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Articles by David Cotter
Laboratory Workup and Mast Cell Pathophysiology in CIndU
From Avoidance to Action: Emerging Therapies for Management of Chronic Inducible Urticaria - Episode 2 Published on: , , Targeted laboratory testing and an understanding of the type I and type IIb immune pathways help clinicians characterize CIndU and explain to patients why their skin reacts the way it does. In "Laboratory Workup and Mast Cell Pathophysiology in CIndU," the panel moves from the history to the bloodwork and the biology beneath it.
CIndU Subtypes, Overlap With CSU, and Practical Provocation Testing
From Avoidance to Action: Emerging Therapies for Management of Chronic Inducible Urticaria - Episode 1 Published on: , , Chronic inducible urticaria spans many subtypes and frequently overlaps with chronic spontaneous urticaria, making careful history taking and pragmatic provocation testing central to an accurate diagnosis. Welcome back to another HCPLive Peer Exchange series.
BE BOLD and the Case for IL-17 Inhibition in Psoriatic Arthritis, With David Cotter, MD, PhD
Bimekizumab (Bimzelx), a dual IL-17A/F inhibitor, achieved superior ACR50 response over the IL-23 inhibitor risankizumab (Skyrizi) in active psoriatic arthritis (PsA) in the phase 3b BE BOLD trial (NCT06624228), according to David Cotter, MD, PhD, a board-certified dermatologist at Las Vegas Dermatology and assistant clinical professor at the Kirk Kerkorian School of Medicine at the University of Nevada, Las Vegas.
A two-house party
Handel and Hendrix share a house — and, surprisingly, make rather good party companions Two blue plaques and two front doors. Brook Street is home to one of London’s most improbable musical coincidences. George Frideric Handel lived at No. 25 from 1723 until his death in 1759; Jimi Hendrix moved into the adjoining No. 23 in 1968; and, last weekend, Handel Hendrix House decided to throw a party.
How Online-Informed Patients Are Changing Dermatology Visits
In recent years, the rise of the “online-informed” patient has transformed visits to dermatology practices, with clinicians increasingly encountering patients who greet them armed with TikTok skincare advice, Reddit-informed treatment data, AI-generated differential diagnoses, and screenshots from ChatGPT inquiries. In this feature, interviews between 4 leaders in dermatology and HCPLive highlight this trend as being simultaneously empowering to patients and potentially hazardous.
Positive Results Identified for Risankizumab and Other Psoriasis Drugs, With David Cotter, MD, PhD
In a new interview with HCPLive, David Cotter, MD, PhD, assistant clinical professor at the University of Nevada, shared his perspective on new data and recent developments in psoriasis management highlighted during the 2026 American Academy of Dermatology (AAD) Annual Meeting in Denver.1,2 In his discussion with HCPLive on the floor of the 2026 AAD meeting, Cotter offered an enthusiastic and candid tour of what he sees as the most clinically meaningful developments in psoriasis currently,...
Characterising a stress-sensitive default mode network (DMN) deficit in major psychiatric disorders - Communications Biology
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Abstract Childhood trauma (CT) is associated with cognitive impairment across major psychiatric disorders. We tested a novel transdiagnostic hypothesis that atypical connectivity of the default mode network (DMN) mediates the association between childhood trauma (CT) and cognitive impairment. The sample of 1851 individuals aged 18-25 included 433 patients with depression, eating disorders, alcohol use disorder, psychosis and ADHD) and were recruited as part of the ESTRA/STRATIFY/IMAGEN studies.
By Sinead King, Zuo Zhang, Lauren Robinson, Robert Whelan, Frauke Nees, Marina Bobou, Tobias Banaschewski, Gareth Barker, Arun Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Luise Poustka, Sarah Hohmann, Nathalie E. Holz, Christian Baeuchl, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Jeanne M Winterer, Betteke van Noort, Argyris Stringaris, Yuning Zhang, Julia Sinclair, Gunter Schumann, Ulrike Schmidt, Sylvane Desrivières, David Cotter, Allan Young, Gary Donohoe, Eric Wolsztynski, M. John Broulidakis
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Nature
Verified
Closing Thoughts on the Impact of IL-23s in Psoriasis and Psoriatic Arthritis
Redefining Psoriasis Care: Expert Perspectives of Emerging Data on Novel Treatment Modalities - Episode 17 Published on: , , Final reflections from physicians Stein Gold, Soung, and Cotter, emphasizing multidisciplinary, patient-focused advances in psoriasis and PsA care. This Peer Exchange opens by addressing persistent gaps in psoriasis care, despite the expanding therapeutic landscape.
