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Articles by Jee Park
Hypertensive Disorders of Pregnancy and Incident Dementia
Supplement 1. eTable 1. ICD-10 Code for Delivery-Related Procedure eTable 2. ICD-10 Codes for Dementia eTable 3. ICD-10 Codes for Hypertensive Disorder During Pregnancy and Other Diseases eFigure. Schematic Diagram of Proposed Mechanisms Linking Hypertensive Disorders of Pregnancy to later-Life Dementia Supplement 2. Figure 1.
Oxygen-dependent subcellular redistribution of PHD3 links the hypoxic microenvironment to mitochondrial metabolic reprogramming in ccRCC
Abstract Clear cell renal cell carcinoma (ccRCC) is characterized by profound metabolic dysregulation, with both prolyl hydroxylase domain protein 3 (PHD3) and pyruvate carboxylase (PC) independently implicated in disease progression. Although each influences patient outcomes, a direct mechanistic interplay between these two regulators has remained elusive.
Needle-Free Prediction of Fetal Lung Maturity Using Vaginal Fluid Extracellular Vesicles
Unanticipated respiratory morbidity remains a critical challenge in late preterm and early-term pregnancies, often transforming a seemingly low-risk delivery into a medical crisis requiring neonatal intensive care unit (NICU) admission.1-3 Current clinical practice relies heavily on gestational age (GA) as a proxy for fetal lung maturity because amniocentesis is invasive, although GA is an imprecise surrogate for functional respiratory competence.
Modeling single nucleus microglia across species identifies immune pathways and therapeutic candidates in Alzheimer’s disease
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by memory loss and behavioral changes. A pivotal influence on AD pathology is the dysregulation of microglia in the brain. Despite promising findings in mouse models, there are limitations to the translatable biological information across species due to differences in the physiology, timeline of disease, and human heterogeneity.
Single-photon emission from two-dimensional perovskites channeled through low-energy edge states
Abstract Two-dimensional perovskites, an emerging family of van der Waals materials with an innate quantum-well structure, exhibit remarkable optical characteristics and compositional tunability. However, their potential as a source for quantum emitters remains unexplored. Here, we investigate low-energy edge states unique to two-dimensional perovskites using comprehensive photoluminescence imaging and spectroscopy, to further leverage them towards uncovering quantum emitters.
Guest Column: Raymond Flanks case reminds us that rights of the innocent don’t end when they become inconvenient Original
It is a fact that innocent people are wrongfully convicted and imprisoned. Louisiana recognizes this and provides wrongfully convicted individuals the right to appear in court and petition for justice and freedom. This right must be upheld and protected even as political winds shift and politicians shift with them.
Non-Contact Acoustic Emission Detection of External Rail Defects Using Air-Coupled Sensors
1. Introduction In railroad transportation, rail and wheels directly interact as trains move. The rails experience wear and tear during daily operations, leading to both internal and external defects over time. As part of defect detection efforts, various inspection and detection technologies, including imaging and ultrasound detection, have been applied to monitor rail surface health conditions.
Impact of β3‐adrenergic receptor agonist on kidney cancer risk in patients with overactive bladder
Data Availability Statement The nationwide cohort dataset is available from the National Health Insurance Sharing Service (NHISS) (https://nhiss.nhis.or.kr). The NHISS allows access to all these data for any researcher who promises to follow research ethics at some cost. If you want to access the data from this study, you can download it from the website after promising to follow the research ethics. Data release by the researcher is not legally permitted.
Mouse-to-human modeling of microglia single-nuclei transcriptomics identifies immune signaling pathways and potential therapeutic candidates associated with Alzheimer's disease
Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory loss and behavior change. Studies have found that dysregulation of microglial cells is pivotal to AD pathology. These mechanisms have been studied in mouse models to uncover potential therapeutic biomarkers.
A case report of successful vaginal delivery for cauda equina syndrome
Introduction Cauda equina syndrome (CES) and complex regional pain syndrome (CRPS) are both very rare disease entities that affect the quality of life.
