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Articles by Daniel Schrimpf
Distinct molecular subgroups in pediatric and young-onset meningiomas require age-adapted risk stratification
Abstract Meningiomas in pediatric and adolescent/young adult patients are poorly characterized biologically and clinically, and risk stratification is largely extrapolated from adult tumors. We analyze 293 tumors from patients aged 0–39 years using integrated histopathological and molecular profiling.
Hetairos is a histology-based artificial intelligence model for predicting central nervous system tumor methylation subtypes
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Abstract Molecular testing is essential for classifying central nervous system (CNS) tumors, with methylation profiling providing the highest diagnostic granularity. However, this requires more resources and time than conventional hematoxylin and eosin (H&E) histopathology, which is widely available globally. Here we propose Hetairos, an artificial intelligence algorithm that predicts 102 methylation-based CNS tumor subtypes from digital H&E slides.
By Darui Jin, Artem Shmatko, Areeba Patel, Samuel Rutz, Lukas Friedrich, Rouzbeh Banan, Ramin Rahmanzade, Philipp Sievers, Stefan Hamelmann, Daniel Schrimpf, Kirsten Göbel, Sybren L. N. Maas, Martin Sill, Felix Hinz, Abigail K. Suwala, Felix Keller, Antje Habel, Gleb D. Rukhovich, Ferdinand Zettl, Obada T. Alhalabi, Sebastian Ille, Jannik Sehring, Daniel Amsel, Benedikt Wiestler, Pedro Lago, Bogdana Suchorska, Dominik Sturm, David E. Reuss, Pieter Wesseling, Frank L. Heppner, Ingmar Blümcke, Claire Delbridge, Martin Jakobs, Christel Herold-Mende, Sandro M. Krieg, Wolfgang Wick, David Jones, Stefan M. Pfister, Maysa Al-Hussaini, Yanghao Hou, Felipe D’Almeida Costa, Leonille Schweizer, Luca Bertero, Arnault Tauziède-Espariat, Pascale Varlet, Doron Merkler, Kristof Egervari, Hildegard Dohmen, Roger Gejman, Sebastian Brandner, Xiangzhi Bai, Andreas von Deimling, Felix Sahm, Moritz Gerstung, Henri Bogumil, Olfat Ahmad, Adelheid Wöhrer, Pablo Zoroquiain
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Nature
Verified
A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classification
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Oncologists Are Begging People To Take This One Common Cancer Risk Factor Seriously We’re not thinking or talking about this one enough. No one gets cancer on purpose. Yet, it’s hard to find someone who the disease hasn’t touched, …
By Yiheng Tang, Eric Y. Stutheit-Zhao, Ramin Rahmanzade, Christina Blume, Thomas Hielscher, Ferdinand Zettl, Salvatore Benfatto, Domenico Calafato, Martin Sill, Yahaya A. Yabo, Felix Behling, Abigail K. Suwala, Helin Kardo, Michael Ritter, Matthieu Peyre, Roman Sankowski, Konstantin Okonechnikov, Philipp Sievers, Areeba Patel, David E. Reuss, Mirco Friedrich, Damian Stichel, Daniel Schrimpf, Katja Beck, Hans-Georg Wirsching, Gerhard Jungwirth, C. Oliver Hanemann, Katrin Lamszus, Nima Etminan, Andreas W. Unterberg, Christian Mawrin, Olivier Ayrault, Peter Lichter, Guido Reifenberger, Michael Platten, Tim Kacprowski, Markus List, Josch K. Pauling, Jan Baumbach, Zvi Ram, Miriam Ratliff, Jan-Philipp Mallm, Marian C. Neidert, Eelke M Bos, Marco Prinz, Michael Weller, Felix J. Hartmann, Matthias Preusser, Ghazaleh Tabatabai, Christel Herold-Mende, Sandro M. Krieg, Stefan M. Pfister, Wolfgang Wick, Michel Kalamarides, Andreas von Deimling, Dieter Henrik Heiland, Volker Hovestadt, Moritz Gerstung, Matthias Schlesner, Felix Sahm, Jasim Kada Benotmane, Rachel Grossmann
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Flipboard
Advancing CNS tumor diagnostics with expanded DNA methylation-based classification
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ArticleOnline nowOpen access 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany 2Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany 3Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany 4Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany 5Division of Pediatric...
