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Articles by Chenyang Lu
Single-cell Profiling of Lymphoid and Myeloid Compartments Reveals Coordinated Immune Dysregulation and Enhanced Monocyte-centric Intercellular Communication in Relapsing Polychondritis
Supporting Information Filename Description art70294-sup-0001-Supinfo.pdfPDF document, 1.5 MB Data S1: Supporting Information
Theory and experiment of chirality-induced magnetic nonreciprocity manifested by the coupling phase
Opens in a new window Opens an external website Opens an external website in a new window This website utilizes technologies such as cookies to enable essential site functionality, as well as for analytics, personalization, and targeted advertising. Privacy Policy Article Text References Phys. Rev. B 114, 024408– Published 6 July, 2026 ©2026 American Physical Society Username Password Enter a citation
Chiari malformation type 1 is associated with a smaller fourth ventricle volume – a multi-cohort replication study
Abstract Chiari Malformation Type 1 (CM1) is canonically defined by ectopic position of the cerebellar tonsils with additional anatomic variations described inconsistently. Effect on fourth ventricle volume is controversial with prior studies reporting disparate results and methodologically limited to single institution series that hinder generalizability.
Post-marketing safety evaluation of mirogabalin using the JADER database
Abstract Background: Mirogabalin, a novel third-generation α2-δ calcium channel ligand, is approved for diabetic peripheral neuropathic pain (DPNP). However, its post-marketing safety profile remains insufficiently characterized, particularly regarding novel signals and comparative safety profiles with established therapies.
Realizing irradiation-resistant metallic alloys by immobilizing induced defects
Abstract Materials capable of withstanding extreme conditions are essential for advanced fission and fusion technologies. The development of irradiation-tolerant structural materials hinges on the suppression of defect evolution that could lead to mechanical degradation. In this study, we present a novel strategy to effectively immobilize irradiation-induced defects through tuning the degree of local lattice distortion, an intrinsic characteristic of concentrated solid solution alloys.
Iron overload reprogramming lipid metabolism through the IRP1–SCAP axis in fibroblast-like synoviocytes aggravates bone destruction in rheumatoid arthritis
Abstract Rheumatoid arthritis (RA) is a leading cause of disability globally. Although iron accumulation in arthritic lesions has been observed in patients with RA, its specific contribution to disability outcomes remains unclear. Here we demonstrate a comprehensive multiomics approach to elucidate the impact and underlying mechanisms of iron overload in RA.
Whispering-gallery-mode resonators for detection and classification of free-flowing nanoparticles and cells through photoacoustic signatures - Light: Science & Applications
Abstract Micro and nanoscale particles have played crucial roles across diverse fields, from biomedical imaging and environmental processes to early disease diagnosis, influencing numerous scientific research and industrial applications. Their unique characteristics demand accurate detection, characterization, and identification.
Patterns of maternal and child health services utilization and associated socioeconomic disparities in sub-Saharan Africa - Nature Communications
Abstract Under-five mortality remains a global health issue, especially in sub-Saharan Africa, where preventable conditions largely drive the high mortality rates. Understanding the heterogeneity in utilization of reproductive, maternal, newborn, and child health services is crucial for reducing under-five mortality.
How to Diagnose and Stage the Progression from Asthma to EGPA
Back to Journals » Journal of Asthma and Allergy » Volume 18 Authors Lu C, Ou C, Deng Y, Li N, Ma Y, Luo J, Zhou J, Chung KF, Deng Z, Zhang Q Received 10 June 2025 Accepted for publication 22 October 2025 Published 11 November 2025 Volume 2025:18 Pages 1615—1626 DOI https://doi.org/10.2147/JAA.S542255 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Luis Garcia-Marcos Chenyang Lu,1,* Changxing Ou,1,* Yu...
Nonreciprocal Control of the Speed of Light Using Cavity Magnonics
We demonstrate nonreciprocal control of the speed of light by sending a microwave pulse through a cavity magnonics device. In contrast to reciprocal group velocity controlled by conventional electromagnetically induced transparency (EIT) effects, incorporating a dissipative magnon-photon coupling establishes a nonreciprocal EIT effect, allowing slow and fast light propagation in opposite directions at the same frequency with comparable amplitude.
