Barry Whyte
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Tyrone, Ulster
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Chief Reporter for BMAI. Got a story anywhere in Ireland, get in touch Barry.Whyte@newstalk.com Threema - NN5YSC8D
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Articles by Barry Whyte
The Thioflavin T assay (ThT assay) for monitoring amyloid formation
Introduction Thioflavin T (ThT) is a small, fluorescent molecule (a benzothiazole dye) that binds quantitatively to sites in the grooves created by beta-sheet-rich structures found in some aggregated proteins (Fig.1). ThT typically generates increased fluorescence when it binds to these sites on cross beta-sheet-rich proteins. This type of interaction occurs for proteins like amyloids that are thought to play a crucial role in many diseases.
Metabolic flux: the dynamic flow of biochemical reactions
Introduction to metabolic flux analysis Metabolism is universal to all cells and involves thousands of metabolites distributed through interconnected pathways.1-4 This has important consequences for the viability of a cell.
Mitochondrial metabolism and cellular function
Introduction Mitochondria are often referred to as the powerhouses of the cell since they produce most of the adenosine triphosphate (ATP) that serves as the primary energy source to support cellular function. However, the contribution of mitochondrial metabolism to cellular function is not limited to the production of ATP. Mitochondrial metabolism is essential on many fronts including crucial anabolic and catabolic processes that provide diverse molecules and energy sources to support life.
Understanding metabolism in cancer
The tumor microenvironment is a dynamic and complex ecosystem that plays a pivotal role in cancer development, progression, and therapeutic response. Composed of a diverse array of cell types — including cancer cells, immune cells, stromal cells, and vascular cells — the tumor microenvironment forms a supportive network that not only nurtures tumor growth but also shapes the metabolic fate of cancer cells (Fig.
Receptor-ligand kinetics for research and drug discovery
Introduction Receptor-ligand interactions are molecular binding events that alter receptor activity or trigger a response in the cell. Researchers are interested in studying receptor-ligand interactions to understand how cells communicate with their environment and how they operate in response to cell signaling. Receptor-ligand interactions are also an important target for drug discovery (Fig.
Receptor-ligand interactions
Introduction A receptor-ligand interaction involves the binding of a molecule (ligand) to a site on a receptor. Receptors are detection and cell signaling molecules inextricably linked to the activities of cells1. Ligands are diverse molecules with the ability to interact with receptors. They may be endogenous (naturally occurring) molecules or synthetic ligands such as drugs. Receptor-ligand interactions are crucial on two fronts.
Binding constants on a microplate reader
Introduction This blog is about binding constants (association, dissociation or equilibrium constants), how to measure them, and the crucial role they play in understanding molecular interactions. By definition, a binding constant quantifies the strength of the interaction between two molecules, such as a ligand and its binding partner, under equilibrium conditions.
Luanda, Angola: A first impression I will never forget
My first impression of Luanda was, frankly, one of the worst I have ever had of any country — and I’ve been fortunate enough to visit around thirty. Barely twenty minutes after leaving Dr. António Agostinho Neto International Airport , our taxi slowed on the three-lane motorway. Two cones stood in the centre lane. I assumed an animal had been hit. But as we edged past, the truth emerged: it wasn’t an animal. It was a young man, lying dead on the tarmac, likely struck as he tried to cross the road.
Endpoint and kinetic modes on a microplate reader
When scientists carry out experiments, they often use technologies and assays to make critical measurements in the laboratory. Accuracy is crucial but there is also often a need to make as many robust measurements as possible in the shortest possible timeframe. Microplate readers allow researchers to perform many different types of assays in a way that is consistent with these requirements for automation and performance.
Dundalk crash victims named by Gardaí
Gardaí have named the five young people who died in a road crash in Dundalk in Co Louth. The group were travelling to the Dundalk area for a night out when the crash occurred. The three men and two women who died were all in their early 20s and were from a number of areas across the northeast.
The monocyte activation test
Monocyte activation tests on a microplate reader As mentioned earlier, monocytes activated by pyrogens produce cytokines that can be detected by either immunological assays or gene reporter assays each with different throughput options on a microplate reader. Monocytes from different sources can be used for these assays.
The rFC Test or Recombinant Factor C Test
For many years, LAL has been the method traditionally used for endotoxin testing. However, it relies on the use of blood samples taken from the horseshoe crab. Two main species have been used as sources: Limulus polyphemus from the North Atlantic and Tachypleus spp. from Asia. Blood is collected in both cases from live animals and used as a source of an amebocyte-rich fraction (amebocytes are cells found in invertebrates that play a role in the defense against pathogens).
