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Yueyin Pan

As seen in: Nature, The BMJ, JAMA (The Journal of the American Medical Association), JAMA Oncology, JAMA: Journal of the American Medical Association, The Lancet, Lung Cancer
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Articles

First-Line Serplulimab in Extensive-Stage Small Cell Lung Cancer : Secondary Analysis of the ASTRUM-005 Phase 3 Randomized Clinical Trial

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By Jingjing Liu, Lin Wu, Jun Chen, Hongmei Sun, Guilan Wen, Yinghua Ji, Jianhua Shi, Zhijie Pan, Jinsheng Shi, Xicheng Wang, Yuansong Bai, Yueyin Pan, Xuhong Min, Maksym Viguro, Xingya Li, Yanqiu Zhao, Junquan Yang, Tamta Makharadze, Ekaterine Arkania, HAOYU YU, Jing Li, Xinyi Yang, Qingyu Wang, Jun Zhu, Ahmet Bilici, Aihong Zhong, Alexandre Tavartkiladze, Bangwei Cao, Chun Liang Chen, Davit Giorgadze, Denys Pominchuk, Devrim Cabuk, Dongji Chen, Fedor Moiseenko, Feng Luo, Gaofeng Li, Gongyan Chen, Guangyu An, Guoping Sun, Guosheng Feng, Yanrong Song, Haixin Huang, Hakan Harputluoglu, Hao Xiong, Hui Zhao, Igor Bondarenko, Irfan Cicin, Ivan Sinelnikov, Jian Fang, Jiuwei Cui, Junguo Lu, Kejing Ying, Konstantin Penkov, Liqin Lu, Liyan Jiang, Lu Yue, Mahmut Gümüş, Mehmet Artaç, Mengzhao Wang, Min Fan, Mustafa Özgüroğlu, Peiguo Cao, Peiyan Zhao, Ping Sun, Robert M. Mróz, Sergey Orlov, Shuang Zhang, Shuqun Zhang, Tao Zhang, Tuncay Göksel, Wen Lin, Wenlei Zhuo, Xiaoli Zhu, Xiubao Ren, Yan Wang, Yanping Hu, Yarong Li, Ying Cheng, Yuksel Urun, Zhendong Chen, Zhenyu You, Zhixiong Yang, Zhong Lin, Zhuang Yu, Alev Türker, Amiran Matitashvili, Andrey Akopov, Andrii Gardashnikov, Cagatay Arslan, Eugeny Kulikov, Igor Lifirenko, Ligong Nie, Malgorzata Ulanska, Maria Smagina, Mariam Zhvania, Nadezhda Kovalenko, Oleg Kobziev, Oleksii Kolesnik, Olexandr Goloborodko, Sergey Cheporov, Shenpeng Ying, Tariel Kitiashvili, Timur Andabekov, Tsira Kortua, Vadim Shirinkin, Vladimer Kuchava, Yevhen Hotko, Yuriy Semegen
| JAMA Oncology Verified
First-Line Serplulimab in Extensive-Stage Small Cell Lung Cancer: Secondary Analysis of the ASTRUM-005 Phase 3 Randomized Clinical Trial Key Points Question What are the long-term efficacy and safety outcomes of adding serplulimab to first-line chemotherapy for previously untreated extensive-stage small cell lung cancer (ES-SCLC)?
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Savolitinib in MET -amplified gastric or gastroesophageal junction adenocarcinoma: a phase 2 trial

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By Zhi Peng, Tianshu Liu, Hua Wang, Jufeng Wang, Hongli Liu, Feng Ye, Enxiao Li, Jun Zhang, Baorui Liu, Rongbo Lin, Aiping Zhou, Zhenyang Liu, Huiting Xu, Qiong Wang, Zuoxing Niu, Ying Yuan, Yanru Qin, Xiujuan Qu, Yuxian Bai, Ning Liu, Hailong Liu, Chunmei Bai, Yueyin Pan, Shubin Wang, Tao Wu, Qinghua Pan, Diansheng Zhong, Hongxia Lu, Junye Wang, Zhiyu Wang, Ting Deng, Hongfeng Gou, Xiwen Huang, Puhan Lu, Jie Yu, qian Xu, Linfang Wang, Yongxin Ren, Songhua Fan, Lin Shen, Mengyang Hong
| Nature Verified
Abstract MET proto-oncogene amplification (METamp) is associated with poor prognosis in gastric or gastroesophageal junction (G/GEJ) cancer. Currently, effective targeted therapies for G/GEJ cancer harboring METamp remain unavailable, and clinical evidence supporting the use of MET inhibitors in this disease population is limited. Here we report the results of a phase 2 study of savolitinib, an oral MET inhibitor, in patients with METamp G/GEJ cancer.
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BRD4 orchestrates the metabolic-epigenetic regulation of GM-CSF expression and secretion to drive PD-L1⁺ macrophage-mediated immune evasion in triple-negative breast cancer | Oncogene

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By Haizhou Diao, Yan Zhang, Hui Hua, Menghao Dong, Wei Jin, Jian Chen, Benjie Shan, Xinghua Han, Xiuwei Yang, Yueyin Pan, Jinguo Zhang, Jingxiong Chen, Yueyue Cao
| Nature Verified
Abstract Immune checkpoint blockade targeting the PD-1/PD-L1 axis shows promise in triple-negative breast cancer (TNBC), yet durable responses are limited by immune escape. Here, we identified tumor-derived bromodomain-containing protein 4 (BRD4) as a critical mediator of tumor-associated macrophage (TAMs)-driven immune evasion in TNBC. Using syngeneic TNBC mouse models, we found that BRD4 promotes PD-L1 expression on TAMs by increasing GM-CSF production from tumor cells.
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