Soluble CD13 is a potential mediator of neutrophil-induced thrombogenic inflammation in SARS-CoV-2 infection
ResearchCOVID-19ImmunologyInfectious disease Open Access | 10.1172/jci.insight.184975 JCI Insight. https://doi.org/10.1172/jci.insight.184975. Copyright © 2025, Tsou et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Cyclic Peptide Natural Product Inspired Inhibitors of the Free-Living Amoeba Balamuthia mandrillaris
Balamuthia mandrillaris is a pathogenic and opportunistic amoeba, which causes infections in humans and animals. While the pathobiology is still not well understood, B. mandrillaris can initially cause cutaneous skin lesions or a presumed lung infection followed by systemic spread of infection to the blood–brain barrier (BBB), causing a central nervous system (CNS) disease called Balamuthia amoebic encephalitis (BAE).
Cyclic Peptide Natural Product Inspired Inhibitors of the Free-Living Amoeba Balamuthia mandrillaris
Balamuthia mandrillaris is a pathogenic and opportunistic amoeba, which causes infections in humans and animals. While the pathobiology is still not well understood, B. mandrillaris can initially cause cutaneous skin lesions or a presumed lung infection followed by systemic spread of infection to the blood–brain barrier (BBB), causing a central nervous system (CNS) disease called Balamuthia amoebic encephalitis (BAE).
CRISPRepi: a multi-omic atlas for CRISPR-based epigenome editing
Epigenome editing refers to the selective alteration of chromatin markers at specific genomic loci through the use of targeted epigenetic effectors, including designed DNA recognition domains (zinc finger proteins, TAL effectors or modified CRISPR/Cas9 complexes) and catalytic domains from chromatin modifying enzymes (1).
X-ray fluorescence detection system for trace elements in oil based on graphite curved crystal technology
Curved crystal technology is a key technology in the field of X-ray fluorescence trace detection. To detect trace sulfur, chlorine, and silicon in oil, the key parameters of Johann-type graphite curved crystal design were calculated based on geometrical optics theory and mathematical modeling, and a curved crystal optical system was designed. Subsequently, the hardware, firmware, software, and mechanical structure were designed according to specific requirements.
DAFFNet: A Dual Attention Feature Fusion Network for Classification of White Blood Cells
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Tuna Dark Muscle Feeding Improved the Meat Quality of Holland Mini-Piglets and Modulated the Gut Microbiota
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Discovery of cyclic peptide natural product inhibitors of Balamuthia mandrillaris
Abstract Balamuthia mandrillaris is a pathogenic free-living amoeba that causes infection of central nervous system, called Balamuthia amoebic encephalitis (BAE), as well as cutaneous and systemic diseases. Patients infected with B. mandrillaris have a high mortality rate due to the lack of effective treatments. A combination of non-optimized antimicrobial drug regimen is typically recommended; however, they have poor parasite activity and can cause various severe side effects.
AI 2024
IEEE Impact Creators shed light on why AI needs human oversight to function effectively. What does it mean for AI to be a tool or an assistant, rather than a replacement? “Some people excel in programming, others thrive in content writing, data analysis or creative endeavors. With AI, this diversity can be leveraged to bridge gaps, allowing individuals to enhance their abilities without the burden of being all-rounders.” Close What skills help people work with AI more effectively?
Single-cell transcriptome analyses reveal disturbed decidual homoeostasis in obstetric antiphospholipid syndrome
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Prescribing Large Language Models for Perioperative Care: What's The Right Dose for Pre-trained Models?
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Hypoglycemic effects and associated mechanisms of resveratrol and related stilbenes in diet
Hypoglycemic effects and associated mechanisms of resveratrol and related stilbenes in diet† Hyperglycemia has become a global health problem due to changes in diet and lifestyle. Most importantly, persistent hyperglycemia can eventually develop into type II diabetes. While the usage of current drugs is limited by their side effects, stilbenes derived from fruits and herbal/dietary plants are considered as important phytochemicals with potential hypoglycemic properties.
Single-cell transcriptome analyses reveal disturbed decidual homoeostasis in obstetric antiphospholipid syndrome
Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways. View Full Text Read the full text or download the PDF:
Multi-Scale Semantic Fusion of a Large Receptive Field for Irregular Pelvic X-Ray Landmark Detection
Loading [MathJax]/jax/output/HTML-CSS/autoload/mtable.js Accurate and reliable detection of anatomical landmarks is a crucial preprocessing step for therapy planning and intervention in various medical scenarios [1], including knee joint surgery [2], bone age estimation [3], carotid artery bifurcation [4], and vertebral trauma surgery [5]. Also, it plays an important role in medical image analysis, such as the initialization of registration [6] or segmentation algorithms [7].
