Heather Harding
As seen in:
Nature,
Education Week,
BioRxiv,
Cell Press,
Cell Reports,
eLife,
The Hechinger Report,
Education Next,
The 74,
Ed Post
and
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Heather Harding
A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response
Abstract Eukaryotic initiation factor 2B (eIF2B), a guanine nucleotide exchange factor (GEF), promotes protein synthesis by charging translation initiation factor 2 (eIF2) with GTP. Stress-induced phosphorylation of eIF2 on its α-subunit [eIF2(αP)] inhibits this reaction triggering a protective Integrated Stress Response (ISR).
I Fought for Public Education. What I Learned From Its Detractors
In October 2021, the Campaign for our Shared Future was launched by two education advocates who recognized that politicians were waging war on public education and public educators for political gain. The campaign was designed as a nonpartisan, time-bound effort to defend and promote high-quality public education addressing the needs of all children and promising an accurate telling of United States history.
A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
eLife assessment In this important study, the authors explore ER stress signaling mediated by ATF6 using a genome-wide gene depletion screen. They find that the ER chaperone Calreticulin binds and directly represses ATF6, a new and intriguing function for Calreticulin. The evidence presented is convincing, based on CHO genetics and biochemical analysis.
A genome wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
Abstract Activating transcription factor 6 (ATF6) is one of three endoplasmic reticulum (ER) transmembrane stress sensors that mediate the unfolded protein response (UPR). Despite its crucial role in long-term ER stress adaptation, regulation of ATF6⍺ signalling remains poorly understood, possibly because its activation involves ER to Golgi and nuclear trafficking.
A genome wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6⍺
Abstract Activating transcription factor 6 (ATF6) is one of three endoplasmic reticulum (ER) transmembrane stress sensors that mediate the unfolded protein response (UPR). Despite its crucial role in long-term ER stress adaptation, regulation of ATF6 alpha (⍺) signalling remains poorly understood, possibly because its activation involves ER to Golgi and nuclear trafficking.
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the Integrated Stress Response
Abstract Dephosphorylation of pSer51 of the α subunit of translation initiation factor 2 (eIF2αP) terminates signalling in the integrated stress response (ISR). A trimeric mammalian holophosphatase comprised of a PP1 catalytic subunit, the conserved C-terminally located ~70 amino acid core of a substrate-specific regulatory subunit (PPP1R15A/GADD34 or PPP1R15B/CReP) and G-actin (an essential co-factor) efficiently dephosphorylate eIF2αP in vitro.
Parents and Teachers Agree: Kids Need Strong Public Schools - Not Culture Wars
This November, voters taught America a valuable lesson: People across the country want high-quality, well-resourced public schools that are safe and welcoming for all children — and they’re ready to turn out to vote for it. Despite with culture war rhetoric, candidates who favor student-centered policies that strengthen public education won up and down the ballot. The message is clear: Public schools serve as the anchor of our communities.
A legacy of safety and efficiency
Pulp and paper mills rely on functioning, quality refractory to keep the plant up and running. These operations’ worst nightmare is unplanned downtime and maintenance. One singular shutdown can cost mills thousands of dollars a day in lost production, especially for a facility that is producing more than three hundred thousand tons of pulp and paper per year. One mill in Terrace Bay, Ontario, faced a refractory failure just one year after a fresh installation.
The benefits of utilizing safety cages to protect against falling debris
Worksite safety plays a big role in refractories, mines, construction worksites and a number of other operations. According to the U.S. Bureau of Labor Statistics, up to 50,000 workers were injured in 2020 when struck by falling debris. Additionally, between 2016 and 2020, there were 1,228 recorded fatalities due to the same safety hazard. Instances that don’t result in major injury or fatality often go unrecorded, which means the true numbers could be – and likely are – much higher.
How to Minimize TCO for Bricking Machines
When looking to buy equipment for refractory maintenance, it can be tempting to choose the low-est-cost option or to make due with a bricking machine that is offered complimentary with brick. After all, the bricking machine has a dedicated and limited purpose and is not used daily. That raises the question: Why invest in a premium product for occasional use? Minimizing the initial investment may seem like the way to go.
Smart Kiln Maintenance
Refractory Maintenance Is Unavoidable, But An Experienced Crew With The Right Equipment Can Minimize Scheduled Downtime And Virtually Eliminate Installation Mistakes That Could Lead To Emergency Maintenance. By Heather Harding Time is money. No place is this adage more appropriate than the manufacturing industry.
Children Paying the Price for Culture Wars and Witch Hunts in Public Education
Personal attacks on educators and others working in public education by political extremists have become all too common in recent years — and our children are paying the price. Our children are being used as pawns in the politically motivated culture wars being forced into our nation’s public schools, and it’s time for this to stop. Remember these stories?