Current Treatment Landscape in Psoriatic Arthritis
Redefining Psoriasis Care: Expert Perspectives of Emerging Data on Novel Treatment Modalities - Episode 15 Published on: , , Comparison of APEX findings to prior IL-23 trials such as KEEPSAKE-1 and their implications for clinical practice. This Peer Exchange opens by addressing persistent gaps in psoriasis care, despite the expanding therapeutic landscape.
Seborrheic Dermatitis in the United States: Stable National Rates With Marked State‐Level Variation, 2010-2021
No abstract is available for this article. Conflicts of Interest A.G. is an unpaid official Senior Collaborator for IHME/GBD. He serves as an Associate Editor for the Journal of Investigative Dermatology and the International Journal of Dermatology, a Physician Editor for VisualDx, a member of the Board of Directors for the Biology of Skin Foundation, and a Medical Director at AbbVie.
Screening for Psoriatic Arthritis in Patients With Psoriasis
Redefining Psoriasis Care: Expert Perspectives of Emerging Data on Novel Treatment Modalities - Episode 13 Published on: , , The panel discusses the prevalence and risk factors for psoriasis progression to psoriatic arthritis. This Peer Exchange opens by addressing persistent gaps in psoriasis care, despite the expanding therapeutic landscape.
Expert Perspectives on First-In-Class IL-23 Oral Peptide
Redefining Psoriasis Care: Expert Perspectives of Emerging Data on Novel Treatment Modalities - Episode 11 Published on: , , Examination of unique challenges and the importance of early, effective therapy in younger patients. This Peer Exchange opens by addressing persistent gaps in psoriasis care, despite the expanding therapeutic landscape.
Treating High-Impact Areas in Psoriasis: Results From the ICONIC-TOTAL and SPECTREM Trials
Redefining Psoriasis Care: Expert Perspectives of Emerging Data on Novel Treatment Modalities - Episode 9 Published on: , , Discussion of nasopharyngitis and URTI as the most common AEs and how the safety profile compares to other oral agents. This Peer Exchange opens by addressing persistent gaps in psoriasis care, despite the expanding therapeutic landscape.
Erosive Oral Lichen Planus Treated With Upadacitinib Amid Systemic Psoriatic Therapy
Specialty Please choose I'm not a medical professional. Allergy and Immunology Anatomy Anesthesiology Biostatistics Cardiac/Thoracic/Vascular Surgery Cardiology Critical Care Dentistry Dermatology Diabetes and Endocrinology Emergency Medicine Epidemiology and Public Health Family Medicine Forensic Medicine Gastroenterology General Practice Genetics Geriatrics Health Policy Hematology HIV/AIDS Hospital-based Medicine I'm not a medical professional.
A Novel Treatment in Psoriasis: Expert Perspectives on the ICONIC-LEAD Trial
Redefining Psoriasis Care: Expert Perspectives of Emerging Data on Novel Treatment Modalities - Episode 7 Published on: , , Jennifer Soung, MD, outlines ICO’s mechanism as an IL-23 receptor antagonist and its significance in oral systemic therapy. This Peer Exchange opens by addressing persistent gaps in psoriasis care, despite the expanding therapeutic landscape.
An Overview of Treat-to-Target in Psoriasis
Redefining Psoriasis Care: Expert Perspectives of Emerging Data on Novel Treatment Modalities - Episode 5 Published on: , , Review of the updated IPC framework defining topical failure, reducing “topical churn,” and guiding earlier systemic escalation. This Peer Exchange opens by addressing persistent gaps in psoriasis care, despite the expanding therapeutic landscape.
