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Articles by Aaron Held
Activation of polo-like kinase 1 correlates with selective motor neuron vulnerability in familial ALS
Mutations in the Fused in Sarcoma (FUS) gene cause familial amyotrophic lateral sclerosis (ALS), characterized by selective degeneration of spinal motor neurons (sMNs) with relative sparing of cortical neurons (CNs). The mechanisms underlying this cell-type vulnerability remain unclear. Here, we compare CNs and sMNs derived from FUS-ALS models to assess differential responses to FUS mutations.
High Energy Physics - Phenomenology
[Submitted on 24 Jul 2025 ( v1 ), last revised 6 Oct 2026 (this version, v2)] Title:Quark and lepton mixing in the asymptotically safe Standard Model View a PDF of the paper titled Quark and lepton mixing in the asymptotically safe Standard Model, by Astrid Eichhorn and 2 other authors View PDF HTML (experimental) Abstract:The quark mixing (CKM) matrix is near-diagonal, whereas the lepton mixing (PMNS) matrix is not.
STEADY-STATE REGULATION OF COPII-DEPENDENT SECRETORY CARGO SORTING BY INOSITOL TRISPHOSPHATE RECEPTORS, CALCIUM, AND PENTA EF HAND PROTEINS
ABSTRACT Recently, we demonstrated that agonist-stimulated Ca2+ signaling involving IP3 receptors modulates ER export rates through activation of the penta-EF Hand (PEF) proteins apoptosis-linked gene-2 (ALG-2) and peflin. It is unknown, however, whether IP3Rs and PEF proteins regulate ER export rates at steady state. Here we tested this idea in normal rat kidney (NRK) epithelial cells by manipulation of IP3R isoform expression.
Nonlinear evolution of quadratic gravity in $3+1$ dimensions
We present a numerically stable system of (3+1) evolution equations for the nonlinear gravitational dynamics of quadratic-curvature corrections to General Relativity (quadratic gravity). We also report on the numerical implementation of these evolution equations. We recover a well-known linear instability and gather evidence that—aside from said instability—quadratic gravity exhibits a physically stable Ricci-flat subsector.
Steady-State Regulation of COPII-Dependent Secretory Cargo Sorting by Inositol Trisphosphate Receptors, Calcium, and Penta EF Hand Proteins
Abstract Recently, we demonstrated that agonist-stimulated Ca2+ signaling involving IP3 receptors modulates ER export rates through activation of the penta-EF Hand (PEF) proteins apoptosis-linked gene-2 (ALG-2) and peflin. It is unknown, however, whether IP3Rs and PEF proteins regulate ER export rates at steady state. Here we tested this idea in normal rat kidney (NRK) epithelial cells by manipulation of IP3R isoform expression.
iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons
Highlights • fALS iPSC LMNs capture one-third of gene expression changes in postmortem sALS LMNs • iPSC LMNs, but not other neurons, captured postmortem LMN gene expression changes • Dysregulated genes in fALS iPSC-LMNs include TDP-43 splicing targets • RNA clearance may be disrupted in postmortem LMNs but intact in iPSC LMNs Summary Motor neuron degeneration, the defining feature of amyotrophic lateral sclerosis (ALS), is a primary example of cell-type specificity in neurodegenerative diseases.
Instability of spherically symmetric black holes in quadratic gravity
Abstract We investigate the linear stability of the two known branches of spherically symmetric black holes in quadratic gravity. We extend previous work on the long-wavelength (Gregory-Laflamme) instability of the Schwarzschild branch to a corresponding long-wavelength instability in the non-Schwarzschild branch. In both cases, the instability sets in below a critical horizon radius at which the two black-hole branches intersect.
A Cultured Sensorimotor Organoid Model Forms Human Neuromuscular Junctions
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Circuit Dysfunction in SOD1-ALS Model First Detected in Sensory Feedback Prior to Motor Neuron Degeneration Is Alleviated by BMP Signaling
Featured ArticleResearch Articles, Neurobiology of Disease Aaron Held, Paxton Major, Asli Sahin, Robert A. Reenan, Diane Lipscombe and Kristi A. Wharton Journal of Neuroscience 20 March 2019, 39 (12) 2347-2364; DOI: https://doi.org/10.1523/JNEUROSCI.1771-18.2019 Abstract Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease for which the origin and underlying cellular defects are not fully understood.
Mass Difference for Charged Quarks from Asymptotically Safe Quantum Gravity
Abstract We propose a scenario to retrodict the top and bottom mass and the Abelian gauge coupling from first principles in a microscopic model including quantum gravity. In our approximation, antiscreening quantum-gravity fluctuations induce an asymptotically safe fixed point for the Abelian hypercharge leading to a uniquely fixed infrared value that is observationally viable for a particular choice of microscopic gravitational parameters.
Penta-EF-Hand Protein Peflin Is a Negative Regulator of ER-To-Golgi Transport
Luminal calcium regulates vesicle transport early in the secretory pathway. In ER-to-Golgi transport, depletion of luminal calcium leads to significantly reduced transport and a buildup of budding and newly budded COPII vesicles and vesicle proteins. Effects of luminal calcium on transport may be mediated by cytoplasmic calcium sensors near ER exits sites (ERES).
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