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Articles by Benjamin Hale
Analysis of West Nile disease convalescents identifies human monoclonal antibodies protective against West Nile and related orthoflaviviruses
Keywords West Nile virus Japanese encephalitis serocomplex orthoflaviviruses neutralizing human monoclonal antibodies envelope domain III autoantibodies type I interferon Introduction West Nile virus (WNV; Orthoflavivirus nilense) is one of many orthoflaviviruses (genus Orthoflavivirus) transmitted by Culex spp.
Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections
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Keywords type-I interferon B cells antibodies COVID-19 autoimmunity Sars-CoV-2 affinity maturation memory B cells severe viral infections Get full text access Log in, subscribe or purchase for full access. References 1. Crow, Y.J. ∙ Casanova, J.-L. Human life within a narrow range: The lethal ups and downs of type I interferons Sci. Immunol. 2024; 9, eadm8185 2. Bastard, P. ∙ Gervais, A. ∙ Le Voyer, T. ...
By Morgane Fournier, Matthias Vanderkerken, Karim Dorgham, Paul Bastard, Olivia Ahouzi, Stephane Duquerroy, Ngoc Nguyen Verified, Ngọc Nguyễn, Manon Broutin, Manon Charlet, Alexis Vandenberghe, Paolo Van Endert, Lucy Bizien, Omaira Da Mata-Jardin, Andrés Ferriño-Iriarte, Ahmed Haouz, Thibaut Belmondo, Sophie Hue, Alessandro Borghesi, Carlos Rodríguez-Gallego, Donald C. Vinh, Evangelos Andreakos, Filomeen Haerynck, Rabih Halwani, Qiang Pan-Hammarström, Niklas K. Björkström, Benedikt Strunz, Trine H. Mogensen, Antonio Piralla, Stefania Varchetta, Jorge Freixinet, Lucie Roussel, Sophie Trouillet Assant, Bénédicte Neven, Romain Lévy, Tom Le Voyer, Ottavia Delmonte, Cliona O’Farrelly, Jacques Rivière, Blanca Amador Borrero, Amélie Servettaz, Roger Kouyos, Daniel Kaufmann, Etienne Crickx, Marc Michel, Anne Puel, Laurent Abel, Charles-Edouard Luyt, Alexis Mathian, Kai Kisand, Darragh Duffy, Lluis Quintana-Murci, Zahir Amoura, Benjamin Hale, Jean-Claude Weill, Jean-Laurent Casanova Verified, Félix Rey, Guy Gorochov, Pascal Chappert, Matthieu Mahevas
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Cell Press
Verified
An SP110–SP100 axis is a critical regulator of promyelocytic leukaemia body dynamics and mitotic fidelity
Abstract Stimulation of the innate immune system by foreign RNA elicits a potent interferon response and can trigger cell death. The mechanisms by which cells balance a robust response with cell-intrinsic lethality are still being uncovered. Here, using genome-wide CRISPR–Cas9 genetic screens with triphosphorylated RNA stimulation, we discover that promyelocytic leukaemia (PML) nuclear body-localized speckled protein 110 (SP110) is a potent inhibitor of type 1 interferon-driven cell death.
TRIM28 is a target for paramyxovirus V proteins
Abstract SUMO-modified Tripartite Motif Protein 28 (TRIM28; KAP1) plays a crucial role in repressing endogenous retroelement (ERE) transcription.
Doomsday: Friday, 13 November, A.D. 2026
Information & Authors Information Published In Science Volume 132 | Issue 3436 4 November 1960 Copyright © 1960. Submission history Published in print: 4 November 1960 Permissions Request permissions for this article. Authors Affiliations Heinz von Foerster Department of Electrical Engineering, University of Illinois, Urbana Patricia M. Mora Department of Electrical Engineering, University of Illinois, Urbana Lawrence W.
Electric nuclear quadrupole coupling reveals dissociation of HCl with a few water molecules
Research Article Fan Xie https://orcid.org/0000-0002-0353-2059 melanie.schnell@desy.de, Denis S. Tikhonov https://orcid.org/0000-0003-3167-3104, and Melanie Schnell https://orcid.org/0000-0001-7801-7134 melanie.schnell@desy.deAuthors Info & Affiliations Abstract Investigating the dissociation of acids in the presence of a limited number of water molecules is crucial for understanding various elementary chemical processes.