Searches resume in Offaly as part of Fiona Pender murder investigation
Searches of bogland in Co.Offaly have resumed this morning as part of the investigation into the murder of Fiona Pender. She went missing in 1996. Gardai are searching a remote rural area near Killeigh village, about 10km outside Tullamore. The area is being excavated and forensically and technically examined over the coming days. Fiona Pender, who was 25 when she went missing, was last seen on 23 August 1996 at her flat on Church Street in Tullamore.
Pyrogens and pyrogen testing
In most cases, the different toll-like receptors on the cell surface use myeloid differentiation primary-response protein (MyD88) as one of the first proteins in the cascade of signaling reactions that are possible within the cell.
14% of international protection applications made at Dublin Airport
14% of international protection applications in Ireland so far this year were made at Dublin Airport, according to new figures released by the Department of Justice. 3,195 asylum seekers have arrived in Ireland up until April 4th. This is a significant reduction on the first three months of last year when 5,151 people applied for international protection up until the end of March 2024.
Man sentenced after beating best friend to death with baseball bat
A man who beat his friend to death with a baseball bat has been sentenced to life in prison. 30-year-old Robert Broughan of St Patrick's Park, Rathangan in County Kildare, was sentenced today for the murder of Roy Hopkins on July 31st, 2020. The pair had gone fishing together on the Grand Canal when Mr Broughan turned on his friend and killed him.
Extra Gardaí deployed in Dublin city centre to crack down on crime
Extra Gardaí patrolling the streets of Dublin have been told to get tough on crime. A new policy of increased visibility has been introduced in the capital with a focus on tackling anti-social behaviour, drug dealing, aggressive begging, thefts and shoplifting. Foot patrols will be concentrated on O’Connell St, Henry St, Talbot St and Bachelor Quay in particular, following Garda engagement with the community and business owners.
Discriminatory policing and racial profiling in Ireland identified in new study
People of African descent and Brazilians in Ireland experience widespread discriminatory policing and racial profiling, a new study has found. The report by the Irish Network Against Racism was commissioned and funded by the Policing Authority. It draws on data gathered between April 2023 and January 2024 from a national online survey of almost 200 people who identified either as African or of African descent or Brazilian.
Justice department to process all asylum applications within 6 months
The Department of Justice has committed to processing all asylum applications within six months, with international protection applicants from safe countries to be handled in just twelve weeks. The plans for implementing the EU Migration and Asylum Pact was published yesterday evening and has been submitted to the European Commission. The Government hoped that the plan to speed up processing times could eventually take the pressure off the system to source accommodation.
Payment for property owners housing Ukrainian refugees to be cut
The payment to property owners who provide places to live for Ukrainian refugees is to be cut. It is being reduced from €800pm to €600pm under a proposal that went before Cabinet earlier today - and will continue for a year. The Accommodation Recognition Payment (ARP) was first introduced three years ago to recognise the generosity of people who provided rooms in their homes or provided properties for Ukrainian refugees.
Conor McGregor seeks to bring new evidence against Nikita Hand
Conor McGregor will seek to bring in new evidence as part of his appeal against a civil jury’s finding that he raped a woman. Last November, a jury found the multi-millionaire MMA fighter raped Nikita Hand in a Dublin hotel six years ago. The Court of Appeal heard today that the former UFC World Champion wants to order a retrial of the case taken against him by Ms Hand. Ms Hand sued McGregor for damages in the high court over an incident in the Beacon Hotel in South County Dublin in December 2018.
McGregor's appeal against Nikita Hand verdict begins today
Conor McGregor's attempt to overturn the verdict in the civil rape case taken against him by Nikita Hand will come before the Court of Appeal today. Last November, a jury found that the mixed martial arts fighter assaulted Ms Hand in a Dublin hotel over six years ago. Conor McGregor was deemed liable for sexually assaulting Nikita Hand in the Beacon Hotel in Dublin on December 9th, 2018. The jury in the case awarded Ms Hand over €248,000 in damages.
Woman jailed for 2 years after high speed pursuit endangered Garda's life
A 28-year-old woman, who endangered the life of a Garda during a high speed pursuit, has been sentenced to two years in prison. Gemma Greene of Bunratty Road, Coolock, Dublin pleaded guilty to a number of charges, including recklessly engaging in conduct in such a manner as to drive in the direction of a Garda. The court heard that on March 1st 2021, Gemma Greene, who was 24-years-old at the time, led Gardaí on an hour long high speed pursuit on the M50.
Kyran Durnin: Gardaí finish their search of Drogheda home
News For the past three days, Gardaí and forensics excavated a backyard, while they also seized electronic devices and documents from the home. The search of a property in Drogheda by Gardaí investigating the disappearance and murder of Kyran Durnin has ended. Kyran was last seen in 2022 when he was six years old; however, it is believed he may have died over two years ago.
