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Anna Cox

As seen in: Medium, The Daily Mirror, Wiley Online Library, PLOS, The Conversation, BMC Psychology, Yahoo, BioRxiv, Cell Reports, Nursing Times and
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Articles

Recurrent ZC3H18 mutations stabilize oncogenic endogenous retroviral RNA

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By Tanzina Tanu, Anna Cox, Jennifer Karlow, Priyanka Sharma, Kaiwen Sun, Xueyang He, Madeline K. Roelofs, Ethan Jeon, JiaJia Chen, Constance Wu, Jared Brown, Nelson B. Barrientos, Andrew S. McCallion, Kevin Brown, Stephen J. Chanock, David R. Liu, Tongwu Zhang, Kathleen Burns, Paul L. Boutz, Megan L Insco
| Cell Reports Verified
Keywords endogenous retroviral RNA ERV RNA melanoma nuclear exosome targeting complex NEXT complex nuclear RNA surveillance zebrafish Research topic(s) CP: cancer CP: molecular biology Introduction As healthy cells require appropriate levels of high-quality RNA, dysregulation of RNA homeostasis contributes to diverse human diseases, including cancer. RNA homeostasis requires balanced production and degradation.
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The Dark Story Behind “Gotta Let Go” Music Video by Tina Moreni

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By Anna Cox
| Medium
Released in early 2025, “Gotta Let Go” by Tina Moreni is the 3rd track to her debut EP “Too Young To Care”. It is most recognized for its powerful message of emotional resilience. Critics praised the song for its heartfelt lyrics and catchy production, highlighting Moreni’s growth as both a vocalist and songwriter. Upon its release, “Gotta Let Go” resonated with listeners, earning positive reviews and charting on several streaming platforms.
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Recurrent oncogenic ZC3H18 mutations stabilize endogenous retroviral RNA

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By Anna Cox, Priyanka Sharma Verified, Tanzina Tanu, Jennifer Karlow
| BioRxiv
Abstract Endogenous retroviral (ERV) RNA is highly expressed in cancer, although the molecular causes and consequences remain unknown. We found that ZC3H18 (Z18), a component of multiple nuclear RNA surveillance complexes, has recurrent truncating mutations in cancer. We show that Z18trunc mutations are oncogenic and that Z18 plays an evolutionarily conserved role in nuclear RNA surveillance of ERV RNA. In zebrafish, Z18trunc expedited melanoma onset and promoted a specific accumulation of ERV RNA.
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