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David Sinclair on Muck Rack

David Sinclair

Boston, Harvard
As seen in: Lifespan with Dr. David Sinclair, National Institutes of Health, Wiley Online Library, British Pharmacological Society, PLOS Biology, JAMA (The Journal of the American Medical Association), Cell Metabolism, Cell Press, Cell Reports, Lexology, RealClear Science and
Professor researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own. @joinlifespan
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Articles

Organising general practice for care homes: a multi-method study

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By David Sinclair
| National Institutes of Health
Abstract Background: General practice provides first-line National Health Service care for around 400,000 care home residents. Good primary care can enhance residents’ health and well-being and optimise use of hospital services. Objectives: This study aimed to explore the relationships between organisation of general practice and the perspectives and experiences of residents, general practice and care home staff, outcomes and costs.
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Loss of epigenetic information as a cause of mammalian aging

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By PATRICK GRIFFIN, David Sinclair
| Cell Press Verified
Main text (Cell 186, 305–326.e1–e14; January 19, 2023) Our paper used a system called “ICE” (inducible changes to the epigenome) to study whether a loss of epigenetic information leads to aging and whether the expression of a subset of Yamanka factors can reverse these age-associated changes, as tests of the Information Theory of Aging.
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Aging: past, present and future

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By David Sinclair
| National Institutes of Health
1. Rose MR. Evolutionary biology of aging. Oxford, UK: Oxford University Press; 1991. [Google Scholar] 2. Medawar PB. An unsolved problem in biology. London: HK Lewis; 1952. [Google Scholar] 3. Williams GC. Pleiotropy, natural selection, and the evolution of senescence. Evolution. 1957;11:398–411. [Google Scholar] 4. Kirkwood TB. Understanding the odd science of aging. Cell. 2005;120:437–447. [PubMed] [Google Scholar] 5. Osborne TB, Mendel LB, Ferry EL.
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