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Articles

First-Line Serplulimab in Extensive-Stage Small Cell Lung Cancer : Secondary Analysis of the ASTRUM-005 Phase 3 Randomized Clinical Trial

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By Jingjing Liu, Lin Wu, Jun Chen, Hongmei Sun, Guilan Wen, Yinghua Ji, Jianhua Shi, Zhijie Pan, Jinsheng Shi, Xicheng Wang, Yuansong Bai, Yueyin Pan, Xuhong Min, Maksym Viguro, Xingya Li, Yanqiu Zhao, Junquan Yang, Tamta Makharadze, Ekaterine Arkania, HAOYU YU, Jing Li, Xinyi Yang, Qingyu Wang, Jun Zhu, Ahmet Bilici, Aihong Zhong, Alexandre Tavartkiladze, Bangwei Cao, Chun Liang Chen, Davit Giorgadze, Denys Pominchuk, Devrim Cabuk, Dongji Chen, Fedor Moiseenko, Feng Luo, Gaofeng Li, Gongyan Chen, Guangyu An, Guoping Sun, Guosheng Feng, Yanrong Song, Haixin Huang, Hakan Harputluoglu, Hao Xiong, Hui Zhao, Igor Bondarenko, Irfan Cicin, Ivan Sinelnikov, Jian Fang, Jiuwei Cui, Junguo Lu, Kejing Ying, Konstantin Penkov, Liqin Lu, Liyan Jiang, Lu Yue, Mahmut Gümüş, Mehmet Artaç, Mengzhao Wang, Min Fan, Mustafa Özgüroğlu, Peiguo Cao, Peiyan Zhao, Ping Sun, Robert M. Mróz, Sergey Orlov, Shuang Zhang, Shuqun Zhang, Tao Zhang, Tuncay Göksel, Wen Lin, Wenlei Zhuo, Xiaoli Zhu, Xiubao Ren, Yan Wang, Yanping Hu, Yarong Li, Ying Cheng, Yuksel Urun, Zhendong Chen, Zhenyu You, Zhixiong Yang, Zhong Lin, Zhuang Yu, Alev Türker, Amiran Matitashvili, Andrey Akopov, Andrii Gardashnikov, Cagatay Arslan, Eugeny Kulikov, Igor Lifirenko, Ligong Nie, Malgorzata Ulanska, Maria Smagina, Mariam Zhvania, Nadezhda Kovalenko, Oleg Kobziev, Oleksii Kolesnik, Olexandr Goloborodko, Sergey Cheporov, Shenpeng Ying, Tariel Kitiashvili, Timur Andabekov, Tsira Kortua, Vadim Shirinkin, Vladimer Kuchava, Yevhen Hotko, Yuriy Semegen
| JAMA Oncology Verified
First-Line Serplulimab in Extensive-Stage Small Cell Lung Cancer: Secondary Analysis of the ASTRUM-005 Phase 3 Randomized Clinical Trial Key Points Question What are the long-term efficacy and safety outcomes of adding serplulimab to first-line chemotherapy for previously untreated extensive-stage small cell lung cancer (ES-SCLC)?
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Toward sustainable food preservatives: high-level production of sorbic acid in engineered Saccharomyces cerevisiae

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By Jianbin Xiao, Wei Lin, Xingtong Chen, HAOYU YU, Chao Chen, Qin Li, Fan Cai, Huaidong Zhang, Huibin Chen, Mingliang Zhang, Yongjin J. Zhou
| Nature Verified
Abstract Sorbic acid (SA) and its salts are among the world’s most widely used and safest food preservatives, yet their industrial production still relies on fossil fuel-derived feedstocks via chemical synthesis. Here, we report bioproduction of SA through microbial fermentation by decoding its biosynthetic pathway and metabolic engineering of Saccharomyces cerevisiae as a chassis. Here, we identify SA and its amide derivative sorbamide (SN) from Myrothecium sp.
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