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Articles by Eric Ortlund
5 Reasons Christians Might Suffer and How to Respond to It
Categories of Suffering One necessary prerequisite for suffering well involves wise discernment about the different kinds of trials we undergo, how to recognize them, and what response our Lord wants from us in each. Steadfast and patient hope in God is appropriate in every season, but there are certain times of trial in which repentance is necessary—and other times in which we absolutely should not change. God’s word helps us in this.
Our Sorrows Keep Getting More Sorrowful and Joys Keep Getting More Joyful
Worse and Better Many years ago, as a young Christian, I listened to some tapes from the All Souls Tape Library of a series of talks by John Stott entitled “Tensions in Christian Experience.” I think one of them was on sorrow and joy.
Learn from Job How to Trust God Even Through Suffering
Suffering Produces Trust Job is one of five books in the middle of our Old Testament that are called “wisdom books”—Job, Psalms, Proverbs, Ecclesiastes, and Song of Solomon. In these books, there are no great events (like in the books of history or prophecy) and no new laws (like in the first five books of the Bible). These books aren’t so much about creation or God’s corporate people, Israel. Instead, these books focus on individual people who, in many respects, are like us.
The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases - Nature Communications
Abstract Corynebacterium diphtheriae clade species secrete single-domain endo-β-N-acetylglucosaminidases (ENGases) that specifically bind to human IgG antibodies and hydrolyze their N297-linked glycans. Here, we define the molecular mechanisms of IgG-specific deglycosylation for the entire family of corynebacterial IgG-specific ENGases, including but not limited to CU43 and CM49.
Epitope mapping via in vitro deep mutational scanning methods and its applications
The abbreviations used are DMS (deep mutational scanning) Fab (fragment-antigen binding region) HDX (hydrogen-deuterium exchange) PMA (peptide microarrays) p-MHC (peptide-major histocompatibility complex) APC (antigen-presenting cell) SABR (signaling and antigen presenting bifunctional receptor) IEDB (immune epitope database & tools) MS EL (mass spectrometry-derived eluted ligand) EM-DMS (epitope mapping via deep mutational scanning) SSM (site-saturation mutagenesis library) CFU (colony...
Author Correction: APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes - Nature
Correction to: Nature https://doi.org/10.1038/s41586-022-05439-w Published online 16 November 2022 In the version of the article initially published, the “Isolation of nuclei from frozen post-mortem brain tissue” and “Droplet-based snRNA-seq” sections of the Methods did not reference a partial overlap of human snRNA-sequencing samples with samples reported in a previous study1 (ref. 12 in the original article).
Autoantibodies immuno-mechanically modulate platelet contractile force and bleeding risk - Nature Communications
Abstract Altered mechanotransduction has been proposed as a putative mechanism for disease pathophysiology, yet evidence remains scarce. Here we introduce a concept we call single cell immuno-mechanical modulation, which links immunology, integrin biology, cellular mechanics, and disease pathophysiology and symptomology.
Is the Story of Job Historical? (Job 1)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 1 There was a man in the land of Uz whose name was Job, and that man was blameless and upright, one who feared God and turned away from evil. 2 There were born to him seven sons and three daughters. 3 He possessed 7,000 sheep, 3,000 camels, 500 yoke of oxen, and 500 female donkeys, and very many servants, so that this man was the greatest of all the people of the east.
The nuclear receptor LRH‐1 discriminates between ligands using distinct allosteric signaling circuits
Supporting Information Filename Description pro4754-sup-0001-Supinfo.docxWord 2007 document , 38.8 MB Table S1. Complexes used for MD simulations Table S2. Summary statistics for suboptimal paths analysis Figure S1. Interactions made by LRH-1 ligands Figure S2. Community analysis; Figure S3. N452A mutation.
Meet the authors: Dr. Eva Huber, Dr. Michael Groll, and Dr. Eric Ortlund
In this meet-the-author Q&A, Cell Press Community Review editor Leslie Nitsche speaks to Eric Ortlund as well as Eva Huber and Michael Groll from the Groll group about their recent Structure papers and their experiences publishing via Cell Press Community Review. Main text Cell Press Community Review is a new initiative allowing authors to submit their research manuscripts for simultaneous consideration at multiple journals.
Multiplatform analyses reveal distinct drivers of systemic pathogenesis in adult versus pediatric severe acute COVID-19 - Nature Communications
Abstract The pathogenesis of multi-organ dysfunction associated with severe acute SARS-CoV-2 infection remains poorly understood. Endothelial damage and microvascular thrombosis have been identified as drivers of COVID-19 severity, yet the mechanisms underlying these processes remain elusive. Here we show alterations in fluid shear stress-responsive pathways in critically ill COVID-19 adults as compared to non-COVID critically ill adults using a multiomics approach.
The Song of Songs for Singles
You may have heard how rates of depression (and even suicide) tend to rise during the Christmas season. What many consider the happiest time of the year is, for some, the hardest to get through. But Christmas is not the only time of year when this happens: Valentine’s Day can be excruciating for those without a valentine.