Pumping‐induced Well Hydraulics and Groundwater Budget in a Leaky Aquifer System with Vertical Heterogeneity in Aquitard Hydraulic Properties
References , , and , 2020. Impact of layered heterogeneity on transient saltwater upconing in coastal aquifers. Journal of Hydrology, 581: 124393. , and , 2017. How does layered heterogeneity affect the ability of subsurface dams to clean up coastal aquifers contaminated with seawater intrusion? Journal of Hydrology, 553: 708–721. , and , 2019. Performance of low-enthalpy geothermal systems: Interplay of spatially correlated heterogeneity and well-doublet spacings. Applied Energy, 253: 113569.
Single-cell transcriptome analysis and protein profiling reveal broad immune system activation in IgG4-related disease
Resource and Technical AdvanceInflammation Open Access | 10.1172/jci.insight.167602 JCI Insight. https://doi.org/10.1172/jci.insight.167602. Copyright © 2023, Lu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract IgG4-related disease (IgG4-RD) is a systemic autoimmune disease with unclear pathogenesis.
Casein Kinase 1α as a Novel Factor Affects Thyrotropin Synthesis via PKC/ERK/CREB Signaling
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Analyzing the mechanism by which oyster peptides target IL-2 in melanoma cell apoptosis based on RNA-seq and m6A-seq
Analyzing the mechanism by which oyster peptides target IL-2 in melanoma cell apoptosis based on RNA-seq and m6A-seq Jiaojiao Han, Lingxin Geng, Chenyang Lu, Jun Zhou, Ye Li, Tinghong Ming, Zhen Zhang and Xiurong Su Abstract Melanoma is a kind of skin cancer with high malignancy and strong proliferation and invasion abilities. Chemotherapy drugs in the clinic have the disadvantages of high price and high toxicity.
An efficient NiCu@C/Al2O3 catalyst for selective hydrogenation of acetylene
An efficient NiCu@C/Al2O3 catalyst for selective hydrogenation of acetylene Shihong Zhou, Chenyang Lu, Wenyu Zhou, Yi Bi, Cailong Zhou, Aonan Zeng, Anjie Wang, Luxi Tan and Lichun Dong Abstract The development of non-noble metal catalysts for selective hydrogenation still remains a challenge.
Clinical significance of T cell receptor repertoire in primary Sjogren's syndrome
Summary Background Primary Sjogren's syndrome (SS) is a chronic inflammatory disease with unknown aetiology. Although clonal expansion of autoreactive T cells has been identified in patients with SS, the clinical correlation of T-cell receptor (TCR) variance in SS remains unclear. Methods TCRβ repertoire sequencing was performed on 260 SS patients with 3-6 months of follow-up in a cohort study to dynamically assess the characteristics of TCR diversity and their clinical significance.
Continuous real-time prediction of surgical case duration using a modular artificial neural network
Abstract Background Real-time prediction of surgical duration can inform perioperative decisions and reduce surgical costs. We developed a machine learning approach that continuously incorporates preoperative and intraoperative information for forecasting surgical duration. Methods Preoperative (e.g. procedure name) and intraoperative (e.g. medications and vital signs) variables were retrieved from anaesthetic records of surgeries performed between March 1, 2019 and October 31, 2019.
Correction: The gut microbiota mediates the protective effects of anserine supplementation on hyperuricaemia and associated renal inflammation
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The gut microbiota mediates the protective effects of anserine supplementation on hyperuricaemia and associated renal inflammation
The gut microbiota mediates the protective effects of anserine supplementation on hyperuricaemia and associated renal inflammation† Jiaojiao Han, ab Ziyan Wang,ab Chenyang Lu, ab Jun Zhou,ab Ye Li, ab Tinghong Ming,ab Zhen Zhang,ab Zaijie Jim Wangc and Xiurong Su *ab Author affiliations * Corresponding authors a State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, China E-mail: hanjiaojiao@nbu.edu.cn Fax: +86 574...
Gut microbiota mediated the protective effects of tuna oil on collagen-induced arthritis in mice
Gut microbiota mediated the protective effects of tuna oil on collagen-induced arthritis in mice Rheumatoid arthritis is emerging as a chronic autoimmune disease worldwide. In this study, the components of tuna oil (TO) were firstly measured, and the beneficial effects of TO on collagen-induced arthritis (CIA) mice were subsequently investigated.
