A range of clinically impactful studies in renal cell carcinoma (RCC), presented at the American Society of Clinical Oncology Genitourinary Cancers Symposium, underscore the growing promise of hypoxia-inducible factor-2 alpha (HIF-2α) inhibition in this condition, as discussed by Dr Brian Rini of Vanderbilt University School of Medicine in Nashville, Tennessee, who offers insights into these and other abstracts. Dr Rini begins by highlighting two phase 3 trials.