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Christian M. Metallo on Muck Rack

Christian M. Metallo

As seen in: Nature, ScienceDirect, ACS Publications, Cell Metabolism, Cell Press, Cell Reports, Annual Reviews Journal, The Journal of Clinical Investigation, Drug Discovery World
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Articles

A genome-scale CRISPRi perturbation atlas of human induced pluripotent stem cells

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By Sami Nourreddine, Yesh Doctor, Amir Dailamy, Jan N. Hansen, Antoine Forget, Benjamin J. Polacco, Monita Muralidharan, Alina Sigaeva, Emily Pan, Jiahao Gao, Jake Chen, Timothy D. Clark, Jillian Parker, Kirsten Obernier, Christian M. Metallo, Trey Ideker, Emma Lundberg, Nevan J. Krogan, Prashant Mali, Yi-Hung Lee, Rebecca Chinn, Sushant Sunder
| Nature Verified
Abstract Comprehensively mapping the relationship between genotype and phenotype offers essential insights into how a cell’s state arises from its genetic components. Toward this goal, we generated an expressed genome-scale CRISPRi perturbation cell atlas in KOLF2.1J human induced pluripotent stem cells, mapping transcriptional phenotypes associated with 11,692 perturbed genes across >2.5 million single cells.
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Modeling lipid homeostasis using stable isotope tracing and flux analysis

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By Karl A. Wessendorf-Rodriguez, Maureen L. Ruchhoeft, Christopher Murray, Yale Huang, Ethan Ashley, Hector Galvez, Grace McGregor, Shrikaar Kambhampati, Reuben J Shaw, Christian M. Metallo
| Cell Metabolism Verified
Keywords lipid homeostasis LKB1 TP53 metabolic flux analysis sphingolipids non-small cell lung cancer precision-cut lung slice culture ELOVL1 very long-chain fatty acids ceramide Introduction Lipids are the most abundant and diverse group of metabolites in cells and tissues.
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p53 increases phospholipid headgroup scavenging in senescence - Nature Cell Biology

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By Katrina Paras, Benjamin Jackson, Richard P. Koche, Christian M. Metallo
| Nature Verified
Abstract Changes in cell state are often accompanied by altered metabolic demands, and homeostasis depends on cells adapting to their changing needs. One major cell state change is senescence, which is associated with dramatic changes in cell metabolism, including increases in lipid metabolism, but how cells accommodate such alterations is poorly understood.
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