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Articles by Fei Wu
Childhood socioeconomic status, cognitive reserve, and cognitive aging trajectories: a 10-year population-based cohort study
Abstract Childhood socioeconomic status (cSES) and cognitive reserve (CR) may shape late-life cognition, yet their distinct effects on cognitive level and age-related cognitive decline, and the mediating pathway through CR, remain unclear. Data were drawn from the Study on Ageing and Adult Health in China.
Whole-Genome Resequencing Reveals the Genetic Diversity and Adaptive Evolution of Rhabdophis nuchalis
BLAST basic local alignment search tool Gb gigabase pair Kb kilobase pair Mya million years ago padj adjusted p value PI3K phosphatidylinositol 3-kinase Rac Rac family small GTPases 1 Background Snakes represent a group of vertebrates with a high degree of morphological specialization (Zhao and Wang 2025). Current research indicates that snakes are widely distributed across all continents except for extreme polar environments (Jackson 2014).
A Hierarchical Architecture for Embodied Intelligence Systems: Enabling Embodied Intelligence Through Layered Decoupling and Unified Standards
Submitted: 24 September 2026 Posted: 25 September 2026 You are already at the latest version Embodied intelligence, at the frontier where artificial intelligence extends into the physical world, has become a major focus of both academia and industry. Its rapid expansion, however, has exposed serious challenges, including system complexity, tight hardware--software coupling, and barriers to industrial deployment.
General Relativity and Quantum Cosmology
We apply physics-informed neural networks (PINNs) to recover the time-time component of static, spherically symmetric black-hole exterior metrics from a reduced ordinary differential equation (ODE). Inspired by recent work on solving Einstein field equations with deep learning~\cite{Li2023}, we encode the vacuum/charged exterior through a residual loss and an asymptotic boundary constraint---not by embedding analytic metric terms such as $2M/r$ directly into the network output.
Automated screening of autism via a pretrained vision-language model in naturalistic caregiver-child interactions
Abstract Early autism screening is essential for timely intervention but remains constrained by specialist dependence, costly protocols, and limited accessibility. We present Autism-CLIP, a vision-language model that automates screening from 3-min naturalistic caregiver-child interaction videos recorded in toddlers aged 15–24 months.
Toward precision psychiatry: integrating pharmacogenomics and multimodal clinical data for personalized antidepressant response prediction
Abstract Individual responses to antidepressant treatment are highly heterogeneous, resulting in prolonged trial-and-error processes that undermine clinical outcomes. Pharmacogenomics (PGx) holds substantial promise for advancing precision psychiatry by guiding personalized antidepressant selection. However, existing PGx-based prescribing tools remain insufficiently validated and underutilized in real-world clinical practice.
Gut Microbiota Analysis and Comparison in Forest Musk Deer ( Moschus berezovskii ) of Different Ages and Musk-Secreting Periods
1 Introduction Forest musk deer (Moschus berezovskii, FMD), belonging to the family Moschidae (genus Moschus) (Yang et al. 2003), mainly lives in high-altitude coniferous or deciduous forests, alpine shrub meadows, and mountain forest grasslands in central and southwestern China (Fan et al. 2018a, 2018b), and a small population has also been reported in northeastern Vietnam (Tran et al. 2021).
Association between post-intravenous thrombolysis delirium and 90-day functional outcomes in patients with acute ischemic stroke
Abstract Objective: This study aimed to examine the association between post-Intravenous thrombolysis delirium and 90-day functional outcomes in patients with acute ischemic stroke (AIS). Methods: Patients admitted to the Second Hospital of Jiaxing within 24 hours of symptom onset who underwent intravenous thrombolysis for AIS between January 1, 2023, and December 31, 2024, were retrospectively analyzed.
Ultrawide-FOV full-color waveguides free of rainbow and fishbone artifacts via physics-constrained generative metagrating design
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Augmented reality (AR) displays are gaining prominence in consumer and industrial applications due to two-dimensional pupil-expanding waveguides, which achieve the essential dual requirements of compact form factors and large eyebox through innovative dual-axis beam replication...
Silica Nanoparticles Elicit Pulmonary Inflammation via STING-Dependent Activation of NF-κB p65 Signaling Pathway
You are already at the latest version Silica nanoparticles (SiNPs) are common nanoparticles that are widely used in industrial and medical applications. Inhalation exposure to SiNPs is frequently inevitable in modern society. While the adverse effects of SiNPs on lung injury have been extensively documented, the intrinsic mechanisms underlying SiNPs-induced pulmonary inflammation remain incompletely understood.
