataaS is illustrated in Figure 1.
Figure 2. Flow chart of interactive procedures.
Source publication The impact of human resource management (HRM) on corporate growth is a crucial research topic, especially for growth-oriented firms. This paper aims to study how different payment policies (such as recruitment and dismissal strategies and payment plans) affect the human resource market system. Based on the HRM characteristics of growth-oriented fir... Context 1 ...
List of parameters.
Context 1 ... variables may change under the influence of the agents' behaviors. Table 1 presents the parameter settings of the simulation and experiment. "XV, unchanged" means that the agent attribute, once determined, will not be changed by other factors. ... Context 2 ... 10 samples are obtained for each experiment, the mean value is taken as the output. The specific variables and attributes are shown in Table 1 above. ...
Experimental results.
Context 1 ... output data of the model are shown in Table 3. Because the orthogonal table has six columns and the experiment has only four influencing factors, the table has two blank columns (also known as error columns) for the estimation of errors. ...
Jian Yang's research works
What is this page? This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile. It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible.
The Effect of Blockchain Technology on Supply Chain Collaboration: A Case Study of Lenovo
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
The Impacts of Payment Policy on Performance of Human Resource Market System: Agent-Based Modeling and Simulation of Growth-Oriented Firms
The impact of human resource management (HRM) on corporate growth is a crucial research topic, especially for growth-oriented firms. This paper aims to study how different payment policies (such as recruitment and dismissal strategies and payment plans) affect the human resource market system. Based on the HRM characteristics of growth-oriented firms, we develop an agent-based model to simulate the decision-making and interaction behaviors of firms and workers.
Congestion Avoidance in Intelligent Transport Networks Based on WSN-IoT through Controlling Data Rate of Zigbee Protocol by Learning Automata
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by 1,2,*, 1,2,*, 1,2 and 1,2 1 State Key Laboratory of Particle Detection and Electronics, University of Science and Technology of China, Hefei 230026, China 2 Department of Modern Physics, University of Science and Technology of China, Hefei 230026, China * Authors to whom correspondence should be addressed.
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