Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Cong Jiang
G-protein-coupled receptor sensing of farnesol controls fungal dormancy and is susceptible to bacterial interference
Abstract Conidial dormancy is a critical survival strategy for fungi under stress, yet the mechanisms governing the switch between dormancy and germination remain unclear. Here we identify the G-protein-coupled receptor, Rsd1, as a farnesol-responsive sensor controlling this dormancy switch in the plant pathogen Fusarium pseudograminearum, which causes Fusarium crown rot.
Organic Nanozyme-Embedded Biotherapeutic Thermosensitive Hydrogel for Extracellular GSH Depletion and Postoperative Tumor Suppression
1 Introduction Glutathione (GSH), a tripeptide composed of cysteine, glutamic acid, and glycine, is traditionally recognized as a key intracellular antioxidant, but accumulating evidence has revealed that extracellular GSH in the tumor microenvironment (TME) plays an irreplaceable role in tumor metabolism and recurrence [1-4].
Retraction Note: Human HDAC6 senses valine abundancy to regulate DNA damage
Retraction to: Nature https://doi.org/10.1038/s41586-024-08248-5 Published online 20 November 2024 The Editors have retracted this article. After publication, concerns were raised regarding the authenticity of the numerical source data for Fig. 4c,f and Extended Data Figs. 5c,f and 6c,m, which report results for the quantification of γH2AX-positive cells under different experimental conditions. These datasets show unusual similarities within and between figure panels.
Rapid analysis of coal ash composition and ash fusion temperatures using laser-induced breakdown spectroscopy
Abstract Conventional methods for coal ash composition analysis and ash fusion temperature (AFTs) determination are time-consuming, costly, and prone to subjective biases, precluding their use in real-time industrial scenarios. To address the aforementioned problems, this paper proposes a rapid analysis method for coal ash composition and ash fusion temperatures (AFTs) based on laser-induced breakdown spectroscopy (LIBS).
Author Correction: Epitranscriptomic RNA editing resolves Mus81 DNA repair tradeoffs in heat tolerance and meiosis
Correction to: Nature Communications https://doi.org/10.1038/s41467-026-71219-z, published online 30 March 2026 In the version of this article initially published, the image shown for FgMUS81PE in Fig. 2c was an inadvertent duplicate of Fig. 2c WT. The Figure 2c source data, and, for comparison, the originally published Fig. 2, are available as Supplementary Information alongside this amendment. The figure has been updated in the HTML and PDF versions of the article.
A positive phase of the winter North Atlantic oscillation is associated with drought in Central Europe the following summer
Abstract More frequent and severe droughts in Central Europe threaten water security and ecosystem resilience. The winter North Atlantic Oscillation (NAO), which regulates much of Europe’s hydroclimate, increasingly drives summer drought propagation across the region.
Adaptive Spo11 RNA editing gate optimizes meiosis I pace and mitotic proliferation while preserving ascospore formation
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Spo11-mediated DNA double-strand breaks (DSBs) are essential for meiotic recombination, yet how Spo11 activity is temporally regulated during mitosis and fungal development remains unclear.
Event-scale ecological impacts of dust storms in East Asia: processes, damage, and assessment challenges
Abstract Dust storms can cause rapid ecological impacts on terrestrial and marine ecosystems. This review synthesizes the event-scale ecological impacts of East Asian dust storms, focusing on dust generation, transport, deposition, and ecosystem responses. It further evaluates the strengths and limitations of current observational and modeling approaches for capturing the immediacy and destructiveness of dust storms.
Free-space twin-field quantum key distribution
Abstract Twin-field quantum key distribution elevates the secure key rate from a linear to a square-root dependence on channel loss and preserves the measurement-device-independent security. This protocol is uniquely positioned to enable global-scale quantum networks, even under extreme channel loss.
Aberrant amino acid-sensing promotes immunotherapy resistance via the inflammatory cytokine–ZBTB5–mTORC1 axis
|
Abstract Acute activation of mTORC1 by amino acids (AAs) is pivotal for growth regulation, yet it remains unclear how the intracellular nutrient-sensing machinery might be rewired by environmental cues to execute distinct functions. Here we report that, despite nutrient insufficiency, cancer-intrinsic AA-sensing mTORC1 signalling is hijacked by inflammatory cytokines in the tumour microenvironment (TME).
