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ArticleVolume 86, Issue 14p2811-2827.e10Open access Affiliations & Notes 1Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, 92093, United States of America 2Sanford Stem Cell Institution Innovation Center, Stem Cell Program, University of California, San Diego, La Jolla, CA, 92037, United States of America 3Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, 92093, United States of America 4Bioinformatics and...
Abstract The brain displays the richest repertoire of post-transcriptional mechanisms regulating mRNA translation1,2,3,4,5,6,7,8,9,10,11. Among these, alternative splicing has been shown to drive cell-type specificity and, when disrupted, is strongly linked to neurological disorders12,13,14,15,16,17. However, genome-wide measurements of mRNA translation with isoform sensitivity at single-cell resolution have not been achieved.
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