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Fadya Binyameen on Muck Rack

Fadya Binyameen

As seen in: Cell Reports
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Articles

Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes

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By Eirene Markenscoff-Papadimitriou, Fadya Binyameen, Sean Whalen
| Cell Reports Verified
Highlights • POGZ binds enhancers and promoters at euchromatic loci in the developing brain. • POGZ promotes neuronal gene expression and chromatin accessibility. • POGZ forms a nuclear complex with ADNP; Adnp expression is reduced in Pogz+/−. • POGZ bound sites are enriched for other autism risk genes and transposable elements.
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A Chromatin Accessibility Atlas of the Developing Human Telencephalon

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By Eirene Markenscoff-Papadimitriou, Sean Whalen, Pawel F. Przytycki, Reuben J. Thomas, Tomasz Nowakowski Verified, Arnold R. Kriegstein, Stephan Sanders, Katherine S. Pollard, John L. Rubenstein, Fadya Binyameen
| ScienceDirect Verified
Highlights • ∼19,000 enhancers defined in nine regions of the developing human telencephalon • Chromatin dynamics correlate with sequence motifs and spatiotemporal gene expression • Identified cortical layer-specific enhancers and validated a layer 5 FEZF2 enhancer • Genetic variants from patients alter activity of an enhancer for an autism risk gene Summary To discover regulatory elements driving the specificity of gene expression in different cell types and regions of the developing human...
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