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ArticleVolume 86, Issue 14p2811-2827.e10Open access Affiliations & Notes 1Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, 92093, United States of America 2Sanford Stem Cell Institution Innovation Center, Stem Cell Program, University of California, San Diego, La Jolla, CA, 92037, United States of America 3Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, 92093, United States of America 4Bioinformatics and...
Abstract Effective scar control requires selectively suppressing late-stage fibrosis without compromising early wound closure. We developed a localized, time-staged delivery system. A poly-(HA-GMA) hydrogel serves as a short-term depot, loaded with AAV8-sTβRII and applied directly along the wound margin. Materials characterization showed a water-rich porous network that rapidly imbibes and releases vector primarily by diffusion.
We first designed a pool of 2059 variants spanning 110 exons with reference, consensus splice site, and mutated splice site control sequences for each exon. To ensure reproducibility, each variant exon was associated with at least three unique eight-nucleotide barcodes. Common primer sequences and restriction enzyme sites were also added for proper library construction.
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