The Novel Zoonotic Pathogen, Anaplasma capra, Infects Human Erythrocytes, HL-60, and TF-1 Cells In Vitro
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Performance of Risk Models for Antimicrobial Resistance in Adult Patients With Sepsis
Key Points Question Do patient case mix and local resistance rates affect the performance of antimicrobial resistance risk stratification models in community-onset and hospital-onset sepsis? Findings This retrospective cohort study of 39 893 adult patients with sepsis included 4.8% infections caused by ceftriaxone-resistant gram-negative bacilli (GNB) and 2.8% caused by cefepime-resistant GNB.
Role of immunosuppressive therapy in rheumatic diseases concurrent with COVID-19
Role of immunosuppressive therapy in rheumatic diseases concurrent with COVID-19 Free http://orcid.org/0000-0002-5385-7708Chenyang Lu1, Shasha Li2, Yi Liu1 1 Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, China 2 Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA Correspondence to Professor Yi Liu, rheumatology and immunology, Sichuan University West China Hospital, Chengdu, Sichuan, China;...
Role of immunosuppressive therapy in rheumatic diseases concurrent with covid-19
Role of immunosuppressive therapy in rheumatic diseases concurrent with covid-19 Free http://orcid.org/0000-0002-5385-7708Chenyang Lu1, Shasha Li2, Yi Liu1 1Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, China 2Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA Correspondence to Professor Yi Liu, rheumatology and immunology, Sichuan University West China Hospital, Chengdu, Sichuan, China;...
CD13/Aminopeptidase N Is a Potential Therapeutic Target for Inflammatory Disorders
Chenyang Lu, Mohammad A. Amin and David A. Fox J Immunol January 1, 2020, 204 (1) 3-11; DOI: https://doi.org/10.4049/jimmunol.1900868 Abstract CD13/aminopeptidase N is a widely expressed ectoenzyme with multiple functions. As an enzyme, CD13 regulates activities of numerous cytokines by cleaving their N-terminals and is involved in Ag processing by trimming the peptides bound to MHC class II.
Angiogenic and Arthritogenic Properties of the Soluble Form of CD13
Yuxuan Du, Chenyang Lu, Rachel L. Morgan, William A. Stinson, Phillip L. Campbell, Ellen Cealey, Wenyi Fu, Nicholas J. Lepore, Jonatan L. Hervoso, Huadong Cui, Andrew G. Urquhart, Jeffrey N. Lawton, Kevin C. Chung, David A. Fox and Mohammad A. Amin J Immunol July 15, 2019, 203 (2) 360-369; DOI: https://doi.org/10.4049/jimmunol.1801276 Key Points Soluble CD13 (sCD13) is a potent angiogenic factor in vitro and in vivo. sCD13 induces acute inflammatory arthritis in mice and induces MN migration via GPCR.
Angiogenic and Arthritogenic Properties of the Soluble Form of CD13
Yuxuan Du, Chenyang Lu, Rachel L. Morgan, William A. Stinson, Phillip L. Campbell, Ellen Cealey, Wenyi Fu, Nicholas J. Lepore, Jonatan L. Hervoso, Huadong Cui, Andrew G. Urquhart, Jeffrey N. Lawton, Kevin C. Chung, David A. Fox and Mohammad A. Amin J Immunol June 12, 2019, ji1801276; DOI: https://doi.org/10.4049/jimmunol.1801276 Key Points Soluble CD13 (sCD13) is a potent angiogenic factor in vitro and in vivo. sCD13 induces acute inflammatory arthritis in mice and induces MN migration via GPCR.
Disorder in Mn+1AXn phases at the atomic scale
Abstract Atomic disordering in materials alters their physical and chemical properties and can subsequently affect their performance. In complex ceramic materials, it is a challenge to understand the nature of structural disordering, due to the difficulty of direct, atomic-scale experimental observations.
Shockwave generates < 100 > dislocation loops in bcc iron
Punch-out procedure We investigate the displacement cascades in pure bcc iron via molecular dynamics simulations at a temperature of 300 K. The high Primary Knock-on Atom (PKA) recoil energy EPKA of 100, 150, and 200 keV are modelled within large simulation boxes containing 16,000,000 and 221,184,000 atoms. The high energy particle starts in the <351> direction from the left side of the simulation box at time zero.
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