By Junyu Xiang, Tao Wang, Jinyang Li, Mengyun Luo, Yuzhu Wang, Aibei Du, Xu Chen, Lei Wang, Yongchao Zhang, Mengyi Han, Wenqing Hou, Xinyu Wang, Tao Hou, Qin Liu, Dongfeng Chen, Zhongyi Qin, Xianfeng Li, Cong Jiang, Qiaoqiao Zhang, Pengda Liu, Xiuwu Bian, Wenyi Wei, Bin Wang, Shuoran Tian, Fanxuan Tian, Liangzhi Wen
|
Nature
Verified
Epitranscriptomic RNA editing resolves Mus81 DNA repair tradeoffs in heat tolerance and meiosis
Abstract Maintaining genome integrity is essential, yet how DNA repair is balanced across life stages remains poorly understood. Here we uncover an epitranscriptomic mechanism in the fungal pathogen Fusarium graminearum that alleviates a trade-off between heat-stress adaptation and sexual reproduction.
Compartmentalised Function of TaHRC‐R Orchestrates ROS Production and Nuclear Condensate Dynamics
Fusarium head blight (FHB), mainly caused by Fusarium graminearum, poses a serious threat to wheat production worldwide and ranks among the most devastating crop diseases. In addition to causing significant yield losses, F. graminearum also produces deoxynivalenol (DON), the most commonly detected mycotoxin in cereal grains, raising major food and feed safety concerns (Son et al. 2011).
Regulation of Single and Multiple Genes in Bacillus amyloliquefaciens by an Evolution System In Vivo
Abstract Click to copy section linkSection link copied! With the development of synthetic biology, an evolution system in vivo has been applied to accelerate the construction of cell factories. In this study, an efficient in vivo evolution system was developed for regulation of single and multiple genes in Bacillus amyloliquefaciens.
Potential biases in test-negative design studies of COVID-19 vaccine effectiveness arising from the inclusion of asymptomatic individuals
Ayuda Buscar en la ayuda Buscar en la ayuda Potential biases in test-negative design studies of COVID-19 vaccine effectiveness arising from the inclusion of asymptomatic individuals Ortiz-Brizuela, Edgar [1] ; Carabali, Mabel [1] ; Jiang, Cong [2] ; Merckx, Joanna [1] ; Talbot, Denis [3] ; Schnitzer, Mireille E [2] [1] Department of Epidemiology, Biostatistics, and Occupational Health, McGill University , Montréal, Québec H3A 1G1 , [2] Faculty of Pharmacy, Université de Montréal , Montréal,...
Multi-omics investigation of spontaneous T2DM macaque emphasizes gut microbiota could up-regulate the absorption of excess palmitic acid in the T2DM progression
eLife Assessment This important work substantially advances our understanding of the interaction among gut microbiota, lipid metabolism, and the host in type 2 diabetes. The evidence supporting the claims of the authors is convincing. The work will be of interest to medical biologists working on microbiota and diabetes.
The Molecular Basis of Amino Acids Sensing
Threonine Sensor of mTORC1 Signaling Mitochondrial threonyl-tRNA synthetase 2 (TARS2) has been suggested to act as a threonine sensor for mTORC1 signaling.
A Model for Regional‐Scale Water Erosion and Sediment Transport and Its Application to the Yellow River Basin
1 Introduction Understanding the dynamics of water erosion and sediment transport is crucial across multiple disciplines, including agriculture (Montgomery, 2007; Syvitski et al., 2005), hydraulic and sedimentation engineering (Rijn, 1986; Vanoni, 2006), hydrology (Fagundes et al., 2021; Gao et al., 2013), ecology (Newbold et al., 2015; Oost et al., 2007), and geomorphology (Dietrich et al., 2003; Tucker & Hancock, 2010).
Copper‐Doped Polydopamine Nanoparticles‐Mediated GSH/GPX4‐Depleted Ferroptosis and Cuproptosis Sensitizes Lung Tumor to Checkpoint Blockade Immunotherapy
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202503208-sup-0001-SuppMat.docx10.7 MB Supporting Information References 1, , , , , , , CA: A Cancer J. Clin. 2021, 71, 209. 2, , , , , , , , , , , , , Clin. Cancer Res. 2018, 24, 2148. 3, , , , Proc. Natl. Acad. Sci. USA 2020, 117, 28922. 4, , , , , , , , , , , , , , , , , , , J. Clin. Oncol. 2015, 33, 15. 5, , , , , , J. Clin. Oncol. 2020, 38, 15. 6, , , Cancer Discov 2018, 8, 1069.