Expert Perspectives on When to Discuss Psoriatic Arthritis With Patients
Redefining Psoriasis Care: Expert Perspectives of Emerging Data on Novel Treatment Modalities - Episode 3 Published on: , , Discussion on how patient goals, treatment experiences, and preference for oral agents shape individualized therapy plans. This Peer Exchange opens by addressing persistent gaps in psoriasis care, despite the expanding therapeutic landscape.
Initial Diagnostic Workup for Patients Presenting With Psoriasis Symptoms
Redefining Psoriasis Care: Expert Perspectives of Emerging Data on Novel Treatment Modalities - Episode 1 Published on: , , Dr. Stein Gold introduces the panel and outlines the discussion’s focus on emerging therapies and evolving clinical approaches in psoriasis and PsA management. This Peer Exchange opens by addressing persistent gaps in psoriasis care, despite the expanding therapeutic landscape.
Facial Pyoderma Gangrenosum Revealing Inflammatory Bowel Disease After Prior Total Colectomy
Specialty Please choose I'm not a medical professional. Allergy and Immunology Anatomy Anesthesiology Biostatistics Cardiac/Thoracic/Vascular Surgery Cardiology Critical Care Dentistry Dermatology Diabetes and Endocrinology Emergency Medicine Epidemiology and Public Health Family Medicine Forensic Medicine Gastroenterology General Practice Genetics Geriatrics Health Policy Hematology HIV/AIDS Hospital-based Medicine I'm not a medical professional.
Cell-type-specific DNA methylation dynamics in the prenatal and postnatal human cortex
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Keywords DNA methylation cortex development aging schizophrenia autism epigenetics fetal brain neuronal Introduction Development of the human cortex is a complex and highly orchestrated process underpinned by the temporally coordinated regulation of gene expression.1 Starting with the rapid proliferation of neural progenitor cells in the ventricular zone, these transcriptional programs drive key developmental processes, including neurogenesis and synaptogenesis, and act to regulate neuronal...
By Alice Franklin, Jonathan Davies, Nicholas E. Clifton, Georgina Blake, Rosemary A. Bamford, Emma Walker, Barry Chioza, Simon Baron-Cohen, Carrie Allison, Varun Warrier, Alex Tsompanidis, Deep Adhya, Rosie Holt, Joanna O'Donnell Verified, Niran Okewole, Daniel H Geschwind, Alexander E.P. Heazell, Jonathan Mill, Matthew E Hurles, Hilary C. Martin, Mahmoud M. Mousa, David H. Rowitch, Kathy K. Niakan, Graham J Burton, Deepak Srivastava, Lucia Dutan-Polit, Adam Pavlinek, Laura Sichlinger, Roland Nagy, Madeline A. Lancaster, Jose Gonzalez-Martinez, Tal Biron-Shental, Lidia V. Gabis, Dori Floris, Richard A. I. Bethlehem, Mike Lombardo, Marcin A. Radecki, Meng-Chuan Lai, Elizabeth Weir, Florina Uzefovsky, Yumnah T. Khan, Anna A. Penn, Rebecca C. Knickmeyer, Kyriaki Kosidou, Bart P Rutten, Sinan Guloksuz, Thérèse van Amelsvoort, Lotta-Katrin Pries, Bochao Danae Lin, Angelo Arias-Magnasco, Mary Cannon, David Cotter, Melanie Föcking, Subash Raj Susai, Elisabeth Binder Verified, Jim van Os, Jeroen Pasterkamp, Anna L. Wiersema, Marco P. Boks, Winni Schalkwijk, Karim Lekadir, Esmeralda Ruiz Pujadas, Ian Kelleher, Jenni Leppanen, Valentina Kieseppä, Simona Karbouniaris, Marijke Kolk, Jordi Rambla, Arcadi Navarro, Liina Nagirnaja, Jaanus Harro, Dejan Stevanovic, Jasna Jancic, Marija Nikolić, Laura Giani, Tomislav Franic, Mia Plenkovic, Covadonga M Díaz-Caneja, Celso Arango, Christel M. Middeldorp, Enda M. Byrne, Sushma Marla, Eilis Hannon, Emma Dempster, Philippa M Wells, Robin Murray Verified, Andrea Danese, Alexander Richards, Lucy Riglin, Michael O’Donovan, Joe Burrage, Nick Owens, Shyam Prabhakar, Martyn Frith, Genie Gu, Yira Zhang, Omar Al-Rubaie, Fateneh Ghafari, Yeshaya David Greenberg, Erika van Hell, Noussair Lazrak, Mariël Kanne, Hanske Douwenga, Aldar Cabrelles Munoz, Lauren A. Fromont, Triin Kurrikoff, Reigo Reppo, Aleksa Milevic, Maria Bulgheroni, Margherita La Gamba, Marta Ferrer-Quintero, Renzo Abregú-Crespo, Emily Guerra-Blacio, Nuria Martín-Martínez, Swathi Hassan Gangaraju