Localized thermal emission from topological interfaces
Research Article THERMAL PHOTONICS M. Said Ergoktas https://orcid.org/0000-0002-8749-8571, Ali Kecebas https://orcid.org/0000-0003-4257-8460, [...] , Konstantinos Despotelis https://orcid.org/0000-0002-2490-7868, Sina Soleymani https://orcid.org/0000-0002-0216-3095, [...] , Gokhan Bakan, Askin Kocabas https://orcid.org/0000-0002-6930-1202, Alessandro Principi https://orcid.org/0000-0002-4776-6965, Stefan Rotter https://orcid.org/0000-0002-4123-1417, Sahin K.
Retraction
Robert Heilmayr rheilmayr@ucsb.edu, Joan Dudney, and Frances C. MooreAuthors Info & Affiliations On 8 December 2023, Science published the Research Article “Drought sensitivity in mesic forests heightens their vulnerability to climate change” (1). In January 2024, Stefan Klesse, William Anderegg, John Abatzoglou, and Margaret E. K.
Rare codon recoding for efficient noncanonical amino acid incorporation in mammalian cells
Research Article SYNTHETIC BIOLOGY Wenlong Ding https://orcid.org/0000-0001-9681-2027, Wei Yu https://orcid.org/0009-0002-2086-9830, [...] , Yulin Chen https://orcid.org/0000-0001-6174-1580, Lihui Lao, [...] , Yu Fang https://orcid.org/0009-0004-3308-5060, Chengzhu Fang, Hongxia Zhao https://orcid.org/0009-0002-3882-6046, Bo Yang, and Shixian Lin https://orcid.org/0000-0001-9718-9986 sxlin@zju.edu.cn+6 authors +4 authors fewerAuthors Info & Affiliations Editor’s summary Genetic encoding of...
WS2 ribbon arrays with defined chirality and coherent polarity
Research Article MATERIAL SCIENCE Guodong Xue https://orcid.org/0009-0006-4366-2401, Ziqi Zhou https://orcid.org/0000-0002-2946-5069, [...] , Quanlin Guo https://orcid.org/0000-0003-2930-6970, Yonggang Zuo https://orcid.org/0000-0003-1262-6767, [...] , Wenya Wei https://orcid.org/0009-0006-9097-7529, Jiashu Yang https://orcid.org/0009-0002-2195-2310, Peng Yin, Shuai Zhang https://orcid.org/0000-0003-0721-9294, Ding Zhong https://orcid.org/0009-0000-1791-7139, [...] , Yilong You...
Axis formation in annual killifish: Nodal and β-catenin regulate morphogenesis without Huluwa prepatterning
Research Article DEVELOPMENT Philip B. Abitua https://orcid.org/0000-0002-8264-0807 abitua@uw.edu, Laura M. Stump https://orcid.org/0009-0004-5325-8803, [...] , Deniz C. Aksel, and Alexander F. Schier https://orcid.org/0000-0001-7645-5325+1 authors fewerAuthors Info & Affiliations Editor’s summary Development in the annual killifish, Nothobranchius furzeri, reveals a fascinating twist in the story of embryogenesis.
Developing fatigue-resistant ferroelectrics using interlayer sliding switching
Research Article Renji Bian https://orcid.org/0009-0000-7586-3853, Ri He https://orcid.org/0000-0001-6874-8574, [...] , Er Pan https://orcid.org/0009-0004-0319-6763, Zefen Li https://orcid.org/0009-0001-3140-2112, [...] , Guiming Cao, Peng Meng, Jiangang Chen https://orcid.org/0000-0002-3627-3372, Qing Liu https://orcid.org/0000-0003-3937-6251, Zhicheng Zhong https://orcid.org/0000-0003-1507-4814 zczhong@ustc.edu.cn, [...] , Wenwu Li https://orcid.org/0000-0002-9307-1566 zczhong@ustc.edu.cn,...
Ultrafast high-endurance memory based on sliding ferroelectrics
Research Article Kenji Yasuda https://orcid.org/0000-0003-4894-0205 kenji.yasuda@cornell.edu, Evan Zalys-Geller, [...] , Xirui Wang https://orcid.org/0000-0003-4414-1270, Daniel Bennett https://orcid.org/0000-0003-0892-2125, [...] , Suraj S Cheema https://orcid.org/0000-0001-5878-3624, Kenji Watanabe https://orcid.org/0000-0003-3701-8119, Takashi Taniguchi https://orcid.org/0000-0002-1467-3105, Efthimios Kaxiras https://orcid.org/0000-0002-4682-0165, Pablo Jarillo-Herrero...
