Yinghua Ji
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First-Line Serplulimab in Extensive-Stage Small Cell Lung Cancer : Secondary Analysis of the ASTRUM-005 Phase 3 Randomized Clinical Trial
First-Line Serplulimab in Extensive-Stage Small Cell Lung Cancer: Secondary Analysis of the ASTRUM-005 Phase 3 Randomized Clinical Trial Key Points Question What are the long-term efficacy and safety outcomes of adding serplulimab to first-line chemotherapy for previously untreated extensive-stage small cell lung cancer (ES-SCLC)?
Editing strigolactone hormone receptor for robust antiviral silencing in rice
Keywords strigolactones DWARF14 RNA silencing plant antiviral immunity Introduction Strigolactones (SLs) are one of the key phytohormones that regulate plant growth and development by triggering transcriptional repressor degradation to activate target gene transcription.1,2,3,4,5,6,7,8 The biosynthesis of SLs from carotenoids is mediated by a series of enzymes, such as β-carotene cis-trans isomerase DWARF27 (D27) and carotenoid cleavage dioxygenases DWARF17 (D17) and DWARF10 (D10) in rice...
Case Report: Anlotinib combined with radiotherapy achieves sustained disease control in advanced malignant melanotic nerve sheath tumor
1 Introduction Malignant melanotic nerve sheath tumors (MMNSTs), previously referred to as melanotic schwannomas (MS), are exceptionally rare neoplasms accounting for less than 1% of primary peripheral nerve sheath tumors (1). These tumors exhibit a slightly higher prevalence among females, with a reported female-to-male ratio of 1.4:1 (2).
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