What Is New about the New Covenant? (Jeremiah 31)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 31Behold, the days are coming, declares the Lord, when I will make a new covenant with the house of Israel and the house of Judah, 32not like the covenant that I made with their fathers on the day when I took them by the hand to bring them out of the land of Egypt, my covenant that they broke, though I was their husband, declares the Lord.
The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits
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Who Were the Nations in Nebuchadnezzar’s Prophetic Dream? (Daniel 2)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 29To you, O king, as you lay in bed came thoughts of what would be after this, and he who reveals mysteries made known to you what is to be.
Who Were the Magi, and Why Did They Worship Jesus? (Matthew 2)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 1Now after Jesus was born in Bethlehem of Judea in the days of Herod the king, behold, wise men from the east came to Jerusalem, 2 saying, “Where is he who has been born king of the Jews?
Is It True That “All Is Vanity”? (Ecclesiastes 1)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 1The words of the Preacher, the son of David, king in Jerusalem. 2Vanity of vanities, says the Preacher, vanity of vanities! All is vanity. 3What does man gain by all the toil at which he toils under the sun?
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes - Nature
Abstract APOE4 is the strongest genetic risk factor for Alzheimer’s disease1,2,3. However, the effects of APOE4 on the human brain are not fully understood, limiting opportunities to develop targeted therapeutics for individuals carrying APOE4 and other risk factors for Alzheimer’s disease4,5,6,7,8.
Did a Prophet Really Lay on His Side for More than a Year? (Ezekiel 4)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 1“And you, son of man, take a brick and lay it before you, and engrave on it a city, even Jerusalem. 2And put siegeworks against it, and build a siege wall against it, and cast up a mound against it. Set camps also against it, and plant battering rams against it all around.
Is The Song of Solomon about God's Love or Human Love? (Song of Solomon 1)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage SHE 2 Let him kiss me with the kisses of his mouth! For your love is better than wine; 3 your anointing oils are fragrant; your name is oil poured out; therefore virgins love you. 4 Draw me after you; let us run. The king has brought me into his chambers. OTHERS We will exult and rejoice in you; we will extol your love more than wine; rightly do they love you.
Is it Okay to Pray a Curse on My Enemies? (Psalm 5)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 9 For there is no truth in their mouth; their inmost self is destruction; their throat is an open grave; they flatter with their tongue. 10 Make them bear their guilt, O God; let them fall by their own counsels; because of the abundance of their transgressions cast them out, for they have rebelled against you.
What to Say to Someone Suffering like Job
How to Speak to Job The book of Job does not directly tell us how to address Job-like suffering. But I think we can sketch what a helpful answer would be, if we take an approach exactly opposite from his friends. Our two compass points here are the note of condemnation that rings through almost every line of the friends’ speeches and the attitude of self-righteous superiority.
Why Does Paul Tell the Church to Deliver Someone to Satan? (1 Corinthians 5)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 1It is actually reported that there is sexual immorality among you, and of a kind that is not tolerated even among pagans, for a man has his father’s wife. 2And you are arrogant! Ought you not rather to mourn? Let him who has done this be removed from among you. 3For though absent in body, I am present in spirit; and as if present, I have already pronounced judgment on the one who did such a thing.
Does Rahab Show Us That It's Sometimes Okay to Lie? (Joshua 2)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 1 And Joshua the son of Nun sent two men secretly from Shittim as spies, saying, “Go, view the land, especially Jericho.” And they went and came into the house of a prostitute whose name was Rahab and lodged there.
Why Did Jesus Say, “On This Rock I Will Build My Church”? (Matthew 16)
This article is part of the Tough Passages series.
Who Are the 144,000? (Revelation 7)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 1After this I saw four angels standing at the four corners of the earth, holding back the four winds of the earth, that no wind might blow on earth or sea or against any tree.
What Is the Sin that Leads to Death? (1 John 5)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 16If anyone sees his brother committing a sin not leading to death, he shall ask, and God will give him life—to those who commit sins that do not lead to death. There is sin that leads to death; I do not say that one should pray for that. 17All wrongdoing is sin, but there is sin that does not lead to death.
Should Christians Always Submit to the Government? (Romans 13)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 1Let every person be subject to the governing authorities. For there is no authority except from God, and those that exist have been instituted by God. 2Therefore whoever resists the authorities resists what God has appointed, and those who resist will incur judgment. 3For rulers are not a terror to good conduct, but to bad. Would you have no fear of the one who is in authority?
The Book of Job Is a Book of Joy
Deep Joy “Joy” is probably the last word most of us would use to describe the book of Job. What could be less joyful than the nightmare of Job’s suffering in Job 1–2? And does anyone find it joyful to wade through over thirty chapters of intense, agonized poetry as Job and his friends try and try and fail to figure out why Job’s tragedy happened?
Suffering Wisely and Well
Format: Crossway+ members receive 30% off books. Learn more. Retail Price: $16.99 Availability: In Stock Why Suffering Exists: God’s Purpose for Pain in the Life of Job and throughout Scripture Why does God allow suffering? The pain of suffering can be overwhelmingly mysterious, but the Bible does provide answers. Throughout Scripture, God allows trials in order to accomplish specific purposes in the lives of his people.
