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Articles by Eric Perkey
Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs
1Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA 2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA 3Department of Immunobiology, University of Lausanne, Epalinges, Switzerland 4Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA 5Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA, USA 6Children’s Hospital of Philadelphia,...
Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs
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1Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA 2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA 3Department of Immunobiology, University of Lausanne, Epalinges, Switzerland 4Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA 5Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA, USA 6Children’s Hospital of Philadelphia,...
By Anneka Allman, Brian T. Gaudette, Samantha Kelly, Nagham Alouche, Léolène J. Carrington, Eric Perkey, Joshua D Brandstadter, Ashley N. Vanderbeck, Katlyn Lederer, Yeqiao Zhou, Robert B. Faryabi, Tanner F. Robertson, Janis K. Burkhardt, Anastasia Tikhonova, Iannis Aifantis, Leonardo Scarpellino, Ute Koch, Freddy Radtke, Mechthild Lütge, Angelina De Martin, Burkhard Ludewig, Lena Tveriakhina, Achim Gossler, Lluc Mosteiro, Christian W. Siebel, Daniela Gomez Atria, Sanjiv A. Luther, David Allman, Ivan Maillard
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Cell Press
Verified
Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies
Highlights • Single-cell RNA-seq reveals CD19 expression in human brain mural cells • Mural cells line blood vessels and maintain blood-brain barrier integrity • Brain mural cell CD19 expression is present across brain regions and human age • Targeting CD19+ mural cells may contribute to neurotoxicity of CAR-T therapy Summary CD19-directed immunotherapies are clinically effective for treating B cell malignancies but also cause a high incidence of neurotoxicity.
Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies
Armulik A. Genové G. Mäe M. Nisancioglu M.H. Wallgard E. Niaudet C. He L. Norlin J. Lindblom P. Strittmatter K. et al. Pericytes regulate the blood-brain barrier. Nature. 2010; 468: 557-561 Bausch-Fluck D. Hofmann A. Bock T. Frei A.P. Cerciello F. Jacobs A. Moest H. Omasits U. Gundry R.L. Yoon C. et al. A mass spectrometric-derived cell surface protein atlas. PLoS ONE. 2015; 10: e0121314 Boroujerdi A. Tigges U. Welser-Alves J.V. Milner R. Isolation and culture of primary pericytes from mouse brain. Methods Mol. Biol.
GCNT1-Mediated O-Glycosylation of the Sialomucin CD43 Is a Sensitive Indicator of Notch Signaling in Activated T Cells
Eric Perkey, Dave Maurice De Sousa, Léolène Carrington, Jooho Chung, Alexander Dils, David Granadier, Ute Koch, Freddy Radtke, Burkhard Ludewig, Bruce R. Blazar, Christian W. Siebel, Todd V. Brennan, Jeffrey Nolz, Nathalie Labrecque and Ivan Maillard J Immunol March 15, 2020, 204 (6) 1674-1688; DOI: https://doi.org/10.4049/jimmunol.1901194 Key Points Notch signaling regulates Gcnt1-mediated core-2 O-glycosylation in activated T cells.
GCNT1-Mediated O-Glycosylation of the Sialomucin CD43 Is a Sensitive Indicator of Notch Signaling in Activated T Cells
Eric Perkey, Dave Maurice De Sousa, Léolène Carrington, Jooho Chung, Alexander Dils, David Granadier, Ute Koch, Freddy Radtke, Burkhard Ludewig, Bruce R. Blazar, Christian W. Siebel, Todd V. Brennan, Jeffrey Nolz, Nathalie Labrecque and Ivan Maillard J Immunol February 14, 2020, ji1901194; DOI: https://doi.org/10.4049/jimmunol.1901194 Key Points Notch signaling regulates Gcnt1-mediated core-2 O-glycosylation in activated T cells.
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