Andrew Mason on Muck Rack

Andrew Mason

As seen in: Nature, Wiley, MDPI, Science Magazine, Daily Report (Georgia), Physical Review B, Times Union (Albany), JD Supra, The Journal of Clinical Investigation, Church Leaders and
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Articles

JAK2V617F reprograms Hypoxia Inducible Factor-1 to induce a non-canonical hypoxia regulon in myeloproliferative neoplasms - Leukemia

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By David Kealy, Ruth Ellerington, Suraj Bansal, Aparna Sinha, Jacob Pope, Bianca Ferreira, Adele Fielding, Bethan Psaila, Andrew Holding, Andrew Mason, Vikas Gupta, Nicole-Mae Blacknell, Jenny Chatzigerou
| Nature
Abstract Hypoxia-inducible factors (HIFs) are master transcriptional regulators, central to cellular survival in hypoxia and frequently activated within malignancy. Whilst malignant context directs the role of HIFs within oncogenesis, these mechanisms are not well characterised. Applying the JAK2V617F myeloproliferative neoplasms (MPNs) oncogene-driver model, in which HIF-1α is stabilised in normoxia (20% O2), we sought to determine whether the modality of HIF-1 activation directs its function.
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Virus-induced APOBEC3 transmutagenesis in bladder cancer initiation

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By Sally James, Andrew Mason, Richard Gawne, George H. Hatton
| Science Magazine
Abstract Carcinogenesis in human urothelium is driven by a high burden of mutations caused by the antiviral “APOBEC3” (apolipoprotein B mRNA editing enzyme, catalytic subunit–like 3) cytosine deaminase enzymes; however, there is no established viral etiology. BK polyomavirus (BKPyV) is a ubiquitous childhood infection that persists in the kidney during adulthood and is frequently detected in urine.
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5 Paradigm Shifts on How to Grow Small Groups

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By Andrew Mason
| Church Leaders
While the phrase “paradigm shift” may be used and heard a lot today, the actual occurrence of one is still a rare sight. A paradigm shift can be defined as a dramatic change by members of a group or community in the cognitive framework of basic assumptions, ways of thinking, underlying suspicions and methodology. I believe a true paradigm shift on how to grow small groups can release a desperately needed disciple-making revolution in our churches.
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