Cellular architecture shapes the naïve T cell response
2 hours ago Backers of Trump and Biden are deeply divided on issues of immigration, reproductive rights, crime, gun control and other issues. The split among American voters on cultural issues is arguably the widest it has been in decades, according to a new study by the Pew Research Center. The study clearly …
Strong-bonding hole-transport layers reduce ultraviolet degradation of perovskite solar cells
Research Article SOLAR CELLS Chengbin Fei https://orcid.org/0000-0002-8981-091X, Anastasia Kuvayskaya https://orcid.org/0009-0007-8135-7106, [...] , Xiaoqiang Shi https://orcid.org/0000-0003-0284-9588, Mengru Wang https://orcid.org/0000-0003-1864-2207, [...] , Zhifang Shi https://orcid.org/0000-0003-1673-0983, Haoyang Jiao https://orcid.org/0000-0003-2563-1581, Timothy J.
Two-stage evolution of mammalian adipose tissue thermogenesis
Research Article EVOLUTION Susanne Keipert https://orcid.org/0000-0002-6618-7379, Michael J. Gaudry https://orcid.org/0000-0001-8411-0415, [...] , Maria Kutschke, Michaela Keuper https://orcid.org/0000-0003-0319-3509, [...] , Margeoux A. S. Dela Rosa https://orcid.org/0000-0002-9586-763X, Yiming Cheng https://orcid.org/0009-0006-4270-7292, José M. Monroy Kuhn https://orcid.org/0000-0002-4748-8854, Rutger Laterveer https://orcid.org/0000-0003-2016-665X, Camila A.
A tiny, long-distance hunter
Perspective Microbiology Lacrymaria olor cytoskeleton and membrane “origami” enables rapid cell hyperextension Leonardo Gordillo leonardo.gordillo@usach.cl and Enrique Cerda leonardo.gordillo@usach.clAuthors Info & Affiliations Abstract Anglers know that when the goal is distance, winding of the fishing line is as essential as casting technique. When tightly spooled around a reel, a fishing line effortlessly unwinds when the bait is slung.
A new twist in ferroelectric liquids
Perspective Materials Science Spontaneous chirality emerges in a highly polar liquid of achiral molecules Liana Lucchetti l.lucchetti@univpm.itAuthors Info & Affiliations Abstract Liquid crystals are of scientific interest because of their many potential applications in soft matter–based technologies. The most studied liquid crystal phase is the nematic (N), in which molecules possess orientational but not positional order.
Greenhouse gas mitigation requires caution
Perspective Climate Change Strategies to mitigate emissions must consider methane and nitrous oxide together Lisa Y. Stein lisa.stein@ualberta.ca and Mary E. LidstromAuthors Info & Affiliations Methane (CH4) and nitrous oxide (N2O) are greenhouse gases that rank second and third behind carbon dioxide (CO2) as primary contributors to global warming and climate change. Outside of fossil sources, these gases are emitted by microorganisms as they interact with their environment.
The weapons potential of high-assay low-enriched uranium
Policy Forum Nuclear Security Recent promotion of new reactor technologies appears to disregard decades-old concerns about nuclear proliferation R. Scott Kemp rsk@mit.edu, Edwin S. Lyman, [...] , Mark R. Deinert, Richard L. Garwin, and Frank N. von Hippel+2 authors fewerAuthors Info & Affiliations Abstract Preventing the proliferation of nuclear weapons has been a major thrust of international policymaking for more than 70 years.
Abundant hydrocarbons in the disk around a very-low-mass star
Research Article ASTROCHEMISTRY A. M. Arabhavi https://orcid.org/0000-0001-8407-4020 arabhavi@astro.rug.nl, I. Kamp https://orcid.org/0000-0001-7455-5349, [...] , Th. Henning https://orcid.org/0000-0002-1493-300X, E. F. van Dishoeck https://orcid.org/0000-0001-7591-1907, [...] , V. Christiaens https://orcid.org/0000-0002-0101-8814, D. Gasman https://orcid.org/0000-0002-1257-7742, A. Perrin, M. Güdel https://orcid.org/0000-0001-9818-0588, B. Tabone https://orcid.org/0000-0002-1103-3225, [...] , J.
