Andrew T Magis

Abstract The Genomic Medicine for Everyone (Geno4ME) study was established across the seven-state Providence Health system to enable genomics research and genome-guided care across patients’ lifetimes. We included multi-lingual outreach to underrepresented groups, a novel electronic informed consent and education platform, and whole genome sequencing with clinical return of results and electronic health record integration for 78 hereditary disease genes and four pharmacogenes.

Keywords conserved immune dysregulation multi-omics multi-cohort analysis sepsis risk factors for severe infections treatment response prediction impact of lifestyle changes all-cause mortality Introduction Older age,1,2,3 being male,2,4,5,6,7 obesity,8,9,10 smoking,11,12 and co-morbidities such as asthma13,14 and diabetes mellitus8,15,16 have been identified as risk factors for severe outcomes in infectious diseases.

Abstract Variation in the blood metabolome is intimately related to human health. However, few details are known about the interplay between genetics and the microbiome in explaining this variation on a metabolite-by-metabolite level. Here, we perform analyses of variance for each of 930 blood metabolites robustly detected across a cohort of 1,569 individuals with paired genomic and microbiome data while controlling for a number of relevant covariates.