DCC spends €170,000 on metal barriers
News The barriers were then erected to stop international protection applicants from pitching tents again in the area. Metal barriers in and around Mount Street in Dublin have cost the City Council €170,000 so far. The fencing was erected last May, after tents for more than 200 asylum seekers were dismantled and removed from Mount Street as part of a multi-agency operation. The barriers were then erected to stop international protection applicants from pitching tents again in the area.
Mount Street building could see €16.5m profits as asylum seeker accommodation
A vacant building in Dublin City Centre close to the International Protection Office is set to be converted into accommodation for refugees - and could see profits of €16.5 million. The Business Post’s Senior Business Reporter Killian Woods said up to 700 asylum seekers could be accommodated in the building.
What is Protein Nitration?
Proteins catalyze a wide range of reactions in the cell and play important structural roles. Post-translational modification of proteins, which includes the alteration of certain amino acid side chains by the introduction of different chemical groups, takes place in eukaryotic and prokaryotic cells. Protein nitration is one example that takes place on tyrosine residues which can have important consequences for the regulation of biological processes.
The Z prime value (Z´)
Scientists depend on high-quality biological assays for reliable and fast measurements. But how do you ensure the quality of these assays, especially if you are working at scale? Z prime value or Z prime factor, which is also referred to as Z’, is one crucial parameter for measurements in the life sciences particularly for data acquisition in high throughput screening in drug discovery. But what is the Z prime value exactly and how is it determined?
Man charged with murder of Malika Al Katib
A 34-year old man has appeared in court charged with the murder of his 8-year-old daughter Malika Al Katib in County Wexford. Muhammad Shaker Al Tamimi appeared in court this evening. He is charged with the murder of his 8-year-old daughter Malika Noor Al Katib at Lower William Street, New Ross, Co Wexford on Sunday night. He is also charged with the attempted murder of his partner and Malika's mother Aisha Al Katib on Sunday night.
Malika Noor Al Katib: 8-year-old to be laid to rest today
An eight-year-old girl who was killed in County Wexford on Sunday will be laid to rest today. Imam Rashid Munir of the Waterford Islamic Centre said Malika's mother, who was also injured in the incident, will attend the burial. "That mother, she's out of danger now," he said. "She's not in critical condition, but she's in bits. "Obviously, it's not easy [that] somebody has to suffer this.
farmers eye age-old wealth, but at what cost?
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Creeslough families to meet with Justice Minister in Dublin
News The families are concerned their calls for an independent public inquiry could be forgotten when a general election is called. A group representing families impacted by the Creeslough tragedy will meet with the Justice Minister today. Ten people died in an explosion in the County Donegal village on October 7th, 2022.
Kyran Durnin: Gardaí find no evidence after Dundalk search
Gardaí have completed a dig of wasteland in Dundalk for missing Kyran Durnin. The eight-year-old boy was reported missing around six weeks ago but Gardaí now believe he was last seen over two years ago. After two days of searching an area of wasteland near the former Durnin family home, it is understood that they have found no evidence linked to Kyran's disappearance. The Garda Technical Bureau left the scene a short while ago.
Locals 'in shock' as the search for missing child Kyran Durnin continues
Gardaí are continuing to search an area of wasteland near the former family home of Kyran Durnin in Dundalk. Forensic experts have been on site at the property at Emer Terrace in the town since yesterday, and the search is expected to continue tomorrow. The current occupants of the house are not connected in any way to Kyran or his disappearance. A local man said everyone living in the area is in a state of shock. “It's absolutely crazy, especially for the community as well,” he said.
Taoiseach 'utterly horrified' by the Kyran Durnin case
The case of Kyran Durnin has "utterly horrified" Taoiseach Simon Harris, as the murder investigation continues in Dundalk. Simon Harris said he cannot comprehend how an eight-year-old boy could disappear like this. "For any of us as a human being, for any of us as a parent, to think that a child can affectively dissapear, go unnoticed, and not be noticed that they're not there is utterly heartbreaking," the Taoiseach said. "Clearly something went extraordinarily wrong here," he said.
Reimagining Dublin: Did we really need a taskforce to tell us this?
The Dublin City Taskforce has made a range of recommendations for cleaning up the capital – from drafting in 1,000 extra Gardaí to expanding the CCTV network and tackling on-street drug use. The group, which was established last May to revitalise the capital in the wake of the November 2023 riots and the Covid-19 pandemic, has made a total of ten recommendations. I don’t think many people would disagree with most of these proposals.
Gene reporter assays
Gene reporter assays are widely used by researchers to investigate gene expression and regulation. They find many uses in the life sciences from studying promoters and enhancers to screening for drugs or investigating signal transduction pathways. Gene reporter techniques rely on the use of a reporter gene typically placed downstream of a regulatory sequence.