Curved crease origami and topological singularities enable hyperextensibility of L. olor
Research Article CELL DYNAMICS Eliott Flaum https://orcid.org/0000-0001-8737-7967 and Manu Prakash https://orcid.org/0000-0002-8046-8388 manup@stanford.eduAuthors Info & Affiliations Editor’s summary Morphological changes in cellular shape have been studied in the context of cell division, movement through confined spaces, or functionality such as the beating of a heart or digestion within the gut.
Molecular mechanism of substrate recognition and cleavage by human γ-secretase
Research Article STRUCTURAL BIOLOGY Xuefei Guo https://orcid.org/0000-0001-7135-0954, Haotian Li https://orcid.org/0009-0005-4701-0753, [...] , Chuangye Yan https://orcid.org/0000-0001-9338-8048, Jianlin Lei https://orcid.org/0000-0002-9384-8742, [...] , Rui Zhou https://orcid.org/0000-0002-0782-4761 zr2020@tsinghua.edu.cn (R.Z.), and Yigong Shi https://orcid.org/0000-0003-2030-168X zr2020@tsinghua.edu.cn (R.Z.)+3 authors +1 authors fewerAuthors Info & Affiliations Editor’s summary The...
Spontaneous chiral symmetry breaking in polar fluid-heliconical ferroelectric nematic phase
Research Article LIQUID CRYSTALS Jakub Karcz https://orcid.org/0000-0003-4783-0469, Jakub Herman https://orcid.org/0000-0002-5549-7283, [...] , Natan Rychłowicz https://orcid.org/0000-0002-1929-0410, Przemysław Kula https://orcid.org/0000-0002-7862-7968 przemyslaw.kula@wat.edu.pl, [...] , Ewa Górecka https://orcid.org/0000-0002-8076-5489, Jadwiga Szydlowska, Pawel W.
A master regulator of opioid reward in the ventral prefrontal cortex
Research Article NEUROSCIENCE Alexander C. W. Smith https://orcid.org/0000-0001-7724-6234, Soham Ghoshal https://orcid.org/0000-0001-9078-8978, [...] , Samuel W. Centanni https://orcid.org/0000-0002-3941-7677, Mary P. Heyer https://orcid.org/0009-0005-0144-5030, [...] , Alberto Corona https://orcid.org/0000-0002-2258-1905, Lauren Wills https://orcid.org/0000-0002-5018-7315, Emma Andraka https://orcid.org/0000-0002-3013-2384, Ye Lei https://orcid.org/0009-0004-2204-9320, Richard M.
In Other Journals
Hemostasis Cumulative platelet dysfunction in age Sarah H. Ross As people age, they produce more platelets, which increases the risk of blood clots (illustrated). PHOTO: ANNE WESTON, EM STP, THE FRANCIS CRICK INSTITUTE/SCIENCE SOURCE Platelets aggregate to seal damaged blood vessels. The enhanced production of platelets as people age, in combination with their clotting function, is a disease risk. Poscablo et al.
Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
Research Article CANCER Jennifer E. Klomp https://orcid.org/0000-0003-1781-648X, J. Nathaniel Diehl https://orcid.org/0000-0002-7309-0903, [...] , Jeffrey A. Klomp https://orcid.org/0000-0002-5243-6987, A. Cole Edwards, [...] , Runying Yang https://orcid.org/0000-0002-5983-9439, Alexis J. Morales https://orcid.org/0009-0002-3711-934X, Khalilah E. Taylor https://orcid.org/0009-0003-2136-2713, Kristina Drizyte-Miller https://orcid.org/0000-0001-7049-2934, Kirsten L.
Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
Research Article CANCER Jeffrey A. Klomp https://orcid.org/0000-0002-5243-6987 jklomp@unc.edu, Jennifer E. Klomp https://orcid.org/0000-0003-1781-648X, [...] , Clint A. Stalnecker https://orcid.org/0000-0002-0570-4416, Kirsten L. Bryant https://orcid.org/0000-0003-4026-0942, [...] , A. Cole Edwards, Kristina Drizyte-Miller https://orcid.org/0000-0001-7049-2934, Priya S. Hibshman, J. Nathaniel Diehl https://orcid.org/0000-0002-7309-0903, Ye S. Lee https://orcid.org/0000-0001-9026-6192, [...] , Alexis J.
Cellular architecture shapes the naïve T cell response
Research Article IMMUNOLOGY Benjamin D.
Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by PJA2 - Nature Communications
Abstract Deciphering the intricate dynamic events governing type I interferon (IFN) signaling is critical to unravel key regulatory mechanisms in host antiviral defense. Here, we leverage TurboID-based proximity labeling coupled with affinity purification-mass spectrometry to comprehensively map the proximal human proteomes of all seven canonical type I IFN signaling cascade members under basal and IFN-stimulated conditions.