By Martin Sill, Daniel Schrimpf, Areeba Patel, Dominik Sturm, Natalie Jäger, Philipp Sievers, Leonille Schweizer, Rouzbeh Banan, David E. Reuss, Abigail K. Suwala, Andrey Korshunov, Damian Stichel, Annika K Wefers, Ann-Christin Hau, Henning Boldt, Patrick N. Harter, Zied Abdullaev, Jamal Benhamida, Daniel Teichmann, Arend Koch, Jürgen Hench, Stephan Frank, Martin Hasselblatt, Sheila Mansouri, Jonathan Serrano, Jonas Ecker, Michael Taylor Verified, Vijay Ramaswamy, Anna S. Berghoff, Brigitte Bison, Mirjam Blattner-Johnson, Ivo Buchhalter, Gabriele Calaminus, Nicola Dikow, Hildegard Dohmen, Philipp Euskirchen, Gudrun Fleischhack, Amar Gajjar, Nicolas U. Gerber, Marco Gessi, Gerrit H. Gielen, Astrid K. Gnekow, Nicholas G Gottardo, Christine Haberler, Stefan Hamelmann, Jordan Hansford, Christian Hartmann, Frank L. Heppner, Pablo Hernáiz Driever, Katja von Hoff, Ulrich W. Thomale, Michael C. Frühwald, Christof M. Kramm, Ulrich Schüller, Jens Schittenhelm, Martin Schuhmann, Marco Stein, Petra Ketteler, Marc Ladanyi, Nada Jabado, Barbara Jones, Chris Jones, Matthias A. Karajannis, Uwe Kordes, Annekathrin Reinhardt, Christian Kölsche, Katrin Lamszus, Peter Lichter, Sybren L.N. Maas, Christian Mawrin, Michel Mittelbronn, Camelia-Maria Monoranu, Wolf Mueller, Martin Mynarek, Paul A. Northcott, Kristian W. Pajtler, Werner Paulus, Arie Perry, Ingmar Blümcke, Karl H. Plate, Michael Platten, Matthias Preusser, Torsten Pietsch, Marco Prinz, Guido Reifenberger, Bjarne W. Kristensen, Marcel Kool, Volker Hovestadt, David Ellison, Thomas Jacques, Pascale Varlet, Nima Etminan, Michael Weller, Christine White, Olaf Witt, Christel Herold-Mende, Jürgen Debus, Sandro M. Krieg, Wolfgang Wick, Matija Snuderl, Sebastian Brandner, Cynthia Hawkins, Craig M Horbinski, Christian Thomas, Pieter Wesseling, Andreas von Deimling, David Capper, Stefan M. Pfister, Felix Sahm, Florian Selt, Rolf Buslei, Volkmar Hans, Stephan Tippelt, Ralf Ketter, Patricia Kohlhof, Ken Aldape
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Cell Press
Verified
Advancing CNS tumor diagnostics with expanded DNA methylation-based classification
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ArticleVolume 44, Issue 2p340-354.e2Open access 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany 2Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany 3Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany 4Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany...