Karst Tiankeng Is the Refuge of Microbial Diversity in the Degraded Karst Landscape
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description ldr5582-sup-0001-Supinfo.docxWord 2007 document , 922 KB Data S1. Supporting Information. References , , , et al. 2020. “Topoclimates, Refugia, and Biotic Responses to Climate Change.” Frontiers in Ecology and the Environment 18, no. 5: 288–296. https://doi.org/10.1002/fee.2204. , , , et al. 2018. “Structure and Function of the Global Topsoil Microbiome.” Nature 560, no. 7717: 233–237.
A Double Machine Learning Approach for the Evaluation of COVID‐19 Vaccine Effectiveness Under the Test‐Negative Design: Analysis of Québec Administrative Data
In the context of TND sampling, to develop an efficient and doubly robust VE estimator that can integrate machine learning methods, we start by deriving the efficient influence function (EIF) for ψ v $$ {\psi}_v $$ using the Gateaux derivative [29]. We then study the second-order remainder term of the von Mises expansion for ψ v $$ {\psi}_v $$ .
A Double Machine Learning Approach for the Evaluation of COVID-19 Vaccine Effectiveness under the Test-Negative Design: Analysis of Quebec Administrative Data
The authors have declared no competing interest. The authors gratefully acknowledge a Canadian Institutes of Health Research Project Grant, and CJ is grateful for the postdoctoral fellowship awarded by the StatLab at the Centre de Recherches Mathematiques. DT is supported by a research-career award from the Fonds de recherche du Quebec -- Sante. MES holds a Canada Research Chair in Causal Inference and Machine Learning in Health Science.
Associations between Life’s Essential 8 and gallstones among US adults: A cross-sectional study from NHANES 2017-2018
Loading metrics Open Access Peer-reviewed Research Article Citation: Wang T, Xie R, Jiang C, Chen L (2024) Associations between Life’s Essential 8 and gallstones among US adults: A cross-sectional study from NHANES 2017–2018. PLoS ONE 19(10): e0312857.
Multi-omics investigation of spontaneous T2DM macaque reveals gut microbiota promote T2DM by up-regulating the absorption of excess palmitic acid
Abstract Although gut microbiota and lipid metabolites have been suggested to be closely associated with type 2 diabetes mellitus (T2DM), the interactions between gut microbiota, lipid metabolites and the host in T2DM development remains unclear. Rhesus macaques may be the best animal model to investigate these relationships given their spontaneous development of T2DM.
Research on Mechanical Performance of In-Service Continuous Rigid-Frame Bridge Based on Vehicle-Bridge Coupling Vibration
1. Introduction With the continuous development of the highway transportation industry, the number of highway bridges is steadily increasing. The continuous rigid-frame bridge has large longitudinal and transverse stiffness and remarkable mechanical performance and span capacity.
Digital Twin-Enhanced Control for Fuel Cell and Lithium-Ion Battery Hybrid Vehicles
1. Introduction 1.1. Background and Motivation New energy vehicles are receiving more and more attention because of their environmental friendliness and high efficiency. In recent years, automobile companies such as Honda and Mercedes-Benz have begun to focus on the development of electric vehicle technologies [1]. Battery Electric Vehicles (BEVs) are suitable for short distances [2].
Twin-Field Quantum Key Distribution with Local Frequency Reference
Twin-field quantum key distribution (TFQKD) overcomes the linear rate-loss limit, which promises a boost of secure key rate over long distance. However, the complexity of eliminating the frequency differences between the independent laser sources hinders its practical application. We analyzed and determined the frequency stability requirements for implementing TFQKD using frequency-stabilized lasers.
Identification of a Novel Chitinase from Bacillus paralicheniformis: Gene Mining, Sequence Analysis, and Enzymatic Characterization
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Estimating dynamic treatment regimes for ordinal outcomes with household interference: Application in household smoking cessation
1. Introduction Precision medicine, also known as personalized medicine, refers to treating patients according to their unique characteristics. Dynamic treatment regimes (DTRs), as a statistical framework for precision medicine, provide individualized treatment recommendations based on patients’ individual information.
