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Articles by Edit Ábrahám
Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses
ArticleOnline nowOpen access 1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 2Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 3Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA 4Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy 5Department of Pathology, University of Massachusetts Chan...
Tailoring the adjuvanticity of lipid nanoparticles by PEG lipid ratio and phospholipid modifications - Nature Nanotechnology
Abstract Lipid nanoparticles (LNPs) represent the leading delivery platform for mRNA vaccines with advantageous biocompatibility, scalability, adjuvant activity and often an acceptable safety profile.
Experimental horizontal transfer of phage-derived genes to Drosophila confers innate immunity to parasitoids
Keywords Drosophila innate immunity horizontal gene transfer phage parasitoid cdtB Introduction Invertebrates and vertebrates deploy deeply homologous innate immune pathways against microbial pathogens that are well understood.1,2,3,4,5,6 However, less is known about the evolution of innate immune pathways against metazoan parasites7 (macroparasites) that can cause chronic infections8 and facilitate Red Queen-like coevolutionary dynamics.7,9,10,11 Indeed, the local diversity of parasitic...
Versatile gamma-tubulin complexes contribute to the dynamic organization of MTOCs during Drosophila spermatogenesis - Communications Biology
Abstract The initiation of microtubule formation is facilitated by γ-tubulin and γ-Tubulin Ring Complex (γ-TuRC) in various microtubule-organizing centers (MTOCs). While the heterogeneity of tissue-specific MTOCs and γ-TuRC in Drosophila testis has been described, their molecular composition and physiological significance are poorly understood. We investigated the testis-specific distribution and biochemical interaction of the canonical γ-TuRC proteins Grip163 and Grip84.
Protein Phosphatase 4 Is Required for Centrobin Function in DNA Damage Repair
2. Materials and Methods 2.1. DNA Constructs cDNA-encoding human PPP4R3A isoform 1 (UniProt ID: Q6IN85; cDNA name: MHS6278-202759611, clone ID: 6142109), human PPP4R3B isoform 3 (UniProt ID: Q5MIZ7-3, cDNA name: MHS6278-202807853; clone ID: 5259789) and human Centrobin isoform 1 (UniProt ID: Q8N137-1; cDNA name: MHS6278-202832427, clone ID: 4859539) were originally generated by the Mammalian Gene Collection project [42] and we obtained from Horizon Discovery Ltd. (Cambridge, UK).
Protein phosphatase 4 is required for Centrobin function in DNA damage repair
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Plk4 Is a Novel Substrate of Protein Phosphatase 5
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