Comparison of body composition change, measured with bioelectrical impedance analysis, between singleton and twin pregnancy: A prospective cohort study
Abbreviations BIA (bioelectrical impedance analysis) BMI (body mass index) DM (diabetes mellitus) ECW (extracellular water) ICW (intracellular water) PPROM (preterm premature rupture of membranes) TBW (total body water) Keywords Bioelectrical impedance analysis Body composition Water retention Twin pregnancy Body mass index Fat Get full text access Log in, subscribe or purchase for full access. References 1.
Evaluation of On-Vehicle Bone-Conduct Acoustic Emission Detection for Rail Defects
Evaluation of On-Vehicle Bone-Conduct Acoustic Emission Detection for Rail Defects () Lei Jia1, Jee Woong Park1, Ming Zhu2, Yingtao Jiang2, Hualiang Teng1 1Department of Civil and Environmental Engineering and Construction, University of Nevada, Las Vegas, NV, USA. 2Department of Electrical and Computer Engineering, University of Nevada, Las Vegas, NV, USA.
176 Immunological impact of cytoreductive nephrectomy in combination with immune checkpoint inhibitors in metastatic renal cell carcinoma: insights from the SEVURO-CN trial | Journal for ImmunoTherapy of Cancer
Abstract Background The role of cytoreductive nephrectomy (CN) in the treatment of metastatic renal cell carcinoma (mRCC) remains unclear in the immuno-oncology (IO) era. Currently, only two clinical trials PROBE (NCT04510597) and NORDICSUN (NCT03977571), are investigating the role of deferred CN versus no CN. Since neither trial has included an upfront CN arm, we designed SEVURO-CN trial, which compares upfront CN, deferred CN, and no CN.
Moiré superlattices in twisted two-dimensional halide perovskites - Nature Materials
Abstract Moiré superlattices have emerged as a new platform for studying strongly correlated quantum phenomena, but these systems have been largely limited to van der Waals layer two-dimensional materials. Here we introduce moiré superlattices leveraging ultrathin, ligand-free halide perovskites, facilitated by ionic interactions. Square moiré superlattices with varying periodic lengths are clearly visualized through high-resolution transmission electron microscopy.
Exosomal miRNAs from maternal vaginal discharge as biomarkers for preterm labor: non-invasive liquid biopsy
The authors have declared no competing interest. This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (2022R1A2C1093134) and the Creative-Pioneering Researchers Program through Seoul National University (800-20230492). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Semi-quantitative metalloproteinase-8 rapid test for the prediction of adverse pregnancy outcomes in patients with preterm premature rupture of membranes
Preterm prelabor rupture of the membranes: a disease of the fetal membranes. Semin Perinatol. 2017; 41: 409-419 Romero R. Espinoza J. Kusanovic J.P. et al. The preterm parturition syndrome. BJOG. 2006; 113: 17-42 Romero R. Espinoza J. Gonçalves L.F. Kusanovic J.P. Friel L. Hassan S. The role of inflammation and infection in preterm birth. Semin Reprod Med. 2007; 25: 21-39 Wu Y.W. Colford Jr., J.M. Chorioamnionitis as a risk factor for cerebral palsy: a meta-analysis. JAMA.
ctDNA predicts clinical T1a to pathological T3a upstaging after partial nephrectomy
cc clear cell cT1a clinical stage T1a ctDNA circulating tumor DNA EAU European Association of Urology PFI perinephric fat invasion PN partial nephrectomy pT3a pathological stage T3a RCC renal cell carcinoma RN radical nephrectomy SFI sinus fat invasion TE tumor enucleation 1 INTRODUCTION As imaging examinations have advanced dramatically in recent years,1 most patients diagnosed with ccRCC are incidentally identified as having small and organ-confined tumors.2 The vast majority of these newly...
Harry Connick: A legacy of injustice
Last week, Harry Connick Sr. died at age 97. For 30 years of his life, he was the elected district attorney of Orleans Parish. In this professional role, he had ultimate responsibility for what the prosecutors on his staff did. His staff repeatedly sent innocent people to prison or to death row. The National Registry of Exonerations reports that New Orleans has the highest wrongful conviction rate in the country. It reports 32 recognized exonerations of people prosecuted by Connick’s office.
