David Burstein
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Articles by David Burstein
Single-cell atlas of transcriptomic vulnerability across brain disorders
Abstract Neurodegenerative and neuropsychiatric diseases impose a considerable societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited1,2.
Single-nucleus transcriptome-wide association study of human brain disorders
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Abstract Common brain disorders impose a substantial health burden, but localizing their genetic risk in the brain remains challenging1. Although genome-wide association studies have identified numerous loci associated with neuropsychiatric and neurodegenerative disorders, many of these loci lie in non-coding regions that influence gene expression in specific cell types2,3,4,5.
By Sanan Venkatesh, Roman Kosoy, Zhenyi Wu, Christian Dillard, Prashant N. M, David Burstein, Deepika Mathur, Chris Chatzinakos, Bukola Ajanaku, Fotis Tsetsos, Biao Zeng, Sonali Gupta Verified, Rachel Bercovitch, Aram Hong, Clara Casey, Marcela Alvia, Zhiping Shao, Stathis Argyriou, Karen Therrien, PsychAd Consortium, Tim B. Bigdeli, Pavan K. Auluck, David Bennett, Stefano Marenco, Vahram Haroutunian, Kiran Girdhar, Jaroslav Bendl, Donghoon Lee, John F. Fullard, Gabriel Hoffman, Georgios Voloudakis, Panos Roussos, Marios Anyfantakis
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Nature
Verified
Biological insights into schizophrenia from ancestrally diverse populations
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Abstract Schizophrenia and related psychoses occur in all human populations, with the highest rates of diagnosis among Black individuals and those of mainly African ancestry1. Decades of research have established a highly heritable and polygenic basis for schizophrenia, which is mostly shared across populations2,3,4. However, a recruitment bias towards European cohorts5 has led to discoveries that are poorly generalizable to African populations.
By Tim B. Bigdeli, Chris Chatzinakos, Jaroslav Bendl, Peter Barr, Sanan Venkatesh, Bryan R. Gorman, Tereza Clarence, Giulio Genovese, Conrad Iyegbe, Roseann E. Peterson, Sergios-Orestis Kolokotronis, David Burstein, Jacquelyn L. Meyers, Yuli Li, Sundar Natarajan, Michael Francis, Nallakkandi Rajeevan, Kei-Hoi Cheung, Lynn E. DeLisi, Thomas R. Kosten, Hongyu Zhao, Eric Achtyes, Peter Buckley, Dolores Malaspina, Douglas S Lehrer, Mark Rapaport, David L Braff, Michele Pato, Ayman H. Fanous, Carlos N. Pato, PsychAd Consortium, Grant D. Huang, Sumitra Muralidhar, J. Michael Gaziano, Saiju Pyarajan, Kiran Girdhar, Donghoon Lee, Gabriel Hoffman, Mihaela Aslan, John F. Fullard, Georgios Voloudakis, Philip Harvey, Panos Roussos
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Nature
Verified
Modeling diagnostic code dropout of schizophrenia in electronic health records improves phenotypic data quality and cross-ancestry transferability of polygenic scores
The authors have declared no competing interest. This research is based on data from the Million Veteran Program, Office of Research and Development, Veterans Health Administration, and was supported by awards #MVP076 (PR) and MVP#096 (DB). This publication does not represent the views of the Department of Veteran Affairs or the United States Government.
Using big sequencing data to identify chronic SARS-Coronavirus-2 infections - Nature Communications
Abstract The evolution of SARS-Coronavirus-2 (SARS-CoV-2) has been characterized by the periodic emergence of highly divergent variants. One leading hypothesis suggests these variants may have emerged during chronic infections of immunocompromised individuals, but limited data from these cases hinders comprehensive analyses. Here, we harnessed millions of SARS-CoV-2 genomes to identify potential chronic infections and used language models (LM) to infer chronic-associated mutations.
Using big sequencing data to identify chronic SARS-Coronavirus-2 infections
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A diverse repertoire of anti-defense systems is encoded in the leading region of plasmids
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Detecting and Adjusting for Hidden Biases due to Phenotype Misclassification in Genome-Wide Association Studies
Abstract With the advent of healthcare-based genotyped biobanks, genome-wide association studies (GWAS) leverage larger sample sizes, incorporate patients with diverse ancestries and introduce noisier phenotypic definitions. Yet the extent and impact of phenotypic misclassification on large-scale datasets is not currently well understood due to a lack of statistical methods to estimate relevant parameters from empirical data.
Dan Beckmann And Tom Hallaran’s Plan To Bring Big Data To Big Governme
After the inauguration of President Barack Obama, Dan Beckmann, a former Obama digital team strategist, stayed in D.C. to meet with Congressional staffers on both sides of the aisle. Beckmann, 32, had previously worked on developing and implementing new media strategy for ABC News and Current TV. Now, with all that he had learned about using technology on a political campaign, he was eager to try and use similar digital tools to increase the effectiveness in the governing process.
Google Marketing Exec Wael Ghonim And The Facebook Pag
A year ago–on January 25, 2011–a revolution broke out in Egypt. The world watched tens of thousands of protestors gathering in Tahrir Square demanding political and economic reforms and ultimately toppling longtime Egyptian leader Hosni Mubarak.
Tiny Hidden Genes within Our Microbiome
Exploration of tiny protein-coding sequences within the human microbiome reveals thousands of conserved gene families that have been overlooked by traditional analyses. These small proteins may play key roles in the crosstalk among bacteria within the microbiome and in interactions with their human hosts.
“How I Met Your Mother” Creators On Building A Long, Funny, Mystery
Craig Thomas and Carter Bays For seven seasons, the CBS sitcom How I Met Your Mother has kept viewers coming back, despite the show quite possibly breaking the record for the longest story ever told. That story resumed this week when the show’s eighth season premiered. For those who haven’t seen the show, or watched any sort of TV for the past seven years or interacted with popular culture in any way, it’s a sitcom about five friends reaching the end of their 20s.
A Functional Mini-Integrase in a Two-Protein-type V-C CRISPR System
Highlights • A mini-integrase comprising Cas1 alone catalyzes integration of short DNA fragments • V-C Cas1 has an intrinsic mechanism to orient protospacers during integration • Cas1 tetramerizes for integration, supporting a shortened internal ruler mechanism • Minimal integrase may represent the function of the ancestral Cas1 Summary CRISPR-Cas immunity requires integration of short, foreign DNA fragments into the host genome at the CRISPR locus, a site consisting of alternating repeat...
The Unlikely Multimedia Path Of Guardian Interactive Guru Gabriel Danc
As an undergraduate at Colorado State, Gabriel Dance majored in computer science. But he didn’t follow his peers into the technology sector. He chose to go into journalism, which in 2004 hadn’t even begun to seize opportunities in the digital space. Fast-forward to the fall of 2011.
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
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Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
Download and print this article for your personal scholarly, research, and educational use. Buy a single issue of Science for just $15 USD.
Novel Microbial Diversity and Functional Potential in the Marine Mammal Oral Microbiome
To use the Enhanced view of this article, please enable JavaScript on in your browser and refresh the page. Online Now Article ArticleNovel Microbial Diversity and Functional Potential in the Marine Mammal Oral Microbiome, Christine L. SunxChristine L.
The One Celebrity Who Could Beat The Rock to Take on Trump in 2020
Since their unimaginable (by most people, anyway) defeat on Election Day, one question above all has haunted Democrats: Who, besides Tom Hanks and The Rock, can beat Trump in 2020? Given Trump’s record-low approval rating and general inability to stop drawing attention to his own scandals and weaknesses, most Democrats assume he is weaker than ever. But Trump is pursuing the same strategy he pursued throughout the campaign: providing fuel to a hungry base to ensure their overwhelming turnout.
RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes
To use the Enhanced view of this article, please enable JavaScript on in your browser and refresh the page. ArticleRNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes, , , , Jennifer A. DoudnaxJennifer A.
The Generational Crisis in Politics Not Enough People Are Talking About
In an interview with NPR last week, Obama said he is “interested in developing a whole new generation of talent." The aftermath is shining a laser focused beam on the importance of developing a robust talent pipeline of leadership for our political ecosystem. CEOs across America will tell you that the most valuable resource in their company is human capital. Executives in fields as diverse as Hollywood, professional sports, non-profits, and school administration will echo that sentiment.
My Nightmare Trump Prediction Came True-Now What?
A little over a year ago, I wrote a piece for Vanity Fair outlining what seemed at the time like an improbably absurd argument—how Donald Trump, then a lunatic-fringe candidate with no political credibility, could somehow win the White House. His path to victory, I suggested, ran through traditionally Democratic strongholds such as Wisconsin, Pennsylvania, and Michigan, where I detected a unique hunger for an outsider.
