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Cynthia E. Dunbar on Muck Rack

Cynthia E. Dunbar

As seen in: Nature, ScienceDirect, Science Magazine, Cell Reports, Cell Press, Healio, HemOnc Today
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Articles

Microglial clonal dynamics and the impact of clonal hematopoiesis in autologously transplanted rhesus macaques

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By Yifan Zhou, Diana Abraham, Taha Bartu Hayal, Ashley Gin, Xing Fan, Byung-Chul Lee, Taehoon Shin, Mario Roederer, George S. Vassiliou, Chuanfeng Wu, Cynthia E. Dunbar, Rohan V. Hosuru
| Cell Reports Verified
Keywords microglia rhesus macaques clonal hematopoiesis hematopoietic stem cell transplantation Research topic(s) CP: stem cell research CP: neuroscience Introduction Microglia are essential resident immune cells of the central nervous system (CNS).
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Kitlo hematopoietic stem cells exhibit distinct lymphoid-primed chromatin landscapes that enhance thymic reconstitution - Nature Communications

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By Harold K. Elias, Sneha Mitra, Brianna Gipson, Simon Grassmann, Rhoshini Raghuraman, Melody Smith, Roshan Sharma, Cynthia E. Dunbar, Christopher Park, Christina Leslie, Avinash Bhandoola, Michael G. Kharas
| Nature Verified
Abstract Hematopoietic stem cells (HSC) with multilineage potential are critical for T cell reconstitution after allogeneic hematopoietic cell transplantation (allo-HCT). The Kitlo HSC subset is enriched for multipotential precursors, but their T cell potential remains poorly characterized. Using a preclinical allo-HCT mouse model, we demonstrate that Kitlo HSCs provide superior thymic recovery and T cell reconstitution, resulting in improved immune responses to post-transplant infection.
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Bicistronic CAR-T effective for children with relapsed B-ALL

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By Josh Friedman, Mark Leiser Verified, Cynthia E. Dunbar
| HemOnc Today Verified
You've successfully added to your alerts. You will receive an email when new content is published. Click Here to Manage Email Alerts We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com. Key takeaways: Most children with relapsed or refractory B-lineage acute lymphoblastic leukemia achieved complete remission with bicistronic CAR-T. Nearly half of participants had grade 3 or 4 cytokine release syndrome.
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