Reuben J. Thomas

As we come out of our social distancing cocoons, looking to resume activities and relationships that have been put on hold for over a year, we may be entering a time of surging social activity that could reshape the bonds that connect us — for better or worse. Individuality is nurtured by the pursuit of a variety of nonoverlapping relationships, which allows people freedom to develop and express their identities.

Highlights • ∼19,000 enhancers defined in nine regions of the developing human telencephalon • Chromatin dynamics correlate with sequence motifs and spatiotemporal gene expression • Identified cortical layer-specific enhancers and validated a layer 5 FEZF2 enhancer • Genetic variants from patients alter activity of an enhancer for an autism risk gene Summary To discover regulatory elements driving the specificity of gene expression in different cell types and regions of the developing human...

Abstract The contraceptive effectiveness of intrauterine devices (IUDs) has been attributed in part to a foreign body reaction in the endometrium. We performed this study to better understand mechanisms of action of contraceptives of by studying their effects on endometrial and cervical transcriptomes.