Computer Science > Artificial Intelligence
Reinforcement learning has emerged as an effective paradigm for enhancing the mathematical reasoning capabilities of large language models. Among existing policy optimization methods, Proximal Policy Optimization (PPO) remains particularly appealing because its learned critic can, in principle, provide token-level credit assignment.
RelB/ILF2–GM-CSF loop sustains tumor–MDSC communication in prostate cancer immunosuppression
Abstract Prostate cancer (PCa) exhibits an immune “cold” tumor microenvironment (TME) with significant enrichment of immunosuppressive myeloid-derived suppressor cells (MDSCs), which contribute to tumor progression and poor responses to immune checkpoint blockade (ICB). Although extensively studied, the precise mechanism underlying the tumor-intrinsic signals that educate and sustain the expansion and immunosuppressive function of MDSCs remains unelucidated.
SteuerLLM: local specialized large language model for German tax law analysis
Abstract Large language models (LLMs) demonstrate strong general reasoning and language understanding, yet their performance degrades in domains governed by strict formal rules, precise terminology, and legally binding structure. Tax law exemplifies these challenges, as correct answers require exact statutory citation, structured legal argumentation, and numerical accuracy under rigid grading schemes.
Research on prediction method for deformation and stabilization time of tunnels in squeezing surrounding rock based on seepage theory
Abstract Predicting the deformation and stabilization time of tunnels in squeezing surrounding rock is essential for deformation control during tunnel construction. This study proposes a seepage-theory-based prediction method for surrounding rock deformation and deformation stabilization time. First, the correlation between the seepage field and displacement field during tunnel excavation and support was analyzed through numerical simulation.
The pyroptosis cascade between inflammatory endothelial cells and microglia facilitates BBB disruption in bacterial meningitis
ArticleVolume 45, Issue 7117634Open access Affiliations & Notes 1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China 2Tianjin Institutes of Health Science, Tianjin 301600, China 3National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,...
Beta for Alpha: Neural Engagement in Financial Trading
We thank Hui Chen, Lauren Cohen, Davidson Heath, Nengjiu Ju, Yongxiang Wang, Hong Yan, Naide Ye, Songfa Zhong, Ning Zhu, and conference/seminar participants of the 20th International Behavioural Finance Conference, National Chengchi University, and Zhejiang University for helpful comments. The fieldwork received approval from the Institutional Review Boards (IRBs) of the University of Michigan. All errors are our own.
Palladium-Catalyzed Markovnikov Hydrocarbonylation of Aliphatic Olefins: A General Approach to Diverse Carbonyl Compounds Click to copy article link Article link copied!
Cite Jump to ExpandCollapse LetterJune 17, 2026 Palladium-Catalyzed Markovnikov Hydrocarbonylation of Aliphatic Olefins: A General Approach to Diverse Carbonyl Compounds Click to copy article linkArticle link copied! Fei Wu Fei Wu Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an 710127, P. R.
Computer Science > Computer Science and Game Theory
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Predicting cardiometabolic multimorbidity trajectory in middle-aged and older Chinese adults: insights from the cohort study on global ageing and adult health
Abstract Background: The ability to predict cardiometabolic multimorbidity (CMM) could significantly facilitate the identification of and intervention for middle-aged and older Chinese adults at risk. This study aimed to develop a prediction model for CMM progression trajectories based on multidimensional risk factors using an ensemble machine learning approach.
ANO1 stabilizes partial EMT to drive colorectal cancer metastasis through PI3K/AKT/mTOR and ERK signaling pathways
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Abstract Colorectal cancer (CRC) metastasis remains a clinically intractable challenge, where the partial epithelial-mesenchymal transition (partial EMT) state is a key driver of metastatic plasticity and treatment resistance. The calcium-activated chloride channel ANO1 (TMEM16A) is frequently overexpressed in epithelial tumors, yet its mechanism in regulating metastasis and partial EMT remains undefined. In this study, we identify ANO1 as a key stabilizer of the partial EMT state.
