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Blaine Bartholomew on Muck Rack

Blaine Bartholomew

As seen in: Nature, PLOS Biology, ScienceDirect, BioRxiv, Cell Press, Texas Medical Center, The Journal of Biological Chemistry, CUInsight.com
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Articles

DNA bendability inside the nucleosome regulates INO80’s nucleosome positioning

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By Shagun Shukla, Mzwanele Ngubo, Somnath Paul, Franziska Kunert, Jim Persinger, Junwoo Lee, Karl-Peter Hopfner, Blaine Bartholomew
| Cell Press Verified
Keywords INO80 Arp5 chromatin remodeling nucleosome chromatin transcription DNA ATP-dependent chromatin remodeling, transcription regulation Introduction Transcription, DNA replication, and repair are regulated by ATP-dependent chromatin remodelers that reorganize chromatin to make DNA accessible or alter its composition at specific DNA regions.
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Gene promoters are genomically encoded to facilitate histone exchange/incorporation

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By Blaine Bartholomew
| PLOS Biology Verified
Genomic DNA is package into chromatin by nucleosomes in which DNA is wrapped ~1.7 times around a protein disk comprised of eight histone proteins. As early as 2006, there was evidence for genomic positioning of nucleosomes to be intrinsically determined at the DNA sequence level [1].
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"The SWI/SNF ATP-Dependent Chromatin Remodeling Complex in Cell Lineage" by Dhurjhoti Saha, Srinivas Animireddy et al.

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By Dhurjhoti Saha, Srinivas Animireddy, Blaine Bartholomew
| Texas Medical Center
Abstract ATP dependent chromatin remodelers have pivotal roles in transcription, DNA replication and repair, and maintaining genome integrity. SWI/SNF remodelers were first discovered in yeast genetic screens for factors involved in mating type switching or for using alternative energy sources therefore termed SWI/SNF complex (short for SWItch/Sucrose NonFermentable).
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