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Articles by Giulia Protti
T cell–mediated depletion of intratumoral regulatory T cells using a CCR8xCD3 T cell–engaging bispecific antibody (TCB) promotes antitumor immunity in preclinical mouse models
Reference #1 Abstract Supplementary Materials REFERENCES AND NOTES eLetters (0) Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Abstract T cell–engaging bispecific antibodies (TCBs) have seen notable successes in hematologic malignancies, and emerging data demonstrate their potential for the treatment of solid tumors.
Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses
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ArticleOnline nowOpen access 1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 2Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 3Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA 4Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy 5Department of Pathology, University of Massachusetts Chan...
By Diana Castaño, Emily Bettini, Binod Kumar, Aleksey Chudnovskiy, Anna Siv, Giulia Protti, Sandra Nakadakari-Higa, Simona Ceglia, Nina De Luna, Joy E. Chiu, Katlyn Lederer, Shuk Hang Li, Hassaan Ibrahim, Hiromi Muramatsu, Thandiswa Mdluli, Edit Ábrahám, Ivan Maillard, Ying Tam, Scott Hensley Verified, Jonathan J. Miner, Zoltán Lipinszki, Andrea Reboldi, Norbert Pardi, Roberto Spreafico, Gabriel D. Victora, Michela Locci, Sinem E. Sahingur
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Cell Press
Verified
Distinct components of nucleoside-modified messenger RNA vaccines cooperate to instruct efficient germinal center responses
Abstract Nucleoside-modified mRNA vaccines elicit protective antibodies through their ability to promote T follicular helper (Tfh) cells. The lipid nanoparticle (LNP) component of mRNA vaccines possesses inherent adjuvant activity. However, to what extent the nucleoside-modified mRNA can be sensed and contribute to Tfh cell responses remains largely undefined. Herein, we deconvoluted the signals induced by LNP and mRNA that instruct dendritic cells (DCs) to promote Tfh cell differentiation.
Maturation signatures of conventional dendritic cell subtypes in COVID‐19 suggest direct viral sensing
Research Article|Basic Laura Marongiu, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy National Institute of Molecular Genetics “Romeo ed Enrica Invernizzi”, Milan, Italy Equal contribution Search for more papers by this author Giulia Protti, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy National Institute of Molecular Genetics “Romeo ed Enrica Invernizzi”, Milan, Italy Equal contribution Search for more papers...
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