OPINION: Our children are paying the price for the culture wars and witch hunts in public education
Personal attacks on educators and others working in public education by political extremists have become all too common in recent years — and our children are paying the price. Our children are being used as pawns in the politically motivated culture wars being forced into our nation’s public schools, and it’s time for this to stop. Remember these stories?
Revolutionizing Refractory Maintenance
Refractory maintenance, though vital, can often be a logistical and financial burden. This is especially true for large facilities that rely on kilns, coolers, preheater towers and risers for day-to-day operation. These facilities stand to lose upward of $50,000 a day in production if their refractory can’t stand up to the heat. To avoid unnecessary production loss, most facilities take on large-scale refractory removal and re-installation during annual maintenance shutdowns.
Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers
Highlights • Genome-wide CRISPR screen for genes affecting trafficking of polymerogenic α1AT • CRISPR enrichment based on recovery of DNA from phenotypic selected fixed cells • Early secretory pathway as the strongest modifier of α1AT intracellular polymers • LMAN1 and SURF4 regulate the export of monomeric and polymeric α1AT out of the ER Summary Circulating polymers of α1-antitrypsin (α1AT) are neutrophil chemo-attractants and contribute to inflammation, yet cellular factors affecting their...
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B
Highlights • Mutually antagonistic binding of phosphorylated eIF2 and ISRIB to eIF2B • Opposing structural rearrangement of eIF2B by binding ISRIB or phosphorylated eIF2 • Phosphorylated eIF2 exposes ISRIB’s ability to enhance eIF2B activity in vitro • Weak ISR-inhibitory activity of ISRIB in cells lacking phosphorylated eIF2 Summary The small molecule ISRIB antagonizes the activation of the integrated stress response (ISR) by phosphorylated translation initiation factor 2, eIF2(αP).
Voters urged to cast ballots early absentee for May town elections
News Weather | Virginia News | Halifax | Mecklenburg Voters urged to cast ballots early absentee for May town elections SoVaNow.com / March 19, 2020 By Heather Harding Director of Elections-Halifax County The Halifax County Voter Registration encourages voters to protect their health during COVID-19 outbreak. Voting absentee in the coming local May elections is strongly encouraged. Voters may choose reason “2A my disability or illness” for Absentee voting in the May 2020 elections due to COVID-19.
High-Temperature Refractory Maintenance
From brick tear-out to installation, there are a lot of opportunities for safety, efficiency and cost savings to fall through the cracks during kiln maintenance. Whether the challenge rests with plant personnel or a subcontractor, planning ahead and having the right equipment can prove both beneficial and profitable.
An Open Letter to My Ed School Dean
Last month, Emily Hanford of American Public Media filed a withering indictment of reading instruction in U.S. schools. Her radio documentary, “Hard Words,” exposed how much “decades of scientific research” have taught us about reading—and how little of it has reached classroom practice via teacher training.
Becoming an Instructional Coach - Education Next
There’s a lot out there these days on coaching as a strategy for professional learning and teacher leadership—particularly as a vehicle for enhancing the trajectory of a teaching career. Leveraging the expertise of a great teacher makes sense for supporting ongoing learning for all teachers and improving instruction for students.
Has TFA Lost Its Way? No - It Is Evolving to Meet the Needs of Its Recruits & the Students They Teach
Recently, I got teary-eyed listening to Wendy Kopp tell the story of Teach For America on Guy Raz’s podcast How I Built This on NPR. Essentially, it reminded me of the moment when I read about Teach For America and Kopp in Newsweek magazine, July 1990. It told the story of a Princeton grad who was launching a national teacher corps by sending recruiters to top university campuses and placing those idealistic, talented undergrads to teach in the nation’s neediest schools. I was sold.
Rick Hess Straight Up
I got a number of notes regarding yesterday's post, mostly either dinging me for my concerns about value-added systems or asking how I can raise such concerns and still write, "Value-added does tell us something useful and I'm in favor of integrating it into evaluation and pay decisions, accordingly." Let me clarify. I think that two things are both true: First, teachers vary widely in ability and performance, and many people teaching today probably shouldn't be.
Rick Hess Straight Up
So, I'll be at AERA for the next few days. Planning against the possibility that I'm going to be taken into custody or forced into an undisclosed location by a cabal of irate edu-colleagues, my "plan-for-the-worst" assistant Daniel Lautzenheiser suggested we turn RHSU over to guest bloggers for the next few weeks. You know, just in case... Once again, we've lined up guest bloggers who are all more knowledgeable and interesting than yours truly.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Heather
Contact Heather, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack