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1Division of Pulmonary Biology, Perinatal Institute, Cincinnati Children’s Hospital Medical Center (CCHMC), Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA 2Center for Stem Cell and Organoid Medicine (CuSTOM), CCHMC, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA 3Division of Developmental Biology, CCHMC, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH...
Keywords esophageal atresia tracheoesophageal fistula EA/TEF foregut morphogenesis Rab11a trachea esophagus Introduction Esophageal atresia (EA) and tracheoesophageal fistulas (TEFs), which affect approximately 1 in 3,000 newborns, are life-threatening congenital anomalies that arise when the embryonic foregut does not separate correctly into distinct trachea and esophageal tubes.1,2,3 This results in esophageal discontinuity (EA) and/or a pathological connection between the trachea and...
One reason why our livers excel at clearing waste from our blood system is that the organ functions according to three key “zones” that perform specific major tasks. So, if scientists hope to create self-growing patches of liver organoid tissue that could help repair damaged organs, it’s important that the lab-grown tissue faithfully reproduce such zones.
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