Thickness control of organic semiconductor-incorporated perovskites - Nature Chemistry
Abstract Two-dimensional organic semiconductor-incorporated perovskites are a promising family of hybrid materials for optoelectronic applications, owing in part to their inherent quantum well architecture. Tuning their structures and properties for specific properties, however, has remained challenging. Here we report a general method to tune the dimensionality of phase-pure organic semiconductor-incorporated perovskite single crystals during their synthesis, by judicious choice of solvent.
Exploring the Characteristics of Circulating Tumor DNA in Pt1a Clear Cell Renal Cell Carcinoma: A Pilot Study
Open AccessArticle by Hongkyung Kim 1,†, Jee Soo Park 2,3,†, Zisun Choi 4, Seungki Min 4, Jihyang Park 4, Saeam Shin 5, Jong Rak Choi 4,5, Seung-Tae Lee 4,5,* and Won Sik Ham 2,* 1 Department of Laboratory Medicine, Chung-Ang University Gwangmyung Hospital, Chung-Ang University College of Medicine, Gwangmyung 14353, Republic of Korea 2 Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Severance Hospital, Seoul 03722, Republic of Korea 3 Department...
Dimensionality Engineering of Lead Organic Chalcogenide Semiconductors
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2023, XXXX, XXX CCDC 2266800, 2266802, 2266804, and 2291655 contain the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/data_request/cif, or by emailing data_request@ccdc.cam.ac.uk, or by contacting The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: +44 1223 336033.
Guest column: Justice demands we better track bad police officers Original
Police impunity and lack of law enforcement accountability has been highlighted in a series of investigative articles by The Times-Picayune | The Advocate and Nola.com in the special report Sworn & Protected. The stories report that at least 228 police officers in the last decade were convicted of crimes involving violence, harassment, sexual assault, malfeasance, dishonesty and theft, and yet only 1 in 5 have lost their credentials to continue working in law enforcement.
Emerging Two-Dimensional Organic Semiconductor-Incorporated Perovskites─A Fascinating Family of Hybrid Electronic Materials
Halide perovskites have attracted a great amount of attention owing to their unique materials chemistry, excellent electronic properties, and low-cost manufacturing. Two-dimensional (2D) halide perovskites, originating from three-dimensional (3D) perovskite structures, are structurally more diverse and therefore create functional possibilities beyond 3D perovskites.
Suppressing phase disproportionation in quasi-2D perovskite light-emitting diodes - Nature Communications
Chemicals and reagents Organic solvents, including anhydrous N,N-dimethylformide (DMF), chlorobenzene (CB), ethanol, and solid chemicals, including lead iodide (PbI2), Poly-TPD, PVP (Mw = 29 k, 40 k, 360 k, 1300 k), potassium acetate (KAc), formamidinesulfinic acid (FSA), muconic acid, 1,3,5-tris(1-phenyl-1H-benzimidazol-2-yl)benzene (TPBi), LiF were purchased from Sigma Aldrich.
Feasibility of Using a Factory-Calibrated Continuous Glucose Monitoring System to Diagnose Type 2 Diabetes
Diabetes Technology & TherapeuticsAhead of Print Original ArticleFree Access Abstract Context: Plasma glucose or A1C criteria can be used to establish the diagnosis of type 2 diabetes (T2D). Objective: We examined whether continuous glucose monitoring (CGM) data from a single 10-day wear period could form the basis of an alternative diagnostic test for T2D.
Development of prediction models of spontaneous ureteral stone passage through machine learning: Comparison with conventional statistical analysis
Loading metrics Open Access Peer-reviewed Research Article Jee Soo Park , Dong Wook Kim , Dongu Lee, Taeju Lee, Kyo Chul Koo, Woong Kyu Han, Byung Ha Chung, Kwang Suk Lee Jee Soo Park, Dong Wook Kim, Dongu Lee, Taeju Lee, Kyo Chul Koo, Woong Kyu Han, Byung Ha Chung, Kwang Suk Lee Published: December 1, 2021 https://doi.org/10.1371/journal.pone.0260517 Figures Abstract Objectives To develop a prediction model of spontaneous ureteral stone passage (SSP) using machine learning and logistic...
