Jiaying Toh

Keywords conserved immune dysregulation multi-omics multi-cohort analysis sepsis risk factors for severe infections treatment response prediction impact of lifestyle changes all-cause mortality Introduction Older age,1,2,3 being male,2,4,5,6,7 obesity,8,9,10 smoking,11,12 and co-morbidities such as asthma13,14 and diabetes mellitus8,15,16 have been identified as risk factors for severe outcomes in infectious diseases.

Introduction Epstein-Barr virus (EBV) is a broadly disseminated gamma-1 herpesvirus estimated to infect 90%–95% of adults globally.1,2 EBV infection is mostly asymptomatic, with the virus proceeding through a complex life cycle including a productive lytic phase but ultimately establishing a latent infection in a subset of memory B cells.3 In this manner, EBV persists for the lifetime of the host, though periodic reactivation of EBV drives further lytic replication and viral transmission.

New Results doi: https://doi.org/10.1101/2023.06.22.546003 Abstract Viral pandemics and epidemics pose a significant global threat, with emerging and re-emerging viruses responsible for four pandemics in the 21st century alone. While macaques have been utilized as a model for understanding viral disease in a controlled setting, it remains unclear how conserved the antiviral responses to diverse viruses are between macaques and humans.