Domingo Barber

Keywords CD4+T cell immunometabolism phenylalanine allergy Th2 cells regulatory T cells metabolomics single-cell energy metabolism amino acid asthma Introduction Upon activation, naive CD4+T cells clonally expand and differentiate into several specialized effector (Teff) subsets, including T helper (Th) 1, Th2, and Th17, depending on the nature of antigen challenge and cues from the microenvironment.1 Regulatory CD4+CD25+T (Treg) cells arise either from thymus or from peripheral conversion of...

Abstract The human gut microbiome establishes and matures during infancy, and dysregulation at this stage may lead to pathologies later in life. We conducted a multi-omics study comprising three generations of family members to investigate the early development of the gut microbiota.

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