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Articles by Andy Tran
Weighing the Odds: Body Mass Index and Recurrence-Free Survival in Early-Onset Colorectal Cancer
The authors have declared no competing interest. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The study was conducted on Swedish patients who had given informed consent. Data were de-identified after collection from electronic health records and stored securely.
Cancer stem cells are hyper-responsive sensors of the tumour microenvironment and regulate metastasis dynamics through YAP/TAZ
Abstract Cancer stem cells (CSCs) drive metastasis and therapy resistance, yet their behaviour within the complex tumour microenvironment remains poorly understood. Here we use a fluorescent reporter that marks CSCs to show that CSCs and their more differentiated progeny display strikingly different population dynamics during metastatic lung colonization in breast cancer models.
Vaccination elicits HIV broadly neutralizing antibodies in primates
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Abstract The high antigenic diversity of HIV has been a major obstacle to development of a broadly protective vaccine. Nevertheless, protective HIV broadly neutralizing antibodies (bnAbs) exist and have been proposed as templates for vaccine development1-6.
By Jon M. Steichen, Patrick Madden, Claudia Flynn, Swastik Phulera, Monolina Shil, Oleksandr Kalyuzhniy, Alessia Liguori, Leigh M. Sewall, Christopher A. Cottrell, Krystal M. Ma, Sabyasachi Baboo, Jolene K. Diedrich, Katherine M McKenney, Allan C. deCamp, Diane G. Carnathan, Ivy Phung, Parham Ramezani-Rad, Ester Marina-Zárate, Brian Freeman Verified, Zhenfei Xie, Jeong Hyun Lee, Troy Sincomb, Nicole Phelps Verified, Danny Lu, Diana Goodwin, Ryan Tingle, Nushin Alavi, Jenny Tran, Andy Tran, Daniel Bader, Hannah Voic, Xiaoya Zhou, Grace Pixton, Agnes Walsh, Mariane B. Melo, Torben Schiffner, Facundo D. Batista, Dennis Burton, Darrell J. Irvine, James C. Paulson, John R. III, Gabriel Ozorowski, Andrew Ward, Guido Silvestri, Shane Crotty, William R. Schief, Carolyne Kifude, Yumiko Adachi, Alyne Nascimento, Catherine Sovie
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Nature
Verified
Improving predicted risk of recurrence using molecular profiling in papillary thyroid cancer
Abstract Molecular testing can refine the prediction of cancer recurrence. We sought to compare patterns of gene expression in patients with and without recurrence of well-differentiated thyroid cancer to identify pathways associated with recurrence and develop a predictive model based on gene expression.
PLIN5 phosphorylation orchestrates mitochondria lipid-droplet coupling to control hepatic lipid flux and steatosis
Abstract Steatotic liver disease is common, yet the mechanisms by which hepatocytes cope with surges in dietary fatty acids remain unclear. Here we use single-cell tissue imaging (scPhenomics) and spatial proteomics to map lipid handling across dietary states. Fasting remodeled mitochondria and lipid droplets (LDs), increasing mitochondria–LD contacts, whereas contacts were infrequent in Western diet (WD)-fed male mice.
Control of telomerase recruitment and end protection by independent shelterin components - Nature Communications
Abstract Telomeres are proposed to alternate between “closed” states, in which chromosome ends are protected from DNA damage signaling and inaccessible to telomerase, and “open” states, where they become accessible for telomerase mediated elongation but less protected. Whether these states reflect distinct molecular mechanisms or mutually exclusive structural conformations remains unclear. Here, we develop a single-cell assay to monitor telomerase activity in mouse embryonic stem cells.
NAT10 promotes cancer metastasis by modulating p300/CBP activity through chromatin-associated tRNA
ArticleVolume 85, Issue 24p4526-4544.e18Open access 1Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA 2Protein Characterization Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD, USA 3Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA 4Laboratory of Human Carcinogenesis, National Cancer...
HIV-1 envelope trimer vaccine induces sex-associated differences in antibody responses: a phase 1 clinical trial - Nature Communications
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Abstract A protective vaccine will be the most powerful instrument to reduce HIV-1 infections worldwide and help bring about a lasting end to the AIDS epidemic. The single centre, randomised, open-label, uncontrolled, phase 1 ACTHIVE-001 clinical trial (NCT03961438) aims to assess the safety and immunogenicity of the ConM SOSIP.v7 native-like trimer protein vaccine, based on an HIV-1 group M consensus sequence, in HIV-negative adults.
By Marloes Grobben, Gabriel Ozorowski, Hongmei Gao, Hannah M. Cheeseman, Andy Tran, Jonathan Torres, Ryan Lin, Gyunghee Jo, Dietmar Katinger, John Moore, Rob Hurks, Neeltje A. Kootstra, Gabriella Scarlatti, Andrew Ward, Mathieu Claireaux, Robin J. Shattock, Rogier W. Sanders, Philipp Mundsperger, Michelle Klouwens
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Nature
Verified
Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes - Nature Biomedical Engineering
Abstract Understanding the mechanistic interplay between antibodies and invading pathogens is essential for vaccine development. Current methods are labour and time intensive and limited by sample preparation bottlenecks. Here we present microfluidic electron microscopy-based polyclonal epitope mapping (mEM), which combines microfluidics with single-particle electron microscopy for the structural characterization of immune complexes using small volumes of sera (<4 µl).
Antigen persistence and TLR stimulation contribute to induction of a durable HIV-1-specific neutralizing antibody response - Nature Communications
Abstract HIV-1 Env glycoprotein (Env) immunogenicity is limited in part by structural instability and extensive glycan shielding and is likely the greatest obstacle to an HIV-1 vaccine. Stabilized Env trimers can elicit serum neutralizing antibodies, but the response is short-lived.
Distinct oligomeric assemblies of STING induced by non-nucleotide agonists - Nature Communications
Abstract STING plays essential roles coordinating innate immune responses to processes that range from pathogenic infection to genomic instability. Its adaptor function is activated by cyclic dinucleotide (CDN) secondary messengers originating from self (2’3’-cGAMP) or bacterial sources (3’3’-CDNs). Different classes of CDNs possess distinct binding modes, stabilizing STING’s ligand-binding domain (LBD) in either a closed or open conformation.
Induced clustering of SHP2-depleted tumor cells in vascular islands restores sensitivity to MEK/ERK inhibition
ResearchAngiogenesisOncology Open Access | 10.1172/JCI181609 J Clin Invest. https://doi.org/10.1172/JCI181609. Copyright © 2025, Wang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Mechanism for local attenuation of DNA replication at double-strand breaks - Nature
Abstract DNA double-strand breaks (DSBs) disrupt the continuity of the genome, with consequences for malignant transformation. Massive DNA damage can elicit a cellular checkpoint response that prevents cell proliferation1,2. However, how highly aggressive cancer cells, which can tolerate widespread DNA damage, respond to DSBs alongside continuous chromosome duplication is unknown.
A modified mycobacterial growth inhibition assay for the functional assessment of vaccine-mediated immunity - npj Vaccines
Abstract The Mycobacterial growth inhibition assay (MGIA) is an ex-vivo assay used to measure the overall functional immune response elicited by infection or vaccination. In tuberculosis (TB) vaccine development, MGIA is a potentially important tool for preclinical evaluation of early-stage vaccine candidates to complement existing assays, and to potentially reduce the need for lengthy and costly pathogenic Mycobacterium tuberculosis (Mtb) animal challenge experiments.
Specific Cationic Antimicrobial Peptides Enhance the Recovery of Low-Load Quiescent Mycobacterium tuberculosis in Routine Diagnostics
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Inhibition of human cytomegalovirus replication by interferon alpha can involve multiple anti-viral factors
Article metrics loading... /content/journal/jgv/10.1099/jgv.0.001929 Download as PowerPoint /deliver/fulltext/jgv/104/12/jgv001929.html?itemId=/content/journal/jgv/10.1099/jgv.0.001929&mimeType=html&fmt=ahah References Griffiths P, Reeves M. Pathogenesis of human cytomegalovirus in the immunocompromised host. Nat Rev Microbiol 2021; 19:759–773 [View Article] [PubMed] [Google Scholar] Coen DM, Schaffer PA. Antiherpesvirus drugs: a promising spectrum of new drugs and drug targets.