Pyruvate modulation of redox potential controls mouse sperm motility
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Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by the E3 ubiquitin ligase PJA2
Abstract Deciphering the intricate dynamic events governing type I interferon (IFN) signaling is critical to unravel key regulatory mechanisms in host antiviral defense. Here, we leveraged TurboID-based proximity labeling coupled with affinity purification-mass spectrometry to comprehensively map the proximal proteomes of all seven canonical human type I IFN signaling cascade members under basal and IFN-stimulated conditions.
Challenges on the development of a dengue vaccine: a comprehensive review of the state of the art
Abstract Dengue virus (DENV) is the mosquito-borne virus of greatest human health concern. There are four serotypes of DENV (1-4) that co-circulate in endemic areas. Each serotype of DENV is individually capable of causing the full spectrum of disease, ranging from self-resolving dengue fever to the more severe dengue haemorrhagic fever (DHF) or dengue shock syndrome (DSS). Based on data published by the CDC, one in four people who become infected with dengue will become ill.
The health of influenza surveillance and pandemic preparedness in the wake of the COVID-19 pandemic
Abstract The COVID-19 pandemic is the first to have emerged when Next Generation Sequencing was readily available and it has played the major role in following evolution of the causative agent, Severe Acute Respiratory Syndrome Coronavirus 2.
Multiplexed high-throughput immune cell imaging reveals molecular health-associated phenotypes
LATEST NEWS Abstract Phenotypic plasticity is essential to the immune system, yet the factors that shape it are not fully understood. Here, we comprehensively analyze immune cell phenotypes including morphology across human cohorts by single-round multiplexed immunofluorescence, automated microscopy, and deep learning.
SARS-CoV-2 takes the bait: Exosomes as endogenous decoys
From the beginning of the Coronavirus Disease 2019 (COVID-19) pandemic, researchers have studied various aspects of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) biology. Among these, determining key host factors required for virus replication in human cells, as well as assessing how the body naturally fights infection, have been critical to understand pathogenesis, disease susceptibility, and therapeutic opportunities.
Highlights • An siRNA screen identifies genes contributing to the antiviral action of interferon • RABGAP1L potentiates the action of interferon against multiple RNA viruses • The RABGAP1L proximal interactome reveals its association with endosomal proteins • RABGAP1L disrupts endocytosis to limit cell entry of viruses using this pathway Summary Host interferons (IFNs) powerfully restrict viruses through the action of several hundred IFN-stimulated gene (ISG) products, many of which remain...
Acyl-CoA synthetase 6 enriches seminiferous tubules with the ω-3 fatty acid docosahexaenoic acid and is required for male fertility in the mouse
Benjamin J. Hale‡, Regina F. Fernandez§, Sora Q. Kim¶, Victoria D. Diaz‖, Shelley N. Jackson**, Lei Liu‡‡,§§, J. Thomas Brenna‡‡, Brian P. Hermann‖, Christopher B. Geyer‡,¶¶1 and Jessica M.
Acyl-CoA Synthetase 6 enriches seminiferous tubules with the omega-3 fatty acid DHA and is required for male fertility in the mouse
Benjamin J Hale1, Regina F Fernandez2, Sora Q Kim3, Victoria D Diaz4, Shelley N.
Functional Insights into ANP32A-Dependent Influenza A Virus Polymerase Host Restriction
chANP32A Exhibits Enhanced Interaction with vPol Complexes, which Is Mediated by the SIM-like Sequence and LCAR huANP32A was previously shown to interact with the human-adapted vPol to regulate viral genome synthesis (Sugiyama et al., 2015xpp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA. Sugiyama, K., Kawaguchi, A., Okuwaki, M., and Nagata, K. eLife. ; 4: 1–19 Crossref | Scopus (8)See all ReferencesSugiyama et al., 2015).
Regional and global sea-surface temperatures during the last interglaciation
Jeremy S. Hoffman jhoffman@smv.org, Peter U. Clark, [...] , Andrew C. Parnell, and Feng He+1 authors fewerAuthors Info & Affiliations Sea surface temperatures of the past Understanding how warm intervals affected sea level in the past is vital for projecting how human activities will affect it in the future. Hoffman et al. compiled estimates of sea surface temperatures during the last interglacial period, which lasted from about 129,000 to 116,000 years ago.
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