A new scoring and staging system for acute cervical insufficiency based on physical and sonographic examination
Abstract Objectives Acute cervical insufficiency accounts for 10-25% of all mid-trimester pregnancy losses. However, the definition and description for degree of acute cervical insufficiency were obscure and different among the many studies. The aim of this study was to suggest a new 4-digit diagnostic system and evaluate the outcome according to the new system in women with acute cervical insufficiency.
From Textbook Pluralism to Modern Hyper-Pluralism: Interest Groups and Supreme Court Nominations, 1930-2017
Jonathan P. Kastellec, Charles Cameron, Cody Gray, and Jee Kwang Park ACCEPTED: February 11, 2020
Efficacy and safety of mirabegron, a β3-adrenoceptor agonist, for treating neurogenic bladder in pediatric patients with spina bifida: a retrospective pilot study
Original Article First Online: 03 December 2018 102 Downloads Abstract Purpose Antimuscarinics are the first pharmacological treatment option for neurogenic bladder in children with spina bifida but side effects limit their use. Mirabegron, a new β-3 adrenoceptor agonist with a distinct mechanism of action, is a potential agent for the treatment of neurogenic bladder; however, it has yet to be studied in the pediatric population.
Transurethral incision as initial option in treatment guidelines for ectopic ureteroceles associated with duplex systems
Authors Authors and affiliations Jee Soo Park Yong Seung Lee Cho Nyeong Lee Sung Hoon Kim Sang Woon Kim Hyeyoung Lee Sang Won Han Original Article First Online: 02 January 2019 Abstract Purpose Treatment strategies for children with ectopic ureteroceles (EUs) and duplex collecting systems or vesicoureteral reflux are controversial. Transurethral incision (TUI) of EUs associated with duplex systems has been considered only as a temporizing technique.
Guest column: Eyewitness testimony can be flawed
Three men. Each innocent. They spent more than 58 years in prison for crimes they did not commit. Malcolm Alexander, 37 years, 10 months. Michael Shannon, 10 years, 8 months. Kia Stewart, 10 years.On February 11, 2018, the murder charge against Michael Shannon was dismissed and the Orleans Parish District Attorney stated that “in all likelihood” he is innocent.
Caffeine consumption disrupts hippocampal long‐term potentiation in freely behaving rats
Caffeine, one of the most commonly consumed psychoactive substances in the world, has long been known to alter neurological functions, such as alertness, attention, and memory. Despite caffeine's popularity, systematic investigations of its effects on synaptic plasticity in the brain are still lacking.
Identification of the In Vivo Pharmacokinetics and Pharmacodynamic Driver of Iclaprim
The neutropenic murine thigh infection model was used to define the pharmacokinetic/pharmacodynamic index linked to efficacy of iclaprim against Staphylococcus aureus ATCC 29213 and Staphylococcus pneumoniae ATCC 10813. The 24-h area under the curve (AUC)/MIC index was most closely linked to efficacy for S.
Development of a Novel Preclinical Model Based on HLA-A2 Transgenic Mice to Evaluate T-Cell Receptor Mimic Monoclonal Antibodies as Therapeutic Agent against Brain Metastases of Human Breast Cancer
The HLA-A2 restricted T-cell receptor mimic (TCRm) antibody RL6A has been shown to have antitumor effects in a breast cancer orthotopic xenograft model with MDA-MB-231 cells. Transgenic mice expressing HLA-A2 also take up RL6A into brain across the blood-brain barrier (BBB). The present study evaluates different approaches to obtain a reliable brain tumor model using HLA-A2 transgenic mice, in which pharmacokinetics and antitumor efficacy of RL6A on brain metastasis could be studied.
Internalization of T-Cell Receptor Mimic Antibody RL6A by Brain Derived Endothelial Cells Analyzed by Flow Cytometry
T-cell receptor mimic monoclonal antibodies (TCRm) recognize peptide-MHC class I complexes. They combine the specificity of T-cell receptors with high binding affinities in the low nanomolar to picomolar range characteristic of monoclonal antibodies. The TCRm RL6A targets YLLPAIVHI peptide-HLA-A2 complexes, where the peptide is derived from the p68 RNA helicase protein. Previous work showed that this target is expressed by brain endothelial cells forming the blood-brain barrier (BBB).
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