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Andre Baruchel on Muck Rack

Andre Baruchel

As seen in: Nature, Wiley Online Library, ScienceDirect, The Lancet, European Journal of Cancer
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Articles

Genomic fusion breakpoints for DNA-based measurable residual disease monitoring in pediatric acute lymphoblastic leukemia

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By Chloé Arfeuille, Marion Strullu, Andre Baruchel, Hélène Cavé, Aurélie Caye-Eude, Arno H. Houtman
| Nature Verified
Abstract Measurable residual disease (MRD) is a key prognostic factor in pediatric acute lymphoblastic leukemia (ALL), but current gold-standard methods based on immunoglobulin/T-cell receptor (IG/TCR) rearrangements are complex and not informative in a subset of patients. Genomic breakpoints of oncogenic fusions (GFBs) are stable, biologically grounded markers that may overcome these limitations and improve MRD assessment.
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Characteristics and outcome determinants in children, adolescents and young adults who failed tisagenlecleucel for B-cell acute lymphoblastic leukemia | Leukemia

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By Nicolas Lecornec, Florence Rabian, Marie-Emilie Dourthe, Florian Chevillon, Karima Yakouben, Delphine Chaillou, Sophie Caillat-Zucman, Alexis Cuffel, Emmanuelle Lesprit, Anne Arnould, Jérôme Naudin, Julie Roupret-Serzec, Nathalie Parquet, Anne Brignier, Valérie Guérin-El Khourouj, Elodie Lainey, Aurélie Caye-Eude, Chloé Arfeuille, Emmanuelle Clappier, Rathana Kim, Stephanie M. Mathis, Marie-Laure Chaix, Elie Azoulay, Jean-Hugues Dalle, Isabelle Madelaine, Jérôme Larghero, Andre Baruchel, Nicolas Boissel
| Nature Verified
Abstract Tisagenlecleucel (tisa-cel), an autologous anti-CD19 CAR T-cell therapy, has significantly improved outcomes in pediatric, adolescents and young adults with relapsed/refractory B-cell precursor acute lymphoblastic leukemia (R/R BCP-ALL). However, 30–50% experience early failure or relapse. We retrospectively analyzed 52 cases of early failures (n = 13) or relapses (n = 39), evaluating post-tisa-cel outcomes and prognostic factors.
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Towards methylation-based redefinition of TAL1 positive T-cell acute lymphoblastic leukaemia (T-ALL) - Leukemia

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By Charlotte Smith, Guillaume Andrieu, Agata Cieslak, Christoph Plass, Mehdi Latiri, Andre Baruchel, Elizabeth MacIntyre, Arnaud Petit, Nicolas Boissel, Vahid Asnafi
| Nature Verified
Abstract TAL1 is one of the most frequently dysregulated oncogenes in T-cell Acute Lymphoblastic Leukaemia (T-ALL). However, the precise frequency and prognostic impact associated with its dysregulation remains unclear and is confounded by TAL1’s diverse dysregulation mechanisms.
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