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Cell Press
Verified
How Gene Expression Profiling Works in Skin Cancer, with David Cotter, MD, PhD
In a session presented during the Dermatology Education Foundation (DERM) 2025 NP/PA CME Conference in Las Vegas, David Cotter, MD, PhD, of Las Vegas Dermatology, spoke about gene expression profiling of skin cancer.1 Cotter highlighted the integration of artificial intelligence (AI) and molecular testing in dermatology, specifically gene expression profiling, which examines gene activity in cells to predict behavior.
How to Use Artificial Intelligence Tools in Dermatology, with David Cotter, MD, PhD
The expanding use of artificial intelligence (AI) tools for clinicians, and specifically dermatologists, has been increasingly discussed both in a positive and negative light. At the Dermatology Education Foundation (DERM) 2025 NP/PA CME Conference in Las Vegas, session presenter David Cotter, MD, PhD, of Las Vegas Dermatology, spoke with HCPLive about a talk he gave on this subject.
The world’s greatest classical music festival?
This is democracy manifest The “world’s greatest classical music festival”. Such has been the tagline of the BBC Proms for as long as I, at least, can remember. But is there weight to this claim? Founded by the musical impresario Robert Newman, the Proms has run continuously since 1895 — save for short wartime interruptions — and, on balance, its audience size, duration, global reach, prestige, access, and cost are unrivalled.
Democratising the Proms should not mean dumbing them down
Creating a public for classical music means challenging and not patronising listeners The “world’s greatest classical music festival”. Such has been the tagline for the BBC Proms for as long as I, at least, can remember. But is their weight to this claim? Founded by the musical impresario Robert Newman, the Proms has run continuously since 1895 — save for short wartime interruptions — and, on balance, its audience size, duration, global reach, prestige, access, and cost are unrivalled.
HCPLive Five at SDPA 2025
Published on: , , , , Check out insights from SDPA 2025 on eczema, alopecia, vitiligo, burnout, and JAK inhibitor workups—key tips to improve dermatology care. In late June, physician assistants convened at the SDPA Annual Summer Dermatology Conference in Washington, DC, from June 25 – June 29th, to attend talks from other physician assistants and clinicians. The meeting was heavily centered around hair loss and treating skin conditions in people of color.
The Workup Before Initiating a JAK Inhibitor for Alopecia, With David Cotter, MD, PhD
Before prescribing a patient with alopecia areata a JAK inhibitor, what should you do? At the 2025 Society of Dermatology Physician Assistant (SDPA) annual summer meeting in Washington, DC, HCPLive spoke with David Cotter, MD, PhD, an assistant clinical professor at the University of Nevada, on the workup before initiating a JAK inhibitor for alopecia areata, key safety concerns for JAK inhibitors, and his perspective on JAK inhibitor use in younger patients.
JAK Inhibitors Show Promise Across Alopecia Subtypes, Says David Cotter, MD, PhD
At the 2025 Society of Dermatology Physician Assistant (SDPA) annual summer meeting in Washington, DC, David Cotter, MD, PhD, an assistant clinical professor at the University of Nevada, presented the session, “Hair Loss Track: JAK-ing Up Alopecia Areata,” on Friday, June 27th.