Showtime's David Nevins On What It Takes To Make Sexy, Gripping TV
In the early '90s, most networks turned down the idea for the television show that would become ER. Not David Nevins. Nevins championed the show, and was instrumental in making the series—which turned George Clooney into a star—one of the biggest hits in TV history. Later, Nevins angled to get 24 on the air.
MRSA Causing Infections in Hospitals in Greater Metropolitan New York: Major Shift in the Dominant Clonal Type between 1996 and 2014
A surveillance study in 1996 identified the USA100 clone (ST5/SCCmecII)–also known as the “New York/Japan” clone—as the most prevalent MRSA causing infections in 12 New York City hospitals. Here we update the epidemiology of MRSA in seven of the same hospitals eighteen years later in 2013/14.
Lucky's Editor Eva Chen Wants To Build A Magazine You Can Talk To
"I love Times Square." Those might not be the words you would expect to hear out of the mouth of a fashion magazine editor, but this kind of statement is typical of Eva Chen, the new editor-in-chief of Lucky magazine. Since her arrival in June, now with two issues under her belt, she has been putting her own stamp on a magazine founded nearly a decade ago.
Here’s Why Donald Trump Really Could Be Elected President
From Brentwood mansions to Embassy Row in Washington, D.C., the idea that Donald Trump could become president has alternately set off fits of laughter and terror. While some political insiders, including a growing number of establishment Republicans, concede that Trump could win the nomination, few believe that Trump could actually become president.
Lucky’s Editor Eva Chen Wants To Build A Magazine You Can Talk To
“I love Times Square.” Those might not be the words you would expect to hear out of the mouth of a fashion magazine editor, but this kind of statement is typical of Eva Chen, the new editor-in-chief of Lucky magazine. Since her arrival in June, now with two issues under her belt, she has been putting her own stamp on a magazine founded nearly a decade ago.
Sun-2-24-5Broken Cameras, Health Freedom, BIL, Body of War-Fund Drive-1pmPT-90.7fm-kpfk.org
PODCAST: temcnally.podomatic.com - aworldthatjustmightwork.com - iTunes FREE FORUM with TERRENCE McNALLY Sunday Feb 24th --1-2pm PT (4-5pm ET) 90.7fm in LA, 98.7fm in Santa Barbara streaming at kpfk.org Emad Burnat, Guy Davidi, Jonathan Emord, Free Speech, FDA, and Nutritional Health Claims Paula Caplan, When Johnny & Jane Come Marching Home Fund Drive Show - Support Free Forum, KPFK 818-985-5735 / kpfk.org WBAI 99.5fm in NY Tuesday 10pm streaming at wbai.org terrencemcnally.net My new...
3 Storytelling Tips From "Breaking Bad" Creator Vince Gilligan
During our recent chat with Breaking Bad creator Vince Gilligan on subject of the fifth and final season of the show, he illuminated several storytelling principles that have helped make the series such a success. Here are a few of them. While strong characters are essential to any good story, rigidity when it comes to character development can be dangerous. Instead, Gilligan suggests writers allow themselves to get to know their characters over time.
3 Storytelling Tips From “Breaking Bad” Creator Vince Gilligan
During our recent chat with Breaking Bad creator Vince Gilligan on subject of the fifth and final season of the show, he illuminated several storytelling principles that have helped make the series such a success. Here are a few of them. While strong characters are essential to any good story, rigidity when it comes to character development can be dangerous. Instead, Gilligan suggests writers allow themselves to get to know their characters over time.
How Jeff Slobotski Turned The Midwest Into The Silicon Prairie
Traveling across America as a sales rep for Truist, a social responsibility-powering tech company, Jeff Slobotski regularly visited the country’s startup hubs. Slobotski, intrigued by his experiences, began chronicling his travels on a personal blog. But in 2008, he took another look his hometown of Omaha, Nebraska, and the surrounding Midwestern region. He was impressed by the burgeoning startup scene in his own backyard. “It is this incredible hidden gem,” Slobotski says with joy.
The New York Times’s Nick Kristof On Journalism In A Digital World And
Nicholas Kristof has been writing for The New York Times for more than a quarter century and has appeared on that paper’s op-ed page since 2001, often penning articles about the struggles of people in distant parts of the world. He has even been dubbed the “moral conscience” of his generation of journalists. Less well known is his role as an innovator in journalism. In 2003, he became the first blogger for The New York Times website.
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