We Are Both Job and Job’s Friends
Seeing Ourselves in Scripture One important question in reading any biblical text is who you, as a reader, identify with. This is easier for some texts than for others, of course. In Genesis, for example, it is not difficult to identify with the patriarchs as they struggle and endure in trusting God’s promises to bless them and redeem creation. But who do we identify with in the book of Job?
Entering into the Loneliness of Job
Job 2:11–13 11Now when Job’s three friends heard of all this evil that had come upon him, they came each from his own place, Eliphaz the Temanite, Bildad the Shuhite, and Zophar the Naamathite. They made an appointment together to come to show him sympathy and comfort him. 12And when they saw him from a distance, they did not recognize him. And they raised their voices and wept, and they tore their robes and sprinkled dust on their heads toward heaven.
Did Jesus Forbid Us from Taking Oaths? (Matthew 5)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 33“Again you have heard that it was said to those of old, ‘You shall not swear falsely, but shall perform to the Lord what you have sworn.’ 34But I say to you, Do not take an oath at all, either by heaven, for it is the throne of God, 35 or by the earth, for it is his footstool, or by Jerusalem, for it is the city of the great King.
What Was Paul's Thorn in the Flesh? (2 Corinthians 12)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 7 So to keep me from becoming conceited because of the surpassing greatness of the revelations, a thorn was given me in the flesh, a messenger of Satan to harass me, to keep me from becoming conceited. 8 Three times I pleaded with the Lord about this, that it should leave me.
What Did John Mean When He Called Jesus the “Word”? (John 1)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 1In the beginning was the Word, and the Word was with God, and the Word was God. 2He was in the beginning with God. 3All things were made through him, and without him was not any thing made that was made. 4In him was life, and the life was the light of men. 5The light shines in the darkness, and the darkness has not overcome it.
How Does Jesus Respond When We Doubt? (John 20)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 24Now Thomas, one of the twelve, called the Twin, was not with them when Jesus came. 25So the other disciples told him, “We have seen the Lord.” But he said to them, “Unless I see in his hands the mark of the nails, and place my finger into the mark of the nails, and place my hand into his side, I will never believe.” 26Eight days later, his disciples were inside again, and Thomas was with them.
Did Jesus Really Mean That We Should Hate Our Families? (Luke 14)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 25Now great crowds accompanied him, and he turned and said to them, 26“If anyone comes to me and does not hate his own father and mother and wife and children and brothers and sisters, yes, and even his own life, he cannot be my disciple. 27Whoever does not bear his own cross and come after me cannot be my disciple.
Was Christ’s Coming the End of the Law? (Romans 10)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 4For Christ is the end of the law for righteousness to everyone who believes.5For Moses writes about the righteousness that is based on the law, that the person who does the commandments shall live by them.
Did Jesus Come to Bring Peace or a Sword? (Luke 12)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 49“I came to cast fire on the earth, and would that it were already kindled! 50 I have a baptism to be baptized with, and how great is my distress until it is accomplished! 51Do you think that I have come to give peace on earth? No, I tell you, but rather division. 52 For from now on in one house there will be five divided, three against two and two against three.
What Does It Mean That All Israel Will Be Saved? (Romans 11)
This article is part of the Tough Passages series. Listen to the Passage Read the Passage 25Lest you be wise in your own sight, I do not want you to be unaware of this mystery, brothers: a partial hardening has come upon Israel, until the fullness of the Gentiles has come in.
ESV Expository Commentary
Designed to help the church understand and apply the overarching storyline of the Bible, the ESV Expository Commentary is broadly accessible, theologically enriching, and pastorally wise. It features clear, crisp, and Christ-centered exposition and application from a team of respected pastor-theologians.
Rewiring Ancient Residue Interaction Networks Drove the Evolution of Specificity in Steroid Receptors
Highlights • Ancestral steroid receptors evolved distinct ligand-specific allosteric networks • Ligand-sensing residues modulate these networks to enable ligand discrimination • Sensors represent an evolutionarily conserved feature of steroid receptor signaling Summary Understanding how changes in amino acid sequence alter protein dynamics and allosteric signaling would illuminate strategies for protein design.
Oak Hill College: Christ, contextualization, and cherry blossoms
I was recently privileged to be able to teach a week-long class on the book of Job at Christ Bible Seminary in Nagoya, Japan. I use the word âprivilegedâ deliberately, since Japan is a culture of great beauty and great need. â That Japan is a beautiful culture will be obvious to anyone whoâs so much as looked at photos of the country. Even large urban centers like Nagoya are dotted with gardens and shrines which show a kind of loveliness not found in many other places.
Ancient protein flexibility can drive 'new' functions
A mechanism by which stress hormones inhibit the immune system, which appeared to be relatively new in evolution, may actually be hundreds of millions of years old. A protein called the glucocorticoid receptor or GR, which responds to the stress hormone cortisol, can take on two different forms to bind DNA: one for activating gene activity, and one for repressing it. In a paper published Dec.
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