By Martin Sill, Daniel Schrimpf, Areeba Patel, Dominik Sturm, Natalie Jäger, Philipp Sievers, Leonille Schweizer, Rouzbeh Banan, David E. Reuss, Abigail K. Suwala, Andrey Korshunov, Damian Stichel, Annika K Wefers, Ann-Christin Hau, Henning Boldt, Patrick N. Harter, Zied Abdullaev, Jamal Benhamida, Daniel Teichmann, Arend Koch, Jürgen Hench, Stephan Frank, Martin Hasselblatt, Sheila Mansouri, Jonathan Serrano, Jonas Ecker, Florian Selt, Michael Taylor Verified, Vijay Ramaswamy, Anna S. Berghoff, Brigitte Bison, Mirjam Blattner-Johnson, Ivo Buchhalter, Rolf Buslei, Gabriele Calaminus, Nicola Dikow, Hildegard Dohmen, Philipp Euskirchen, Gudrun Fleischhack, Amar Gajjar, Nicolas U. Gerber, Marco Gessi, Gerrit H. Gielen, Astrid K. Gnekow, Nicholas G Gottardo, Christine Haberler, Stefan Hamelmann, Volkmar Hans, Jordan Hansford, Christian Hartmann, Frank L. Heppner, Pablo Hernáiz Driever, Katja von Hoff, Ulrich W. Thomale, Stephan Tippelt, Michael C. Frühwald, Christof M. Kramm, Ulrich Schüller, Jens Schittenhelm, Martin Schuhmann, Marco Stein, Petra Ketteler, Marc Ladanyi, Nada Jabado, Barbara Jones, Chris Jones, Matthias A. Karajannis, Ralf Ketter, Patricia Kohlhof, Uwe Kordes, Annekathrin Reinhardt, Christian Kölsche, Katrin Lamszus, Peter Lichter, Sybren L.N. Maas, Christian Mawrin, Michel Mittelbronn, Camelia-Maria Monoranu, Wolf Mueller, Martin Mynarek, Paul A. Northcott, Kristian W. Pajtler, Werner Paulus, Arie Perry, Ingmar Blümcke, Karl H. Plate, Michael Platten, Matthias Preusser, Torsten Pietsch, Marco Prinz, Guido Reifenberger, Bjarne W. Kristensen, Marcel Kool, Volker Hovestadt, David Ellison, Thomas Jacques, Pascale Varlet, Nima Etminan, Michael Weller, Christine White, Olaf Witt, Christel Herold-Mende, Jürgen Debus, Sandro M. Krieg, Wolfgang Wick, Matija Snuderl, Ken Aldape, Sebastian Brandner, Cynthia Hawkins, Craig M Horbinski, Christian Thomas, Pieter Wesseling, Andreas von Deimling, David Capper, Stefan M. Pfister, Felix Sahm
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Cell Press
Verified
Advancing sarcoma diagnostics with expanded DNA methylation-based classification
PURPOSE: Sarcomas pose a severe diagnostic challenge. A wide variety of these distinct entities need to be distinguished from each other and from less aggressive types of mesenchymal tumors, to ensure correct clinical management. A machine learning based classifier for sarcomas utilizing DNA methylation data from 1077 tumors recognizing 62 sarcoma types has already been developed and termed the sarcoma classifier, which we published in 2021.
Anaplastic ganglioglioma-A diagnosis comprising several distinct tumour types
Key Points Molecular analyses and reassessment of histological features of tumours designated as anaplastic ganglioglioma revealed a wide spectrum of different entities. The majority of study cases could be assigned to established CNS WHO tumour types, whereas the non-assignable tumours were heterogeneous and did not constitute a distinct entity. Comprehensive molecular testing of cases with the histological designation of anaplastic ganglioglioma is recommended.
Sarcoma classification by DNA methylation profiling
Abstract External IDs PubMed 33479225
Accurate calling of KIAA1549‐BRAF fusions from DNA of human brain tumours using methylation array‐based copy number and gene panel sequencing data
ORIGINAL ARTICLE Damian Stichel Corresponding Author damian.stichel@med.uni-heidelberg.de Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany Correspondence Damian Stichel, Department of Neuropathology, Heidelberg University Hospital, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.
DNA methylation-based classification of central nervous system tumours
Hovestadt, V. et al. Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays . Acta Neuropathol. 125, 913–916 (2013) Weller, M. et al. Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups . Acta Neuropathol. 129, 679–693 (2015) Bady, P., Delorenzi, M. & Hegi, M. E.
DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis
Maintenance therapy with vinflunine plus best supportive care versus best supportive care alone in patients with advanced urothelial carcinoma with a response after first-line chemotherapy (MAJA; SOGUG 2011/02): a multicentre, randomised, controlled, open-label, phase 2 trial
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