By Fei Wu, Kun Zhang, Zhenwu Du, Xin Li Verified, Longfei Yang, Linxian Zhao, Lili Nie, Qiwei Yang, Yujie Sui
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Nature
Verified
Dapagliflozin and linagliptin combination therapy improves time in range and reverses hepatic steatosis in patients with type 2 diabetes and hypertension
Abstract Background: Type 2 diabetes mellitus (T2DM) with comorbid hypertension increases risks of vascular complications, necessitating optimized therapies. This study evaluated whether dapagliflozin combined with linagliptin improves time in range (TIR) and hepatorenal function compared to monotherapy in this population.
Automated deep learning by recurrent hyperparameter optimization
Abstract Optimizing hyperparameters of deep learning models for specific tasks requires substantial domain expertise and computational resources, remaining challenging in automated deep learning. Existing hyperparameter optimization (HPO) methods are restricted to limited discrete hyperparameter types, rely on manual priors, and fail to scale to large datasets.
MRI-Derived Intra- and Peritumoral Heterogeneity for Predicting Response to Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma
Keywords Hepatocellular carcinoma Transarterial chemoembolization Intratumoral heterogeneity Peritumoral heterogeneity Treatment response Get full text access Log in, subscribe or purchase for full access. DATA AVAILABILITY All data generated or analyzed during the study are included in the published paper. References 1. Devarbhavi, H. ∙ Asrani, S.K. ∙ Arab, J.P. ... Global burden of liver disease: 2023 update J Hepatol. 2023; 79(2):516-537 2. Rumgay, H. ∙ Arnold, M. ∙ Ferlay, J. ...
Study on the evolution law of overlying strata movement inducing surface subsidence under different mining sequences of multiple coal seams: a case study
Abstract Reducing surface subsidence caused by coal mining is important for the coordinated development of efficient coal resource development and ecological environmental protection and remains a long-standing challenge.
A drone imagery dataset for semantic segmentation of urban garden ground covers in biodiversity studies
Abstract Urban gardens promote urban biodiversity by providing diverse ground covers that support habitat provision, pollination, pest control, and soil functions. However, lacking high spatial resolution images, their spatial heterogeneity remains poorly mapped, limiting our understanding of how these features support ecosystem services.
I Tried Internxt, an Encrypted, Secure Cloud Storage Built for the Post-Quantum Era
As a full-time creator and freelancer, I produce video content, manage brand partnerships and handle sensitive client data every day. Even if your files are encrypted, bad actors could be gaining access to them, or stealing your data today with a goal to unlock it tomorrow. A zero-knowledge, post-quantum encryption cloud storage service like Internxt can give you peace of mind. And you can use CNET’s special offer to get up to 87% off any Internxt paid plan. Claim the offer here.
Novel Unsupervised Machine Learning Model Using Multi-Parametric Radiomics for Prognostic Stratification of Bifocal Hepatocellular Carcinoma
Back to Journals » Journal of Hepatocellular Carcinoma » Volume 13 Authors Jia X, Wu F , Dai H, Xiao Y, Yang C, Zeng M Received 19 March 2026 Accepted for publication 8 May 2026 Published 19 May 2026 Volume 2026:13 606780 DOI https://doi.org/10.2147/JHC.S606780 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Mohamed Shaker Xi Jia,1,2,* Fei Wu,1,2,* Haoran Dai,1,2,* Yuyao Xiao,1,2 Chun Yang,1,2 Mengsu...
Advances in occult cancer screening for patients with unprovoked venous thromboembolism: A narrative review of epidemiology, risk, and clinical strategies
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Exploring nontrivial topology at quantum criticality on a superconducting processor - Communications Physics
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Abstract The discovery of nontrivial topology in quantum critical states has revised the classification of quantum phase transitions and opened a new direction for exploiting topological phases. However, the experimental investigation of gapless many-body systems is challenging due to the inherent complex quantum entanglement. Here, we demonstrate an experimental study of the topological properties in the critical cluster Ising model on a superconducting processor with up to 100 qubits.