Kyran Durnin: Gardaí piecing together disappearance timeline
Gardaí investigating the disappearance of young Drogheda Boy Kyran Durnin are focusing their investigation on where and when he was last seen. Earlier this week, investigators upgraded the case to a murder inquiry – noting that they have “no information” on the eight-year-old’s whereabouts or “any evidence that he is currently alive”. The boy was reported missing around six weeks ago; however, Gardaí now believe he was last seen over two years ago.
Three arrested after toddler's murder in Tyrone
News 23-month-old Tavia Michella Ximenes Da Costa was found dead by police in the Windmill Court area of Dungannon on Sunday morning. A murder investigation is underway following the death of a young child in Dungannon, County Tyrone. 23-month-old Tavia Michella Ximenes Da Costa was found dead by police after they were called to the Windmill Court area of the town on Sunday morning. Following the results of a post mortem examination, the PSNI said it is treating the death as a murder.
Gardaí fear missing child has been murdered
News Gardai now suspect that the missing 8-year-old may have died several months ago and have started a murder investigation. Gardaí fear a missing child in County Louth may have been murdered. Kyran Durnin was reported missing, along with his mother, at the end of August but it is now thought that he died months before his disappearance. Ms Durnin has since been located alive in England but Gardaí have been unable to find her son.
Asylum seekers to move into Thornton Hall this month - McEntee
Asylum seekers will begin moving into the Thornton Hall site in Dublin later this month, the Justice Minister has confirmed. The site in North County Dublin, which was once earmarked as the location of a new super prison, is set to accommodate up to 1,000 international protection applicants when complete. The tented accommodation at the site will be opened a phased basis for single adult men who are seeking international protection.
Asylum seeker tents burned in ‘horrific’ attack on Dublin’s Grand Canal
Gardaí are investigating after asylum seeker tents were attacked and burned in Dublin yesterday. The victims had been sleeping rough along the Grand Canal before the attack at Clanwilliam Place yesterday afternoon. No one was injured in the fires. Tiglin homeless charity co-founder Aubrey McCarthy told Newstalk it appears to have been an attack on asylum seekers. "Our outreach team contacted me yesterday and they were telling me there was an incident just after lunch," he said.
Tipperary Co-op sales fell by €116m in 2023 during ‘difficult 12 months’
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Tipperary Co-op sales fell by €116m in 2023 during ‘difficult 12 months’
These cookies are set by a range of social media services that we have added to the site to enable you to share our content with your friends and networks. They are capable of tracking your browser across other sites and building up a profile of your interests. This may impact the content and messages you see on other websites you visit. If you do not allow these cookies you may not be able to use or see these sharing tools.
Monochromator vs. Spectrometer | BMG LABTECH
The fundamental observation that almost all molecules in nature absorb and emit light at different wavelengths has driven developments in spectroscopy and fueled discoveries across scientific disciplines. 1 Today researchers have access to technologies and instruments that use different forms of light to generate precise measurements of how much of a particular substance is present in a solution.
The minimum bactericidal concentration of antibiotics
Introduction The minimal bactericidal concentration (MBC) is a quantitative metric that can be used to assess the effect of antibacterial agents on microorganisms. Whereas the minimum inhibitory concentration (MIC) indicates the lowest concentration needed to inhibit bacterial growth, the MBC indicates the lowest concentration needed to kill bacteria.
Religious orders should ‘step up’ with redress for abuse victims - Taoiseach
Religious orders that ran schools implicated in child sexual abuse should “step up” and commit to a redress scheme, the Taoiseach has said. While welcoming “statements of regret” from institutions, Simon Harris said they will be “hollow words” without further action. It follows the release of a 700-page report into allegations of historical sexual abuse at some schools yesterday, containing over 2,400 allegations and involving 884 alleged abusers.
Harris in Kyiv: Taoiseach tells Zelenskyy Ireland ‘will always stand with Ukraine’
The Taoiseach has promised that Ireland will “always stand with Ukraine” on a State visit to Kyiv. Simon Harris is currently in Kyiv and met with President Zelenskyy within the last hour.
Government announces €36m for Ukraine as Harris visits Kyiv
The Irish Government has announced a significant new package of financial support for Ukraine. The €36m in funding will provide essential humanitarian assistance and eventual reconstruction, while also contributing to Ukraine's longer-term goals, including peace and stability. The Taoiseach is visiting Ukraine today for the first time after travelling from southeast Poland to Ukraine by overnight train.
Woman charged over death of her partner in Balbriggan
News 48-year-old Olesja Hertova is charged with causing serious harm to father of four James Ryan, A woman has been charged in connection with the death of her partner in Dublin earlier this month. 48-year-old Olesja Hertova, with an address at Hasting Lawns, Balbriggan, this afternoon appeared at Dublin District Court in relation to the death of James Ryan. Ms Hertova was charged with causing serious harm to James Ryan, a father of four and grandfather.
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