Side-channel security of practical quantum key distribution
We present general security proof for quantum key distribution (QKD) with imperfect states in whole space including both the operational space and the other space (side-channel space). We show that in a protocol where Alice (Bob) uses two states, the secure key rate for a real protocol using imperfect (mixed) states is the same as that of a perfect protocol if the real protocol can be mapped from the perfect protocol.
Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis
Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial damage, but its underlying mechanism and functional consequences are largely unknown.
Expression of Ice Nucleation Protein in Bacillus amyloliquefaciens and Its Application in Food Freezing Process
1. Introduction In the field of cloud physics, the process of ice nucleation assumes pivotal significance, as it holds extensive implications not only in the realm of biology, medicine, and food processing but also in various other disciplines [1]. In the absence of ice nucleating particles, the formation of ice in the atmosphere is limited to temperatures as low as −38 degrees [2].
CuCeTA nanoflower as an efficient peroxidase candidate for directly colorimetric detection of glyphosate
CuCeTA nanoflower as an efficient peroxidase candidate for directly colorimetric detection of glyphosate Conventional nanozyme-based pesticide detection often requires the assistance of acetylcholinesterase. In this work, CuCeTA nanozyme was successfully designed for intelligent detection of glyphosate directly. By assembling tannic acid, cooper sulfate pentahydrate and cerium (III) nitrate hexahydrate, CuCeTA nanoflower was prepared.
Free-Space and Fiber-Integrated Measurement-Device-Independent Quantum Key Distribution under High Background Noise
Abstract Measurement-device-independent quantum key distribution (MDI QKD) provides immunity against all attacks targeting measurement devices. It is essential to implement MDI QKD in the future global-scale quantum communication network. Toward this goal, we demonstrate a robust MDI QKD fully covering daytime, overcoming the high background noise that prevents BB84 protocol even when using a perfect single-photon source.
HAT-Mediated Electrochemical C(sp2)-H Acylation of Quinolines with Alcohols
Herein, an electrochemical hydrogen atom transfer (HAT) strategy for C(sp2)–H formylation of electron-deficient quinolines and isoquinolines is described. The cheap methanol acts as a formyl source with a catalytic amount of N-hydroxyphthalimide (NHPI) as the hydrogen atom transfer (HAT) catalyst.
Side-Channel-Secure Quantum Key Distribution with Imperfect Vacuum Sources
Abstract The side-channel-secure (SCS) quantum key distribution (QKD), SCS QKD has attracted much attention due to its higher security compared to the measurement-device-independent protocols. It is not only measurement-device-independent secure, but also secure against source-state side channels provided that Eve has no access to Alice’s or Bob’s setups inside their labs.
Ferroptosis and Pyroptosis Co‐Activated Nanomodulator for “Cold” Tumor Immunotherapy and Lung Metastasis Inhibition
Abstract Immune checkpoint blockade (ICB) therapy is an emerging strategy for cancer immunotherapy; however, the actual effects of ICB therapy are greatly limited by the immunosuppressive tumor microenvironment (TME, i.e., “cold” tumors). Although engineered nanomaterials display significant importance to regulate TME in cancer treatment, most of them focus on “immunosilent” apoptotic processes that cannot elicit sufficient immune responses for further immunotherapy.
Experimental Twin-Field Quantum Key Distribution over 1000 km Fiber Distance
Abstract Quantum key distribution (QKD) aims to generate secure private keys shared by two remote parties. With its security being protected by principles of quantum mechanics, some technology challenges remain towards practical application of QKD. The major one is the distance limit, which is caused by the fact that a quantum signal cannot be amplified while the channel loss is exponential with the distance for photon transmission in optical fiber.
Enzymatic enrichment of acylglycerols rich in n − 3 polyunsaturated fatty acids by selective methanolysis: Optimization and kinetic studies
Abstract n − 3 Polyunsaturated fatty acids (n − 3 PUFA) have special physiological effect, but their contents in natural oils may not meet the growing demand. Lipase-catalyzed selective methanolysis could be used to produce acylglycerols rich in n − 3 PUFA.
Sending-or-not-sending twin-field quantum key distribution with redundant space
We propose to adopt redundant space such as polarization mode in the sending-or-not-sending twin-field quantum key distribution (TF-QKD) in the Fock space. With the help of redundant space such as photon polarization, we can postselect events according to the outcome of the observation to the additional quantity. This compresses the bit-flip error rate in the postselected events of the SNS protocol.
Electrochemical Silylation of Electron‐Deficient Heterocycles Using N‐Hydroxyphthalimide as HAT Catalyst
Abstract A practical electrochemical Minisci-type reaction for the synthesis of silylated heterocycles is described. Using N-hydroxyphthalimide (NHPI) as the hydrogen atom transfer (HAT) catalyst and trialkylsilanes as the silyl radical sources, a wide range of electron-deficient heterocycles in-cluding quinoline, quinoxaline, phthalazine, 3,6-dichloropyridazine, phenanthridine, 6-chloroimidazo[1,2-b]pyridazine and coumarin, etc.
High-power diode-end-pumped 1314 nm laser based on the multi-segmented Nd:YLF crystal
Abstract We demonstrate the first multi-segmented Nd:YLF laser, to the best of our knowledge. The multi-segmented crystal was designed to straightforwardly aim for the minimum thermal stress without sacrificing the overall laser efficiency, with the influence of the pump beam waist position considered in particular.
Flood Frequency Analysis Using Mixture Distributions in Light of Prior Flood Type Classification in Norway
Open AccessArticle by Lei Yan 1,2,3,*, Liying Zhang 4, Lihua Xiong 1, Pengtao Yan 5, Cong Jiang 6, Wentao Xu 7, Bin Xiong 8, Kunxia Yu 9, Qiumei Ma 10 and Chong-Yu Xu 11 1 State Key Laboratory of Water Resources and Hydropower Engineering Science, Wuhan University, Wuhan 430072, China 2 College of Water Conservancy and Hydropower, Hebei University of Engineering, Handan 056021, China 3 Hebei Key Laboratory of Intelligent Water Conservancy, Hebei University of Engineering, Handan 056038, China...
Numerical Study on the Progressive Damage Behavior of the Interfacial Debonding between Shape Memory Alloy and Polymer Matrix
Open AccessArticle by Hao Li 1, Cong Jiang 1, Zhaogang Yu 1, Yun Wan 1,*, Yunsheng Ma 2,* and Zhaoyang Yang 2 1 School of Civil Engineering and Architecture, East China Jiaotong University, Nanchang 330013, China 2 Shandong Chambroad Holding Group Co., Ltd., Binzhou 256500, China * Authors to whom correspondence should be addressed.
Ring domains are essential for GATOR2-dependent mTORC1 activation
Saxton R.A. Sabatini D.M. MTOR signaling in growth, metabolism, and disease. Cell. 2017; 168: 960-976https://doi.org/10.1016/j.cell.2017.02.004 mTOR at the nexus of nutrition, growth, ageing and disease. Nat. Rev. Mol. Cell Biol. 2020; 21: 183-203https://doi.org/10.1038/s41580-019-0199-y Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell Biol. 2009; 10: 307-318https://doi.org/10.1038/nrm2672 Mossmann D. Park S.
The recent development of nanozymes for targeting antibacterial, anticancer and antioxidant applications
The recent development of nanozymes for targeting antibacterial, anticancer and antioxidant applications Huimin Zhong,†a Cong Jiang†a and Yanyan Huang *a Abstract Nowadays, nanozymes have not only been used as biosensors in the detection field, but also their application prospects in disease treatment have been explored.
Electrochemical Minisci reaction via HAT-driven α-C(sp3)−H functionalization of alcohols
Electrochemical Minisci reaction via HAT-driven α-C(sp3)−H functionalization of alcohols Heng Li, Jinwen Tong, Yan Zhu, Cong Jiang, Ping Liu and Peipei Sun Abstract An efficient electrochemical Minisci reaction to access 3-hydroxyalkylquinoxalin-2(1H)-ones involved hydrogen atom transfer (HAT) driven α-C(sp3)−H functionalization of alcohols was achieved.
Power and energy scaling of an acousto-optically Q switched Raman deep-red laser
Abstract An efficient high-power nanosecond pulsed deep-red laser at 745 nm is produced by intracavity frequency-doubling an acousto-optically Q switched Nd:YLF/KGW Raman laser using a lithium triborate (LBO) crystal. The critically phase-matched type-I LBO crystal with an optimized length of 25 mm is adopted to enable efficient second-harmonic generation and to suppress unwanted cascaded Stokes fields.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Cong
Contact Cong, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack