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Zongshi Lu on Muck Rack

Zongshi Lu

As seen in: Cell Press, Cell Reports
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Articles

Reducing NADPH Synthesis Counteracts Diabetic Nephropathy through Restoration of AMPK Activity in Type 1 Diabetic Rats

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By Xiao Wei, Metabolic Diseases, Zongshi Lu, Hexuan Zhang
| Cell Reports Verified
Highlights • RYGB surgery significantly improves diabetic nephropathy in type 1 diabetes • RYGB ameliorates mitochondrial dysfunction in podocytes by activating AMPK • RYGB surgery restores AMPK activity by reducing NAPDH synthesis • Elevated NAPDH level competes with AMP binding on AMPK in diabetic rats Summary Diabetic nephropathy (DN) is a major complication of diabetes mellitus and a primary cause of end-stage renal failure.
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Deficiency of PKD2L1 (TRPP3) Exacerbates Pathological Cardiac Hypertrophy by Augmenting NCX1-Mediated Mitochondrial Calcium Overload

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By Yuanting Cui, Xing Wei, Peng Gao, Zongshi Lu
| Cell Press Verified
High salt intake is one independent risk factor for cardiac hypertrophy. Polycystic kidney disease 2-like 1 (PKD2L1, also called TRPP3) acts as a sour sensor in taste cells, and its possible role in the cardiovascular system is unknown. Here, we report that knockout of PKD2L1 exacerbated high-salt diet (HSD)-induced cardiac hypertrophy and fibrosis, accompanied by cardiac dysfunction and reduced cardiac mitochondrial oxidative phosphorylation and enzyme activity.
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