By Ziqi Tan, Ke Wang, Fanhao Shen, Feitong Jin, Xuhao Zhu, Yujie Ji, Shibo Xu, Jiachen Chen, Yaozu Wu, Chuanyu Zhang, Yu Gao, Ning WANG, Yiren Zou, Aosai Zhang, Tingting Li, Zehang Bao, Zitian Zhu, Jiarun Zhong, Yihang Han, Yiyang He, Han Wang, Jianan Yang, Yanzhe Wang, Jiayuan Shen, Gongyu Liu, Zixuan Song, Jinfeng Deng, Hang Dong, Pengfei Zhang, Shao-Kai Jian, Hekang Li, Zhen Wang, Junxiang Zhang, Qiujiang Guo, Hai-Qing Lin, Xue-Jia Yu, H. Wang, Fei Wu, Zhengyi Cui
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Nature
Verified
FinTech-Real Economy Matching and Corporate Digital-Physical Technology Integration
1 Introduction In recent years, rapid advancements in digital technologies have increasingly permeated production, distribution, and service sectors, profoundly reshaping traditional production methods, industrial structures, and resource allocation mechanisms (Guo et al. 2023; Heredia et al. 2022; Huang et al. 2023).
Virtual Multi‐Phase Contrast Enhanced Liver MRI Using Deep Learning for Evaluating Hepatocellular Carcinoma
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description nbm70235-sup-0001-Supporting_Information.docxWord 2007 document , 2 MB Figure S1: Training loss curves for the generator and discriminator in each image-synthesis module.
B cells drive CD4 T cell immunosenescence and age-associated health decline
Editor’s summary Immunosenescence is the gradual age-associated decline in immune system function that renders older adults more susceptible to infection and disease. However, the mechanisms driving immunosenescence remain poorly understood. Khan et al. found that B cell–deficient mice maintain a CD4 T cell compartment that resists age-related decline and exhibit improved overall health, including an extended life span, compared with control mice.
Development and Validation of Six-Parameter Laboratory-Based Prognostic Model (APHPBA Score) for Patients Undergoing Hepatectomy for Hepatitis B Virus-Related Hepatocellular Carcinoma
Keywords Hepatocellular carcinoma Hepatitis B virus Biomarkers Prognostic model Laboratory medicine List of Abbreviations AFP (alpha-fetoprotein) ALB (albumin) ALP (alkaline phosphatase) ALT (alanine transaminase) APHPBA (AFP–PIVKA-II–HBV-DNA–PT–BIL–ALB) APRI (AST to Platelet Ratio Index) ASA (American Society of Anesthesiologists) AST (aspartate aminotransferase) AUC (area under the curve) BIL (bilirubin) BCLC (Barcelona Clinic Liver Cancer) CI (confidence interval) GGT (gamma-glutamyl...
Development and Validation of the APTNM Staging System: Integration of Serum Biomarkers with TNM Classification for Enhanced Prognostic Stratification Following Hepatectomy for Hepatocellular Carcinoma
Keywords Hepatocellular carcinoma Staging System Tumor-node-metastasis Alpha-fetoprotein Protein Induced by Vitamin K Absence or Antagonist-II Survival Recurrence List of Abbreviations AFP (alpha-fetoprotein) ASA (American Society of Anesthesiologists) AJCC (American Joint Committee on Cancer) AUROC (area under receiver operating characteristic curve) CI (confidence interval) ECOG (Eastern Cooperative Oncology Group) HBV (hepatitis B virus) HCC (hepatocellular carcinoma) HCV (hepatitis C...
Reliable Assessment of Healthcare Procedures: A Comparison of On-Site and Video-Based Methods
Back to Journals » Advances in Medical Education and Practice » Volume 17 Authors Yi M, Zhang Y, Wu F, Zhang S , Hu M, Liu C, Zheng B, Yang J Received 31 December 2025 Accepted for publication 1 April 2026 Published 13 April 2026 Volume 2026:17 592969 DOI https://doi.org/10.2147/AMEP.S592969 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Sateesh Arja Minghui Yi,1 Yao Zhang,2 Fei Wu,1 Shilong Zhang,3 Menghui Hu,1...
Adjusting Training Task Difficulty to Enhance Skill Transfer in Venipuncture: Evidence from Video Analysis
Jinling Yang,1 Minghui Yi,1 Fei Wu,1 Menghui Hu,1 Qinxi Yao,2 Hangdi Zhou,2 Ying Xiao,2 Yao Zhang,3 Yun Wu,3 Bin Zheng3 1Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 2School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 3Surgical Simulation Research Lab, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada...
Checkpointless training on Amazon SageMaker HyperPod: Production-scale training with faster fault recovery | Amazon Web Services
Artificial Intelligence Foundation model training has reached an inflection point where traditional checkpoint-based recovery methods are becoming a bottleneck to efficiency and cost-effectiveness. As models grow to trillions of parameters and training clusters expand to thousands of AI accelerators, even minor disruptions can result in significant costs and delays.