Construction and optimization of multi-platform precision pathways for precision medicine
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Scalable workflow for characterization of cell-cell communication in COVID-19 patients
Loading metrics Open Access Peer-reviewed Research Article Abstract COVID-19 patients display a wide range of disease severity, ranging from asymptomatic to critical symptoms with high mortality risk. Our ability to understand the interaction of SARS-CoV-2 infected cells within the lung, and of protective or dysfunctional immune responses to the virus, is critical to effectively treat these patients.
Cellulose Nanocrystal Elastomers with Reversible Visible Color
Communication PDF PDF Share Abstract Responsive photonic crystals have potential applications in mechanical sensors and soft displays; however, new materials are constantly desired to provide new innovations and improve on existing technologies. To address this, we report stretchable chiral nematic cellulose nanocrystal (CNC) elastomer composites that exhibit reversible visible color upon the application of mechanical stress.
16 Minutes on the News #11: CRISPR! Policy, Platform, Trials
This is the 11th episode of 16 Minutes, a weekly show where we quickly cover the top headlines of the week, the a16z Podcast way: why are these topics in the news; what’s real, what’s hype — from our vantage point in tech. This week, we do a 20-ish minute deep-dive on CRISPR, to tease apart the FUD from the facts given a bunch of recent news (not research!) around the gene-editing platform.
Engineering the Genome: Challenges and Opportunities in the Next Wave of Medicine
Technology’s ability to rewrite our genetic code is becoming one of the most powerful therapeutic arsenals of all time. We’ve gone from small molecules, to antibodies, to using biological machinery itself as we engineer our genomes to treat diseases. This is a huge paradigm shift, as these “living medicines” have given us the power to precisely target, eliminate, and even potentially cure disease—with a single dose of a drug.
The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening
Abstract The growth of telomerase-deficient cancers depends on the alternative lengthening of telomeres (ALT), a homology-directed telomere-maintenance pathway. ALT telomeres exhibit a unique chromatin environment and generally lack the nucleosome remodeler ATRX, pointing to an epigenetic basis for ALT. Recently, we identified a protective role for the ATRX-interacting macroH2A1.2 histone variant during homologous recombination and replication stress (RS).
Unwinding a spiral of cellulose nanocrystals for stimuli-responsive stretchable optics
Abstract Cellulose nanocrystals (CNCs) derived from biomass spontaneously organize into a helical arrangement, termed a chiral nematic structure. This structure mimics the organization of chitin found in the exoskeletons of arthropods, where it contributes to their remarkable mechanical strength. Here, we demonstrate a photonic sensory mechanism based on the reversible unwinding of chiral nematic CNCs embedded in an elastomer, leading the materials to display stimuli-responsive stretchable optics.
Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
Using an RNA interference-based screen for HR modulators, we have previously identified USP21 as a potential positive effector of HR27 (Supplementary Fig. 1A). To validate the primary screen results and further dissect the impact of USP21 on DSB repair, we performed both overexpression and knockdown of USP21 in a DRGFP-based HR reporter cell line, which allows for doxycycline (Dox)-dependent induction of I-SceI endonuclease-mediated DSBs27.
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Relative contribution of medullary thymic epithelial cells and dendritic cells to thymocyte central tolerance as assessed by multi-photon microscopy
Following positive selection, thymocytes migrate into the medulla where they encounter diverse tissue-restricted antigens (TRAs) that induce self-tolerance. Both medullary thymic epithelial cells (mTECs) and dendritic cells (DCs) present TRAs to induce negative selection of autoreactive thymocytes, but their relative contribution remains unresolved. Previous studies using genetic models to impair antigen presentation by mTECs or DCs demonstrated both cell types could induce negative selection.
The Team - 001
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The Team - Grid
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SVG Animation - Elegant Themes
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Graph Animation
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Pure CSS - Task App
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Pure CSS - Menu App
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Simple Card Carousel
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Pure CSS - Alarm App
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CodePen User Card
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Planner Dashboard
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3d Elevated Card
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Dropdown Button :: Pure CSS
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ElegantThemes - Animated SVG Logo
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Divi - SVG Loading Animation
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Extra - Animated SVG Logo
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Information Card Slider
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Day 21 - Interactive Dribbble Invite Modal
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Minion Animation
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Forkology
Just a parody of a website that "forked" a plugin....
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