Body fluid biomarkers and psychosis risk in The Accelerating Medicines Partnership® Schizophrenia Program: design considerations - Schizophrenia
Abstract Advances in proteomic assay methodologies and genomics have significantly improved our understanding of the blood proteome. Schizophrenia and psychosis risk are linked to polygenic scores for schizophrenia and other mental disorders, as well as to altered blood and saliva levels of biomarkers involved in hormonal signaling, redox balance, and chronic systemic inflammation.
Breakfast with Tina Brown — BSME
The BSME hosted a compelling breakfast event this week featuring renowned former Vanity Fair and The New Yorker editor and author, Tina Brown CBE. Held at the Scarfes Bar in the Rosewood Hotel, it featured the award winning journalist in conversation with Andrea Thompson, BSME chair and editor-in-chief of Marie Claire about her illustrious career, navigating the industry as a woman, and delving into our current media landscape.
AI & journalism – how to make AI your friend — BSME
Twenty-five years ago, the internet revolution began to transform the media world. With AI, the changes will be foundational – but does that present a threat or an opportunity? On Thursday 24 April, the BSME brought together an expert panel at the Bankside Hotel.
In conversation with Emma Barnett — BSME
This week, in celebration of International Women’s Month, The BSME and Rosewood London hosted an inspiring discussion lead by Andrea Thompson, chair of the BSME and editor-in-chief of Marie Claire, in conversation with renowned journalist and broadcaster Emma Barnett.
David Cotter
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Bridging the journalism and advertising divide — BSME
Just days after Meta announced it was rolling back on fact-checking and with trusted reporting facing new challenges in the second Trump era, BSME members came together to discuss how to bridge the divide between journalism and advertising.
Spotify Wrapped is good for the soul
On the joys of exploring a year in music Now that the wrappings have been peeled back from our yearly listening lists, with what have we been left? The commodification of personality in the age of digital information, the affirmation of in-group identity in our attention economy, or a celebration of music as the force of human relationality? Like an excited child, each Advent I await the unveiling of Spotify Wrapped: a musical time capsule diarising the highs and lows of the year.
Reporting on the Year of Elections — BSME
2024 is the year of elections but how is the role of trusted journalism changing in an increasingly polarised world where social media is dominant and misinformation is rife? At this BSME event, we spoke to leading political journalists and editors about the recent general election and the early days of Keir Starmer's new government, plus we discussed the forthcoming US Presidential vote and broader trends when it comes to reporting on politics in the UK and around the world.
Secrets of subscription strategy: new ways to engage audiences and drive growth — BSME
Members of the BSME came together last week to discuss the secrets of subscriptions and how to execute them. The panel was hosted by Dan Green, editor of The Week Junior Science+Nature, featured insights from Catherine de Lange, editor of New Scientist, Nick de Semlyen, editor of Empire, Maisie McCabe, editor of Campaign and Abi Spooner, strategy partner at Atlas. Bauer Media hosted the panel discussion at the company’s recently-opened London headquarters, The Lantern.
In conversation with Edward Enninful at Rosewood London — BSME
The BSME hosted an unforgettable lunch with fashion and magazine trailblazer Edward Enninful OBE, who had been at the helm of British Vogue for six years before becoming global creative and cultural advisor for Vogue and editorial advisor for British Vogue.
BSME chair 2024 - BSME
The British Society of Magazine Editors (BSME) has announced the appointment of Gideon Spanier, UK editor-in-chief at Campaign, as its 2024 chair, succeeding Deborah Joseph, European editorial director at GLAMOUR UK. Gideon Spanier will be supported by vice-chairs Laura Bartlett, founding editor-in-chief at House of Coco,Chris Lupton, creative director at Empire and Andrea Thompson, editor-in-chief at Marie Claire.
Saltburn and the significance of sound
Why has Sophie Ellis-Bextor’s “Murder on the Dancefloor” caught the world’s attention again? The role of the sonic in amplifying the visual is profound. Mainstream motion pictures from at least the start of the 20th century have used music – by means of creating sounds, soundscapes, soundtracks, and curating pre-existing pieces – to mediate atmosphere, attention, and emotion. A film with little or no music is a rare thing indeed.
Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory imbalance in striatal D1-neurons - Translational Psychiatry
Abstract Striatal dysfunction has been implicated in the pathophysiology of schizophrenia, a disorder characterized by positive symptoms such as hallucinations and delusions. Haloperidol is a typical antipsychotic medication used in the treatment of schizophrenia that is known to antagonize dopamine D2 receptors, which are abundantly expressed in the striatum.
Predicting childhood ADHD-linked symptoms from prenatal and perinatal data in the ABCD cohort
Strengths and limitations The main strengths of this study are its use of a large data set and the inclusion of wide range of prenatal/perinatal factors. There are few studies in this area which possess both these methodological strengths. Second, use of elastic net regression and 5-fold validation to identify robust predictors of attention problems was novel, and appropriate for this set of correlated pre/perinatal predictors (Figure S6).
Burnout: Is Personal Happiness the Answer?
Podcast | January 9, 2023 The Practical Dermatology Podcast There’s no paucity of studies for biologic therapies used to treat psoriatic disease, but the number of head-to-head trials comparing these agents is limited. Enter network meta-analysis, a statistical methodology that has emerged over the past few years to compare medication.
The human subject
Tár is a film of moving ambiguities “It’s always the question that involves the listener. It’s never the answer, right?” As the eponymous protagonist Lydia Tár (Cate Blanchett) explains to her student, musical questions are always more interesting than their answers. Exactly the same can be said of the film, which ultimately conceals more than it ever reveals. Its ambiguity is profoundly compelling.
Weighing the Role of Network Meta-analysis for Choosing Biologic Therapies in Psoriatic Disease
There’s no paucity of studies for biologic therapies used to treat psoriatic disease, but the number of head-to-head trials comparing these agents is limited. Enter network meta-analysis, a statistical methodology that has emerged over the past few years to compare medication.
Why investigative magazine journalism matters more than ever — BSME
Join BSME vice chair and editor of Pulse, Jamie Kaffash, when he spoke to Rachel Oldroyd, recent editor of The Bureau of Investigative Journalism, Harry Rose, editor of Which? and Peter Apps, news editor at Inside Housing, about producing great investigative journalism, its essential role in society, avoiding the pitfalls and how it can benefit your magazines and brands.
Crown CFO to Take on COO Role Too
Crown Laboratories Chief Financial Officer (CFO) Nadeem Moiz will take on expanded responsibilities as Chief Operations Officer (COO). This appointment is made as Jack Songster, Crown's current COO, is set to retire on July 15. In this dual role, Mr. Moiz will focus on both financial and manufacturing leadership and operations.
Cynosure's New Tempsure eyeEnvi Handpiece Offers Improved Function and Greater Comfort
Cynosure has added a new Tempsure eyeEnvi handpiece to its portfolio. Featuring innovative ergonomic pencil grip design and lighter piston tension required to activate the treatment, the company says the new handpiece is more comfortable for patients and providers, heating thinner tissue more effectively and comfortably while minimizing hand fatigue.
SCUBE3 May Stimulate Hair Growth
University of California, Irvine-led researchers have discovered that a signaling molecule called SCUBE3 potently stimulates hair growth and may offer a therapeutic treatment for androgenetic alopecia, according to a study published in Developmental Cell, .Although it’s well known that dermal papilla cells play a pivotal role in controlling hair growth, the genetic basis of the activating molecules involved has been poorly understood until now.
Pro Tip: Addressing Marginal Mandibular Nerve Paresis Following Submental Deoxycholate Injections
Marginal mandibular nerve paresis can occur following submental deoxycholate injections, but this can be addressed and treated quickly to the patient’s satisfaction using two neuromodulators. The potential problem Kybella (Deoxycholate) remains the only FDA-approved injectable treatment for the reduction of submental fat. Mandibular nerve paresis may result in a temporary asymmetric smile and/or facial muscle weakness that can last for more than a month.
NYC PrideFest: Galderma Aesthetics to Participate
Galderma is participating in New York City's official LGBTQIA+ Pride (NYC Pride) event. This month marks the official launch of Restylane's "XpresYourself" communications campaign, which gives a nod to Restylane's XpresHAn Technology™, a unique manufacturing process in four Restylane products that allows them to maintain natural movement and expressions for natural-looking results.
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