Decoupling Electrode Environments with a pH-Asymmetric Biphase Electrolyte for High-Voltage Aqueous Rocking-Chair Batteries
Cite Jump to ExpandCollapse Energy, Environmental, and Catalysis ApplicationsDecember 11, 2025 Decoupling Electrode Environments with a pH-Asymmetric Biphase Electrolyte for High-Voltage Aqueous Rocking-Chair Batteries Click to copy article linkArticle link copied! Fei Wu Fei Wu School of Materials Science and Engineering, Beihang University, Beijing 100191, China Le Yang Le Yang School of Materials Science and Engineering, Beihang University, Beijing 100191, China Qi Zhou Qi Zhou School of...
Risk Factors, Diagnostic Challenges, and Emerging Therapeutic Strategies for ICU-Acquired Weakness: A Brief Review
Abstract Intensive care unit-acquired weakness (ICU-AW) is a common complication in critically ill patients, associated with multiple risk factors and significantly impacting long-term patient outcomes.
Case Report: Pelvic splenosis confused with malignancy—a reminder for differential diagnosis
Abstract Background: Splenosis is a rare, benign disorder that arises after splenic trauma or splenectomy. Because its imaging features are nonspecific and often mimic those of malignant tumors, it is frequently misdiagnosed as malignant. The condition often presents without specific symptoms or elevated tumor markers, further complicating the diagnostic process.
Drug Resistance Patterns
Back to Journals » Infection and Drug Resistance » Volume 19 Authors Gao J, Wu F, Zhang Y, Wu J, Li W, Su N, Wang Y Received 27 September 2025 Accepted for publication 19 January 2026 Published 29 January 2026 Volume 2026:19 Pages 1—15 DOI https://doi.org/10.2147/IDR.S554982 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Oliver Planz Jingjing Gao,1,2 Fei Wu,3,4 Yuqiong Zhang,1,2 Jian Wu,1,2 Wenjing Li,1,2 Ning...
Research on Polar Motion Prediction Based on Radial Basis Function Neural Network Interpolation
1 Introduction Earth Orientation Parameters (EOP) are the main transformation parameters connecting the International Celestial Reference Frame and the International Terrestrial Reference Frame. EOP consist of precession, nutation, and Earth Rotation Parameters (ERP). ERP include Universal Time, Length of Day (LOD), Polar Motion (PM) and polar motion rates, which serve as essential variables for characterizing the variations in Earth's rotation.
Risk Factors and Intervention Strategies for ICU-Acquired Weakness: A | JMDH
Back to Journals » Journal of Multidisciplinary Healthcare » Volume 18 Authors Zhang X , Wang Z, Wang J, Wu F, Xia L, Shi S, Zhu M, Zhuang J Received 14 August 2025 Accepted for publication 4 November 2025 Published 28 November 2025 Volume 2025:18 Pages 7769—7778 DOI https://doi.org/10.2147/JMDH.S560139 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr David C.
Five Ways I Use ChatGPT as a Full-Time Creator to Get More Done
I've been a full-time creator for over ten years, so I'm always looking for ways to save time and use technology to make my life easier. One of my recent priorities has been to learn my way around ChatGPT and its many different use cases. Here, I'll share a few ways I'm using the chatbot in my everyday life. ChatGPT surpassed 400 million weekly active users earlier this year and is now one of the top ten most-visited websites in the world, according to SimilarWeb.
Risk Prediction Models of Subsyndromal Delirium in Critically Ill Patients: A Systematic Review and Meta‐Analysis
Data Availability Statement The datasets used and analysed during the current study are available from the corresponding author on reasonable request.
Anthropomorphic Head MRI Phantoms: Technical Development, Brain Imaging Applications, and Future Prospects
Compared to traditional phantoms, anthropomorphic head phantoms offer greater advantages in mimicking real human experimental scenarios. Thanks to continuous advancements in 3D printing technology and ongoing development of tissue-mimicking materials, significant achievements have been made in the production of anthropomorphic head phantoms. A comprehensive narrative review was conducted using Google Scholar as the primary database for literature retrieval.
Translution: Unifying Transformer and Convolution for Adaptive and Relative Modeling
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